OHSU Center for Spatial Systems Biomedicine

A systems biology approach to understanding and treating cancer

Tissues stained with either the targeted or untargeted probe alone demonstrate significant non-specific uptake. However, difference imaging using the DDSI method facilitates accurate assessment of biomarker tissue distribution. — Research work from Summer Gibbs, Ph.D., aids visualization of tumor margins during surgery

OCCSB involves top scientists from across many disciplines to develop better methods of detecting and treating cancers. A systems biology approach means a comprehensive look at all spatial scales, from the tiniest (molecular level) through the whole person, over time. Learn more about the OCSSB.

Events

11/19/2019Tuality Breast Cancer Conference

11/19/2019Knight School— Get SMMART: Challenges, opportunities, and new directions

11/22/20192019 Oregon Bioengineering Symposium

11/25/2019Unusual cytokinesis pathways in the early divergent trypanosomes - Ziyin Li, PhD (RJH 4340)

12/02/2019Combined Basic Science Research Seminar Series - Joe Gray, Ph.D., OHSU

VIEW CALENDAR

BME series

Download the BME series 2019–2020 schedule

News and announcements

How Precision Oncology Is Making Strides in the Fight Against Cancer (by Micron, Great Big Story, November 2019)
Cryo-EM technology helps elucidate KATP channel pharmacology, with implications for drug development (OHSU Now, November 1)
Dr. Joe Gray research on metastatic breast cancer funded by Komen (OHSU, September 17)
Cryo-Em: Powerful microscopes at OHSU allow scientists to push the bounds of biology (Portland Business Journal, Sept. 27) and OHSU receives $6M NIH grant to enhance high-resolution imaging (Sept. 13) and OHSU News
Xiaolin Nan, Ph.D. among eight promising cancer researchers named Lamfrom Laureates (OHSU, September 10)
Dr. Laura Heiser featured at September 17 OHSU Knight School: His, Hers, and Theirs: Re-thinking gender-specific cancers
Dr. Laura Heiser appointed Vice Chair of the Biomedical Engineering Department (OHSU OCSSB, July 22)
Summer Gibbs funded by Biomedical Innovation Program for “Near infrared nerve-specific probes enable improved surgical outcomes” (OHSU Research News, July 3)
BME graduate students in the Chang Lab Geoffrey Schau and Erik Burlingame competed in the InventOR Collegiate Challenge and won the $2,500 Impact Award for developing a new, less expensive way to detect cancer using artificial intelligence. Congratulations! (InventOR. July 1)
Jenny Eng, graduate student, Gibbs Lab, awarded the Exceptional Student Award for her presentation at the 34th Congress of the International Society for Advancement of Cytometry (June 26)
Jenny Eng, Ph.D. student, Gibbs Lab, wins Research Week poster presentation award for “Immune-tumor spatial architecture in breast cancer” (OHSU Research News, June 19)
Dr. Joe Gray testified before the U.S. Senate Committee on Finance in Washington D.C., at the invitation of Senator Ron Wyden, to address the importance of international collaboration in scientific research Read Dr. Gray’s article (OHSU News, June 17)
View testimony video and details (US Senate Committee on Finance, June 5)

View our News Archive on the Events page

Centers within the OCSSB

Multiple OCSSB projects have been designated national Research Centers by the National Cancer Institute (NCI) or the National Institute of Health:

The Measuring, Modeling, and Controlling Heterogeneity (M2CH) Center for Cancer System Biology, a U54 Reseach Center of the NCI Cancer Systems Biology Consortium.
Omic and Multidimensional Spatial Atlas of Metastatic Breast Cancer, or OMS Atlas, an NCI Human Tumor Atlas Network (HTAN) Research Center.
The Pacific Northwest Center for Cryo-EM (PNCC), a National CryoEM Center.
The Microenvironment Perturbagen (MEP) NIH Library of Integrated Network-based cellular signature Center, known as LINCS.
The Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) program is the flagship project of the Knight Cancer Institute’s Precision Oncology program.

Learn more about OCSSB research.

Faculty publications links

Joe Gray, Ph.D.
MyNCBI | Patents: USPTO

Laura Heiser, Ph.D.
MyNCBI

Young Hwan Chang, Ph.D.
Google Scholar

Kwang-Yung Chen (Koei Chin), M.D., Ph.D.
MyNCBI

Summer Gibbs, Ph.D.
MyNCBI

Sunjong Kwon, Ph.D.
MyNCBI

Xiaolin Nan, Ph.D.
MyNCBI
Google Scholar

Guillaume Thibault, Ph.D.
Thibault lab lists of publications

Multiscale Microscopy Core housed within OCSSB

The Multiscale Microscopy Core is a state-of-the-art electron microscopy research core established in 2013 by the OCSSB and FEI (now ThermoFisher Scientific). The MMC provides electron microscopy, related imaging services and technical support to both academic and industry professionals. Learn more about the MMC.