Eliot Spindel, MD, PhD is a professor in the Division of Neuroscience at the Oregon National Primate Research Center and holds joint appointments in the Knight Cancer Center, the Neuroscience Graduate Program and the Department of Behavioral Neuroscience and the Department of Cell, Developmental and Cancer Biology.
Fetal lung, infant lung, mature lung and lung cancer are all direct targets of nicotine because of the high expression of nicotinic receptors in normal, developing and diseased lung. A major focus of the Spindel laboratory is to understand the role of nicotinic receptors in normal lung development and develop therapeutic approaches to block the effects of prenatal nicotine exposure on lung development. This is being pursued in clinical studies in conjunction with the OHSU pediatrics and maternal-fetal medicine departments, in studies in monkeys and in transgenic mice. Key to understanding the effects of maternal smoking during pregnancy on lung development is understanding the balance between the nicotine addiction that drives continued smoking and the direct effects of nicotine on the developing lung. The epigenetic mechanisms underlying how maternal smoking during pregnancy causes life-long changes in offspring lung function are also being investigated. Because so many of the effects of smoking during pregnancy are mediated by nicotine, the Spindel laboratory is also interested in potential harms of e-cigarette use during pregnancy on offspring respiratory health.
The Spindel laboratory is also interested in clinical aspects of lung development in terms of better approaches to clinical care of premature infants. Towards that end, in collaboration with OHSU neonatologists and pediatricians we have developed NHP models of premature infant care and modes of CPAP delivery and are studying the potential beneficial effects of supplementary CPAP in moderatley premature infants.
In smokers, nicotine directly stimulates lung cancer growth by interacting with nicotinic receptors expressed on lung cancer cells. The ability of cholinergic signaling to stimulate lung cancer growth suggests multiple targets to develop new lung cancer therapies. Our lab is actively investigating the potential of nicotinic and muscarinic antagonists to block lung cancer growth as well as characterizing molecular mechanisms by which cholinergic signaling stimulates cancer growth and development. In particular the alpha 3, alpha 5 and alpha7 nicotinic receptors have been linked to lung cancer growth as has the M3 muscarinic receptor. Another area of investigation is the role of the nicotinic receptor modulatory proteins such as lynx1 and lynx2 in lung cancer growth.Read more
Areas of interest
- Basic Mechanisms of Lung Development
- Potential effects of smoking during pregnancy on lung development and therapeutic interventions
- Clinical approaches to lung development, prematurity and improved respiratory outcomes
- Epigenetic effects of in utero exposure to smoking
- Nicotine, nicotinic receptors and ly-6 proteins
- Nicotine and lung Cancer
- B.S., Massachusetts Institute of Technology 1974
- Ph.D., Massachusetts Institute of Technology 1980
- M.D., Harvard Medical School, Cambridge 1982
- 1980-1982 Postdoctoral Research Fellow (part-time), Laboratory of Neuroendocrine Regulation, Massachusetts Institute of Technology, Cambridge, MA
- 1982-1984 Postdoctoral Research Fellow, Molecular Endocrinology Lab, MA General Hospital, Boston, MA
Honors and awards
- 1974 Phi Beta Kappa, Massachusetts Institute of Technology,
- 1982 Graduation, cum laude, Harvard Medical School,
- 1982 Dr. Sirgay Sanger Award, Harvard Medical School,
- 1984 American Federation for Clinical Research Award to Trainees in Clinical Research,
Memberships and associations
- 1992-1995 Editorial Board, Molecular Endocrinology,
- 1992-1996 Regular member, Endocrine Study Section (NIH),
- 1997-2005 School of Medicine Research Committee, Oregon Health Sciences University,
- 2007 - 2014 ZRG1 RES-B NIH study section (Lung biology conflict study section)
- 2011 - 2017 Regular member, NIH Cancer Etiology (CE) Study Section
- American Society for Clinical Investigation
- Society for Neuroscience
- American Thoracic Society
McEvoy CT, Schilling D, Clay N, Jackson K, Go M, Spitale P, Bunten C, Leiva M, Gonzales D, Hollister-Smith J, Durand M, Frei B, Buist AS, Peters D, Morris CD, Spindel ER. Vitamin C Supplementation for Pregnant Smoking Women and Pulmonary Function in their Newborn Infants: A Randomized Clinical Trial. JAMA (2014), 311:2074-2082. PMCID: PMC4296045
Shorey-Kendrick LE, Ford MM, Allen DC, Kuryatov A, Lindstrom J, Wilhelm L, Grant KA and Spindel ER. Nicotinic receptors in non-human primates: analysis of genetic and functional conservation with humans. Neuropharmacology (2015) 96(Pt B):263-73. PMID: 25661700.
Spindel ER, McEvoy CT. The role of nicotine in the effects of maternal smoking during pregnancy on lung development and childhood respiratory disease: implications for dangers of e-cigarettes. Am J Respir Crit Care Med (2016),193:486-94. PM:26756937.