Photo of David B. Jacoby, M.D.

David B. Jacoby M.D.

    • Professor of Medicine School of Medicine
    • Chair, Department of Medicine Medicine School of Medicine
    • Laurence Selling Chair of Medicine
    • Director, MD/PhD Program
    • Neuroscience Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine
    • M.D./Ph.D. Program Committee School of Medicine

Dr. David Jacoby is professor of medicine, physiology and pharmacology and Chair of the Department of Internal Medicine at Oregon Health & Science University. He was born in New York, and is a graduate of Princeton University and New York Medical College. He was a resident and chief resident in internal medicine at Temple University Hospital and did his fellowship at the Cardiovascular Research Institute at the University of California, San Francisco. He was a member of the Division of Pulmonary and Critical Care Medicine at Johns Hopkins for 13 years, where he was research director for the division. He moved to OHSU to become division chief in 2003.

Education

  • B.A., Princeton, Princeton New Jersey 1976
  • M.D., New York Medical College, Valhalla New York 1980
  • Residency:

    • Internal medicine, Temple University Hospital, Philadelphia, Pennsylvania, 1981-1983
  • Fellowship:

    • Clinical pulmonary, University of California, San Francisco, 1984-1985
    • Pulmonary Research, Cardiovascular Research Institute, UCSF 1985 - 1987
  • Certifications:

    • Board Certified in Internal Medicine
    • Board Certified in Pulmonary Medicine
    • Board Certified in Critical Care Medicine

Publications

  • "Toll-like receptor-2/6 and toll-like receptor-9 agonists suppress viral replication but not airway hyperreactivity in guinea pigs" American Journal of Respiratory Cell and Molecular Biology June 2013
  • "Parainfluenza virus type 1 reduces the affinity of agonists for muscarinic receptors in guinea-pig lung and heart" European Journal of Pharmacology May 31 1990
  • "Viral infection increases contractile but not secretory responses to substance P in ferret trachea" Journal of Applied Physiology  1992
  • "Virus-induced asthma attacks" JAMA - Journal of the American Medical Association February 13 2002
  • "Physical activity and longevity of college alumni" New England Journal of Medicine  1986
  • "Eosinophil adhesion to cholinergic nerves via ICAM-1 and VCAM-1 and associated eosinophil degranulation" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  2002
  • "Toll-like receptor 7 rapidly relaxes human airways" American Journal of Respiratory and Critical Care Medicine September 15 2013
  • "Effects of neurokinin receptor antagonists in virus-infected airways" American Journal of Physiology - Renal Fluid and Electrolyte Physiology July 2000
  • "Protein kinase Cδ mediates lysophosphatidic acid-induced NF-κB activation and interleukin-8 secretion in human bronchial epithelial cells" Journal of Biological Chemistry September 24 2004
  • "Pathophysiology of airway viral infections" Pulmonary Pharmacology and Therapeutics December 2004
  • "Effect of viral infection on inhibitory prejunctional muscarinic receptors in guinea-pig airways" European Journal of Pharmacology July 4 1990
  • "Characterization of side population cells from human airway epithelium" Stem Cells October 2008
  • "Selective O-desulfation produces nonanticoagulant heparin that retains pharmacological activity in the lung" Journal of Pharmacology and Experimental Therapeutics July 1997
  • "Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase" Journal of Applied Physiology  1988
  • "General anesthesia in patients with viral respiratory infections" Anesthesiology  1991
  • "Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons" BMC Neuroscience September 11 2001
  • "Interleukin-1β mediates virus-induced M2 muscarinic receptor dysfunction and airway hyperreactivity" American Journal of Respiratory Cell and Molecular Biology October 1 2014
  • "Role of TNF-α in virus-induced airway hyperresponsiveness and neuronal M 2 muscarinic receptor dysfunction" British Journal of Pharmacology September 2011
  • "Interactions of eosinophils with nerves"   2014
  • "Pretreatment with antibody to eosinophil major basic protein prevents hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs" Journal of Clinical Investigation November 1 1997
  • "Function of pulmonary M2 muscarinic receptors in antigen-challenged guinea pigs is restored by heparin and poly-L-glutamate" Journal of Clinical Investigation December 1992
  • "Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs" Journal of Allergy and Clinical Immunology February 2011
  • "Abnormalities in neural control of smooth muscle in virus-infected airways" Trends in Pharmacological Sciences  1990
  • "Antigen sensitization influences organophosphorus pesticide-induced airway hyperreactivity" Environmental Health Perspectives March 2008
  • "The effects of epithelial cell supernatant on contractions of isolated canine tracheal smooth muscle" American Journal of Respiratory and Critical Care Medicine  1988
  • "Quantifying nerve architecture in murine and human airways using three-dimensional computational mapping" American Journal of Respiratory Cell and Molecular Biology January 2013
  • "Effects of tachykinin NK1 receptor antagonists on vagal hyperreactivity and neuronal M2 muscarinic receptor function in antigen challenged guinea-pigs" British Journal of Pharmacology  1998
  • "Muscarinic receptors and control of airway smooth muscle" American Journal of Respiratory and Critical Care Medicine  1998
  • "Structure of the human M2 muscarinic acetylcholine receptor gene and its promoter" Gene June 13 2001
  • "Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction" Journal of Clinical Investigation January 2006

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