Dr. Albert's research focuses on the treatment and prevention of ocular cancers; particularly the use of vitamin D analogues, resveratrol and its analogues, and anti-angiogenic peptides in the treatment and prevention of ocular cancer and in reversing angiogenesis in the wet form of macular degeneration. His preclinical data suggests that vitamin D analogues can prevent neovascularization in age-related macular degeneration, the leading cause of legal blindness among older Americans, as well as serve as an effective and relatively nontoxic treatment for retinoblastoma, melanoma, and neuroblastoma. His data further suggest that resveratrol inhibits tumor growth of human melanoma and neuroblastoma, and mediates apoptosis by directly targeting mitochondria. We have shown that calcium and calpain are key mediators of resveratrol-induced apoptosis in breast cancer. His findings also show that resveratrol can inhibit tumor growth and can induce apoptosis via the intrinsic mitochondrial pathway. By further increasing bioavailability of resveratrol, the potency can be increased, leading to tumor regression. The nontoxic nature of this therapy makes resveratrol an attractive candidate for the treatment of uveal melanoma. His latest research findings also suggest that Cisplatin given in combination with Calcitriol may be a more potent option in the treatment of high risk retinoblastoma than when given alone. Finally, he recently established a rat model for retinal and choroidal angiogenesis based on intense cyclic light exposure. Employing the rat model gives him the opportunity to utilize his experience and expertise in experimental eye pathology in general and, regarding angiogenesis and the action of vitamin D analogs in particular, for the study and treatment of age-related macular degeneration (AMD).
- B.S., Franklin and Marshall College, Lancaster Pennsylvania USA 1958
- M.D., University of Pennsylvania School of Medicine, Philadelphia Pennsylvania USA 1962
- M.S., University of Wisconsin - Madison, Madison USA 1997