Photo of Christina L. Lancioni, M.D.

Christina L. Lancioni M.D.

    • Associate Professor of Pediatrics, Division of Infectious Diseases School of Medicine
    • M.D./Ph.D. Program Committee School of Medicine

Dr. Lancioni’s research focuses on understanding how the human immune system responds to infection with mycobacterium tuberculosis. She is actively engaged in both laboratory and clinical research projects that aim to understand why young children develop severe forms of tuberculosis disease, and how to better diagnosis tuberculosis in children.

Education

  • M.D., University of Pennsylvania School of Medicine, Philadelphia Pennsylvania 2001
  • Residency:

    • Pediatrics, Children’s National Medical Center, 2004
  • Fellowship:

    • Pediatric infectious disease, Rainbow Babies and Children’s Hospital, 2009
  • Certifications:

    • American Board of Pediatrics, 2004

Memberships and associations

  • American Academy of Pediatrics

Publications

  • "CD8 + T cells provide an immunologic signature of tuberculosis in young children" American Journal of Respiratory and Critical Care Medicine January 15 2012
  • "Polymorphisms in TICAM2 and IL1B are associated with TB" Genes and Immunity March 1 2015
  • "Rv2468c, a novel Mycobacterium tuberculosis protein that costimulates human CD4 + T cells through VLA-5" Journal of Leukocyte Biology February 2012
  • "Recurrent infection with epidemic Clostridium difficile in a peripartum woman whose infant was asymptomatically colonized with the same strain" Clinical Infectious Diseases March 15 2008
  • "Effects of antiretroviral therapy on immune function of HIV-infected adults with pulmonary tuberculosis and CD4+ >350 cells/mm3 " Journal of Infectious Diseases April 1 2011
  • "Tuberculin skin test reversion following isoniazid preventive therapy reflects diversity of immune response to primary Mycobacterium tuberculosis infection" PLoS One May 5 2014
  • "Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4+ T cell activation via toll-like receptors 1 and 2" Infection and Immunity February 2011
  • "Contact investigation for active tuberculosis among child contacts in Uganda" Clinical Infectious Diseases December 2013
  • "Pulmonary tuberculosis presenting as fever without source in a pediatric patient with acute lymphoblastic leukemia" Pediatric Blood and Cancer December 15 2009
  • "Evolution of human immunodeficiency virus type 1 in relation to disease progression in children" Journal of Human Virology March 1998
  • "Activation requirements and responses to TLR ligands in human CD4+ T cells" Journal of Immunological Methods May 15 2009
  • "TLR2 engagement on CD4+ T cells enhances effector functions and protective responses to Mycobacterium tuberculosis" European Journal of Immunology  2014
  • "Tuberculosis treatment in HIV infected ugandans with CD4 counts >350 cells/mm3 reduces immune activation with no effect on HIV load or CD4 count" PLoS One February 22 2010
  • "Prenatal care and HIV infection" AIDS Patient Care and STDs  1999
  • "Direct TLR-2 costimulation unmasks the proinflammatory potential of neonatal CD4+ T cells" Journal of Immunology July 1 2016
  • "Immunobiology of Pediatric Tuberculosis" Journal of Pediatric Infectious Diseases April 27 2017
  • "The effect of interrupted anti-retroviral treatment on the reconstitution of memory and naive T cells during tuberculosis treatment in HIV patients with active pulmonary tuberculosis" African Health Sciences January 1 2017
  • "CD4+ T cell activation during the newborn period" Critical Reviews in Immunology January 1 2018
  • "Resistance and Susceptibility to Mycobacterium tuberculosis Infection and Disease in Tuberculosis Households in Kampala, Uganda" American Journal of Epidemiology July 1 2018
  • "Notes from the Field" Morbidity and Mortality Weekly Report March 8 2019
  • "Childhood Acute Illness and Nutrition (CHAIN) Network" BMJ Open May 1 2019
  • "Recognition of CD8+ T-cell epitopes to identify adults with pulmonary tuberculosis" European Respiratory Journal May 1 2019
  • "Undernutrition, Host Immunity and Vulnerability to Infection Among Young Children" Pediatric Infectious Disease Journal August 1 2019

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