Hot Topics

 "Hot Topics" highlight ORPRN projects that are creating conversation and having an impact statewide.

Rave project team at kick-off

RAVE project aims to drive vaccination rates in rural Oregon and across the country

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Did you know that we can prevent cancer of the cervix, throat, and elsewhere through HPV vaccination? The vaccine is safe and effective for both males and females, ages 9-26 years.  The Rural Adolescent Vaccine Enterprise, also known as RAVE, is a research study designed to understand why vaccination rates are low in rural settings and identify new ways to improve them.

  • Principal Investigators: LJ Fagnan, M.D.; Patty Carney, M.D.
  • Institution: Oregon Rural Practice-based Research Network, OHSU
  • Project Dates: July 1, 2018 – June 30, 2023

Although the HPV vaccine has been available for over a decade and has demonstrated effectiveness in preventing precancerous changes in the cervix, anus, and oral cavity, we fall far short of achieving the Healthy People 2020 goal of 80% completion of the vaccine series by ages 13-15 years. 

The national completion rate is less than 50% of the CDC Benchmark;  in rural Oregon, the county-level  HPV completion rate is 27.8%.  To improve HPV vaccination rates, it is necessary to change practice behavior and knowledge in Oregon communities about the vaccine .

 In partnership with the State of Oregon Immunization Program and 40 participating primary care practices in rural Oregon, the RAVE research team at the Oregon Rural Practice-based Research Network (ORPRN) will increase the capacity of practices to sustain a quality improvement (QI) structure and processes that lead to improved immunization rates.

 ORPRN Practice Enhancement and Research Coordinators will act as facilitators, and will provide boots-on-the-ground support for the practice QI team.  The findings from RAVE will improve HPV immunization rates across rural Oregon and will be shared across rural America.

On March 14, 2019, a protocol paper outlining the study’s stepped-wedge cluster randomized design was published in the journal Implementation Science.

For more information, contact RAVE Project Manager Caitlin Dickinson at

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