Research Focus: Dr. Pike's research is focused on studying the pathophysiology of brain diseases (malignant glioma, stroke) using MRI/MRS in tandem with other approaches. His lab employs dynamic contrast MRI approaches to investigate anti-angiogenic/anti-tumor treatment strategies employing mouse models of malignant glioma. His laboratory is currently developing novel combinational treatment strategies for malignant glioma which exploit autophagic cell death. These are implemented in combination with immunohistological analyses and in vitro assessments of underlying mechanisms. Dr Pike's goal is to develop effective molecularly- targeted combination treatment strategies which will provide hope for patient with malignant glioma. His group is also investigating stroke neuroprotection strategies, and employing MR based molecular imaging approaches to investigate stroke related inflammation.
Biography: Dr. Pike received his undergraduate degree from Williams College in Williamstown, MA in 1978 and his doctoral degree from SUNY in the Department of Chemistry in 1985. He was an NIH Postdoctoral Fellow at The Johns Hopkins University School of Medicine, Division of Cardiology in Baltimore, MD (1985-88), Dr. Pike was a faculty member at the Department of Medicine, Division of Cardiovascular Disease and Department of Cell Biology at the University of Alabama at Birmingham from 1988 to 2008. He joined the AIRC in 2007 as a Visiting Scholar and 2008 as an Associate Scientist and full member of the OHSU Knight Cancer Institute.
1. M.M. Pike, C. N. Stoops, C. P. Langford, , N. Shastry Akella, L.B. Nabors, G Y Gillespie; High-resolution, longitudinal assessment of flow and permeability in mouse glioma vasculature: sequential small molecule and SPIO dynamic contrast agent MRI; Magn Res Med; 61(3):615-25 (2009)
2. Lobo M.R., Green S.C, Schabel M.C., Gillespie G.Y., Woltjer R.L., M.M. Pike; Quinacrine Synergistically Enhances the Anti-vascular and Anti-tumor Efficacy of Cediranib in Intracranial Mouse Glioma; Neuro-Oncology Neuro-Oncology 2013 15(12):1673–1683
3. Lobo M.R., Wang X.,., Gillespie G.Y., Woltjer R.L., M.M. Pike; Combined Efficacy of Cediranib and Quinacrine in Glioma is Enhanced by Hypoxia and Causally Linked to Autophagic Vacuole Accumulation, PLoS One, 2014. 9(12): p. e114110.