OHSU

Martin Pike

Martin PikeResearch Focus: Dr. Pike's current research is focused on studying the pathophysiology of brain diseases (stroke, malignant glioma, alzheimers) using MRI/MRS in tandem with other approaches.  His lab employs dynamic contrast MRI approaches to investigate anti-angiogenic/anti-tumor treatment strategies employing mouse models of malignant glioma. His group is also investigating blood brain barrier disruption in stroke and stroke neuroprotection strategies.  MR based molecular imaging approaches are also being employed to investigate stroke related inflammation.

Biography: Dr. Pike received his undergraduate degree from Williams College in Williamstown, MA in 1978 and his doctoral degree from SUNY in the Department of Chemistry in 1985. He was an NIH Postdoctoral Fellow at The Johns Hopkins University School of Medicine, Division of Cardiology in Baltimore, MD (1985-88),  Dr. Pike was a faculty member at the Department of Medicine, Division of Cardiovascular Disease and Department of Cell Biology at the University of Alabama at Birmingham from 1988 to 2008.  He joined the AIRC in 2007 as a Visiting Scholar and 2008 as an Associate Scientist and full member of the OHSU Knight Cancer Institute.

Key Publications:

Takayama E, Guo L-L, Digerness SB, Pike MM.  Early reperfusion levels of Na+ and Ca2+ are strongly associated with postischemic functional recovery but are disassociated from KATP channel-induced cardioprotection.  J Mol Cell Cardiol 37(2):483-96, 2004.


M.M. Pike, C. N. Stoops, C. P. Langford, N. Shastry Akella, L.B. Nabors, G Y Gillespie; High-resolution, longitudinal assessment of flow and permeability in mouse glioma vasculature: sequential small molecule and SPIO dynamic contrast agent MRI; Magn Res Med; 61(3):615-25 (2009) 

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