OHSU

Thomas S. Scanlan, Ph.D.

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Background

The current research in the Scanlan Lab is centered broadly in the area of hormone action, with an emphasis on the classic endocrine modulators belonging to the steroid/thyroid family. These hormones coordinate a variety of important physiologic functions in development and homeostasis, and they mediate the regulation with exquisite selectivity. One of the Lab's primary activities is to develop an understanding of the molecular basis of the tissue-selectivity of these hormones using a multidisciplinary approach that involves synthetic chemistry, biochemistry, cell biology, and ultimately


Summary of Current Research


Selected Publications

"Effects of acute microinjections of the thyroid hormone derivative 3-iodothyronamine to the preoptic region of adult male rats on sleep, thermoregulation and motor activity," Hormones and Behavior (Vol: 64, Issue: 1, Page 81-88) - 2013

"Erratum: The Synthesis of 13C9-15N-Labeled 3,5-Diiodothyronine and Thyroxine(Synthetic Communications (2013) 43:10 (1439-1446))," Synthetic Communications (Vol: 43, Issue: 13, Page 1865-) - 2013

"NMR-based metabolomics and breath studies show lipid and protein catabolism during low dose chronic T1AM treatment," Obesity (Vol: 21, Issue: 12, Page 2538-2544) - 2013

"The synthesis of 13C9-15N-labeled 3,5-diiodothyronine and thyroxine," Synthetic Communications (Vol: 43, Issue: 10, Page 1439-1446) - 2013

"ApoB-100-containing lipoproteins are major carriers of 3-iodothyronamine in circulation," Journal of Biological Chemistry (Vol: 287, Issue: 3, Page 1790-1800) - 2012

 

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Contact

  Email Thomas Scanlan

503 494-9292

Memberships & Associations

Professor of Physiology and Pharmacology
Director, Program in Chemical Biology