Pediatric research laboratories are located in the Child Development & Rehabilitation Center (CDRC) and the new Biomedical Research Building (BRB).
Laboratory research activity is supported by a departmental team headed by Dr. Roullet, that reports to the Vice-Chair for Research: Qianyue Yang (general lab staff support & maintenance manager),Sylvia Hathaway (administrative support), and Douglas Church (financial analyst).
We encourage everyone interested in research to explore this page. This is a unique opportunity to learn about the exciting research that takes place in our labs and to participate in the discoveries that will shape pediatric care in the future.
Jean-Baptiste Roullet, Ph.D., Research Associate Professor , is the Manager of the Pediatrics Research Laboratories. He earned degrees in Pharmacy and Laboratory Medicine in Paris, France and practiced Clinical Chemistry for several years before joining the OHSU faculty in 1989.
Dr. Roullet has published several high-impact publications in the field of lipid metabolism and function, vascular physiology and pharmacology. He is the lead author in the report that first characterized the regulatory role of endogenous alcohols in mammalian neuronal signaling, and has discovered a highly promising link between these alcohols and the Sjogren-Larsson Syndrome, a rare inherited metabolic disease affecting children. His current research interests include rare diseases caused by disorders of the sterol and isoprenoid pathway, autism and stem cell research.
Stephen Back Lab
The Back Lab focuses on the development of novel strategies to promote regeneration and repair of injury to the developing brain.
Paul Barnes Lab
The Barnes Lab focuses on the fundamental cellular mechanisms that control the development of the cerebral cortex prior to and following birth.
Bill Chang Lab
The Chang Lab focuses on developing novel targets for therapies in pediatric leukemias.
Markus Grompe Lab
The Grompe Lab focuses on development of novel treatments for gene transfer and cell therapy; specifically looking at metabolic liver diseases and the DNA repair disease Fanconi Anemia.
Charles Keller Lab
The Keller Lab focuses on the driving mechanisms and therapeutic targets in the childhood muscle cancers, alveolar rhabdomyosarcomaand embryonal rhabdomyosarcoma, and the childhood brain tumor, medulloblastoma.
Peter Kurre Lab
The Kurre Lab focuses on developing novel strategies for the safe and effective modification of hematopoietic stem cells to treat benign and malignant disease.
Christina Lancioni Lab
The Lancioni laboratory studies infant immune responses to the pathogen the causes Tuberculosis disease, Mycobacterium tuberculosis (Mtb).
Jae Lee Lab
The Jae Lee Lab's goal is to understand the transcriptional regulatory network in metabolism.
Soo Lee Lab
The Soo Lee Lab's goal is to develop a comprehensive map of the complex gene regulatory networks that direct cell-fate specification and assembly of neuro-circuits.
Deborah Lewinsohn Lab
The Lewinsohn Lab focuses on the immunology of childhood tuberculosis.
Daniel Marks Lab
The Marks' Lab focuses on the mechanisms whereby circulating cytokines activate the central melanocortin system.
Dawn Nolt Lab
The Nolt Lab focus is to investigate the interaction of Mtb and CD8+ T cell immunity. The studies will advance knowledge in key areas: 1) Mtb interactions in host cells and 2) modulation of immune function during Mtb infection.
Mike Powers Lab
The Powers' lab uses a mouse model of retinopathy of prematurity (ROP) to investigate the balance between angiogenic cytokines and pro-apoptotic factors in retinal neovascularization.
Ron Rosenfeld Lab
The Rosenfeld Lab has a long-standing interest in growth failure resulting from defects in IGF-I production and action.
Robert Steiner Lab
The Steiner Lab studies rare genetic disorders in which the body cannot properly synthesize or process cholesterol.
Zili Zhang Lab
The Zhang Lab focuses on studying our immune system to help understand the mechanisms of many diseases and to develop more effective treatment strategies.