Carsten Schultz, Ph.D.
Primary AffiliationProfessor & Chair Physiology and Pharmacology Department
SOM - Physiology and Pharmacology Department
Background & Education
Ph.D., Chemistry, Bremen University, Germany
1990-93 Postdoctoral, Pharmacology, University of California San Diego
For two decades, my laboratory has been developing tools to help understanding the cell biology of signaling networks. Our techniques permit the visualization as well as the non-invasive manipulation of intact cells. Since several years, one focus of our work is to understand how growth factor signaling, for instance by epidermal growth factor(EGF), is partially mediated and ultimately terminated by receptor internalization. In 2014, we published the finding that elevated levels of the signaling lipid phosphatidylinositol 3,4,5-trisphosphate (PIP3) comprised a sufficient signal to induce EGF receptor (EGFR) internalization. Interestingly, this internalization in the absence of tyrosine phosphorylation and ubiquitination leads to full recycling of the receptor. We speculate that such a scenario is relevant in cells that require ongoing growth factor signaling such as the growth cone of an axon but also late stage cancer cells where mutations in a PIP3-modulating enzyme such as PTEN lead to increased signaling and proliferation.
Our move to Portland brings us close to a vibrant scientific community interested in cancer research. Therefore, we would like to continue our studies on EGFR internalization and find out what lipids and proteins are involved in mediating the PIP3 signal to the endocytic machinery and what molecular epitope of the EGFR is recognized to make EGFR a cargo.
Carsten Schultz, Ph.D.
3181 SW Sam Jackson Park Rd.
Portland, OR 97239-3098
ph: (503) 418-2096
fax: (503) 494-4352
J., Broichhagen, J., Yushchenko, D., Trauner, D., Schultz, C.,
Hodson, D. Optical tools for understanding the complexity of beta cell
signaling and insulin release. Nat. Rev.
Dittrich, A. S.,
Kuehbandner, I., Gehrig, S., Rickert-Zacharias, V., Twigg, M., Wege, S.,
Taggert, C., Herth, F., Schultz, C., Mall, M. Elastase activity on sputum
neutrophils correlates with severity of lung disease in cystic fibrosis. Eur. Resp. J. 29, pii 1701910 (2018).
Kath, C., Mueller, R., Schultz, C., Haucke, V., Eickholt, B., Schmoranzer, J. PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules. PLoS One 13, e0193257 (2018).
Hauke, S., Keutler, K.,
Yushchenko, D., Schultz, C. Endogenous Fatty Acids are Essential Autocrine
Signaling Factors of Pancreatic β-Cells
and Insulin Secretion. Diabetes 67, (2018).
Dziuba, D., Stein, F., Schultz, C. A bifunctional noncanonical amino acid:
synthesis, expression and residue-specific proteome-wide incorporation. Biochemistry (2018).
Kirby, I. T., Kojic, A., Arnold, M. R., Thorsell, A.-G., Karlberg, T., Vermehren-Schmaedick, A., Sreenivasan, R., Schultz, C., Schüler, H., Cohen M. S. A potent and selective PARP11 inhibitor suggests coupling between cellular localization and catalytic activity. Cell Chem. Biol. (2018).
Yu, X., Akbarzadeh, R., Pieper, M., Scholzen, T.,
Gehrig, S., Schultz, C., Zillikens, D., König, P., Petersen, F. Neutrophil
adhesion is a prerequisite for antibody-mediated proteolytic tissue damage in
experimental models of epidermolysis
bullosa acquisita. J. Invest. Dermatol.
Frank,, J. A., Yushchenko, D. A., Fine, N. H. F., Duca, M.,
Citir, M., Broichhagen, J., Hodson, D. J., Schultz, C., Trauner, D. Optical
control of GPR40 signalling in pancreatic ß-cells. Chem. Sci. 8, 7604-7610 (2017).
Müksch, F., Laketa, V., Müller, B., Schultz, C., Kräusslich, H.-G. Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring. eLife 6, e25287 (2017).
Zuidscherwoude, M., Dunlock, V.-M. E., van den Bogaart, G., van Deventer, S.J., van der Schaaf, A., van Oostrum, J., Goedhart, J., In 't Hout, J., Hämmerling, G. J., Tanaka, S., Nadler, A., Schultz, C., Wright, M. D., Adjobo-Hermans, M. J. W., van Spriel, A. B. Tetraspanin microdomains control localized protein kinase C signaling in B cells. Sci. Signal. 10, eaag2755 (2017).
Walter*, A., Mueller, R., Wierda, K. D. B., Tawfik, B., Pinheiro, P. S., Nadler, A., Ziomkiewicz, I., Kruse, M., Reither, G., Rettig, J., Haucke, V., Hille, B., Schultz*, C., Soerensen*, J. Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis, eLife 6, e30203 (2017). DOI: https://doi.org/10.7554/eLife.30203Bogdanova, Y. A., Schultz, C., Belousov, V. V. Local Generation and Imaging of Hydrogen Peroxide in Living Cells. Curr. Protocols Chem. Biol. 9, 117-127 (2017).
Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S,
Belaaouaj A, Dalpke AH, Schultz C, Mall MA.Lack of neutrophil elastase reduces
inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in
mice with cystic fibrosis-like lung disease. Am J Respir Crit Care Med. 2014 May
1;189(9):1082-92. PMID: 24678594