Carsten Schultz, Ph.D.
Primary AffiliationProfessor & Chair Physiology and Pharmacology Department
SOM-Physiology and Pharmacology Department
Background & Education
Ph.D., Chemistry, Bremen University, Germany
1990-93 Postdoctoral, Pharmacology, University of California San Diego
For two decades, my laboratory has been developing tools to help understanding the cell biology of signaling networks. Our techniques permit the visualization as well as the non-invasive manipulation of intact cells. Since several years, one focus of our work is to understand how growth factor signaling, for instance by epidermal growth factor(EGF), is partially mediated and ultimately terminated by receptor internalization. In 2014, we published the finding that elevated levels of the signaling lipid phosphatidylinositol 3,4,5-trisphosphate (PIP3) comprised a sufficient signal to induce EGF receptor (EGFR) internalization. Interestingly, this internalization in the absence of tyrosine phosphorylation and ubiquitination leads to full recycling of the receptor. We speculate that such a scenario is relevant in cells that require ongoing growth factor signaling such as the growth cone of an axon but also late stage cancer cells where mutations in a PIP3-modulating enzyme such as PTEN lead to increased signaling and proliferation.
Our move to Portland brings us close to a vibrant scientific community interested in cancer research. Therefore, we would like to continue our studies on EGFR internalization and find out what lipids and proteins are involved in mediating the PIP3 signal to the endocytic machinery and what molecular epitope of the EGFR is recognized to make EGFR a cargo.
Carsten Schultz, Ph.D.
3181 SW Sam Jackson Park Rd.
Portland, OR 97239-3098
ph: (503) 418-2096
fax: (503) 494-4352
Yu, X., Akbarzadeh, R., Pieper, M., Scholzen, T., Gehrig, S., Schultz, C., Zillikens, D., König, P., Petersen, F. Neutrophil adhesion is a prerequisite for antibody-mediated proteolytic tissue damage in experimental models of epidermolysis bullosa acquisita. J. Invest. Dermatol. (2018). doi: 10.1016/j.jid.2018.03.1499Marat, A., Wallroth, A., Lo, W.-T., Mueller, R., Norata, G. D., Falasca, M., Schultz, C., Haucke, V. "Phosphatidylinositol 3,4-bisphosphate represses nutrient signaling by mTORC1" Science 356, 968-972 (2017).
Frank,, J. A., Yushchenko, D. A., Fine, N. H. F., Duca, M., Citir, M., Broichhagen, J., Hodson, D. J., Schultz, C., Trauner, D. Optical control of GPR40 signalling in pancreatic ß-cells. Chem. Sci. 8, 7604-7610 (2017). doi: 10.1039/c7sc01475a
Müksch, F., Laketa, V., Müller, B., Schultz, C., Kräusslich, H.-G. Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring. eLife 6, e25287 (2017).
Zuidscherwoude, M., Dunlock, V.-M. E., van den Bogaart, G., van Deventer, S.J., van der Schaaf, A., van Oostrum, J., Goedhart, J., In 't Hout, J., Hämmerling, G. J., Tanaka, S., Nadler, A., Schultz, C., Wright, M. D., Adjobo-Hermans, M. J. W., van Spriel, A. B. Tetraspanin microdomains control localized protein kinase C signaling in B cells. Sci. Signal. 10, eaag2755 (2017).
Walter*, A., Mueller, R., Wierda, K. D. B., Tawfik, B., Pinheiro, P. S., Nadler, A., Ziomkiewicz, I., Kruse, M., Reither, G., Rettig, J., Haucke, V., Hille, B., Schultz*, C., Soerensen*, J. Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis, eLife 6, e30203 (2017). DOI: https://doi.org/10.7554/eLife.30203
Dittrich, A. S., Kuehbandner, I., Gehrig, S., Rickert-Zacharias, V., Twigg, M., Wege, S., Taggert, C., Herth, F., Schultz, C., Mall, M. Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis. Eur. Resp. J. 29, pii 1701910 (2018). doi: 10.1183/13993003.01910-2017
Kath, C., Mueller, R., Schultz, C., Haucke, V., Eickholt, B., Schmoranzer, J. PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules. PLoS One 13, e0193257 (2018). doi: 10.1371/journal.pone.0193257.
Hauke, S., Keutler, K., Yushchenko, D., Schultz, C. Endogenous Fatty Acids are Essential Autocrine Signaling Factors of Pancreatic β-Cells and Insulin Secretion. Diabetes 67, (2018). doi.org/10.2337/db17-1215
Hoffmann, J.-E., Dziuba, D., Stein, F., Schultz, C. A bifunctional noncanonical amino acid: synthesis, expression and residue-specific proteome-wide incorporation. Biochemistry (2018). In press
Bogdanova, Y. A., Schultz, C., Belousov, V. V. Local Generation and Imaging of Hydrogen Peroxide in Living Cells. Curr. Protocols Chem. Biol. 9, 117-127 (2017).
Frank, J., Broichhagen, J., Yushchenko, D., Trauner, D., Schultz, C., Hodson, D. Optical tools for understanding the complexity of beta cell signaling and insulin release. Nat. Rev. Endocrinol. (2018) accepted
Laguerre A, Schultz C. Novel lipid tools and probes for biological investigations. Curr Opin Cell Biol. 2018 Aug;53:97-104. doi: 10.1016/j.ceb.2018.06.013. Epub 2018 Jul 14. Review. PubMed PMID: 30015291
I. T., Kojic, A., Arnold, M. R., Thorsell, A.-G., Karlberg, T.,
Vermehren-Schmaedick, A., Sreenivasan, R., Schultz, C., Schüler, H., Cohen M.
S. A potent and selective PARP11 inhibitor suggests
coupling between cellular localization and catalytic activity. Cell Chem. Biol. (2018). accepted