The Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN)

Diagram of all OHSU SIREN sites

What is SIREN?

The goal of the SIREN Network is to improve the outcomes of patients with neurologic, cardiac, respiratory and hematologic emergencies by identifying effective treatments given in the earliest stages of care. SIREN is a cooperative and highly integrated clinical trials network that will build upon guiding design principles and organizational values essential for success. These include focus on:

  • early treatment
  • meaningful outcomes for patients
  • efficiency
  • collaboration
  • transforming the clinical trials enterprise


As a 'hub' site within the SIREN network, OHSU has created a network of partner institutions who will collaborate and participate with OHSU in SIREN trials.  Our partner institutions are nationwide and represent a diverse group of patients, populations, and care teams.  

Recent News & Events


HOBIT - Hyperbaric Oxygen Brain Injury Treatment Trial

The OHSU Network will have 3 institutions participating in HOBIT.  Duke is currently enrolling subjects, OSU, and UAB are both expecting to start enrolling subjects in the near future. 

BOOST-3 - Brain Oxygen Optimization in Severe TBI Phase-3

This study is anticipated to start in 2020.