Photo of Young Hwan Chang, Ph.D.

Young Hwan Chang Ph.D.

    • Assistant Professor of Computational Biology Program School of Medicine
    • Assistant Professor of Biomedical Engineering School of Medicine
    • Biomedical Engineering Graduate Program School of Medicine
    • OHSU Center for Spatial Systems Biomedicine School of Medicine

Our current research area aims to develop a general framework for quantifying multi-scaling imaging. Special emphasis will be on developing a novel image analysis tool to understand spatial distribution of cancer cells and their interactions. We will use and adapt state-of-art machine learning/deep learning techniques for exploratory data analysis by rigorous data integration. 

Areas of interest

  • Quantitative image analysis, Data-driven system identification, Control theory, Machine learning


  • B.S., Aerospace Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea 2002
  • M.S., Aerospace Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea 2004
  • Ph.D., Mechanical Engineering (Control, Systems Theory), UC Berkeley, Berkeley California United States 2013

Honors and awards

  • CRUK-OHSU Spark Award (2018)

Memberships and associations

  • Editorial board for Computerized Medical Imaging and Graphics (2019-present)


  • "Optimization-based inference for temporally evolving networks with applications in biology" Journal of Computational Biology December 1 2012
  • "Heterogeneity in cancer dynamics"  July 28 2015
  • "Optimization-based inference for temporally evolving Boolean networks with applications in biology"   2011
  • "Disentangling multidimensional spatio-temporal data into their common and aberrant responses" PLoS One April 22 2015
  • "Walking pattern generation for humanoid robots with LQR and feedforward control method"   2008
  • "Accelerating submovement decomposition with search-space reduction heuristics" IEEE Transactions on Biomedical Engineering October 1 2015
  • "Low-rank representation of neural activity and detection of submovements"   2013
  • "Optical phase estimation for a patch-type extrinsic Fabry-Perot interferometer sensor system and its application to flutter suppression" Smart Materials and Structures August 1 2005
  • "Modeling response of biological signal pathways using a hybrid boolean framework"   2012
  • "A design of neural decoder by reducing discrepancy between Manual Control (MC) and Brain Control (BC)"  July 22 2014
  • "Online phase tracking of interferometric optical fiber sensors for vibration control" Journal of Intelligent Material Systems and Structures April 2007
  • "Balance control in whole body coordination framework for biped humanoid robot MAHRU-R"   2008
  • "Data-driven graph reconstruction using compressive sensing"   2012
  • "Inference of temporally evolving network dynamics with applications in biological systems"   2011
  • "Biologically-inspired coordination of multiple UAVs using sliding mode control"   2011
  • "A patch-type smart self-sensing actuator" Smart Materials and Structures June 1 2006
  • "Vibration suppression and balance control for biped humanoid walking"   2008
  • "Development of a foot mechanism for landing experiment"   2008
  • "Reconstruction of gene regulatory networks with hidden nodes"  July 22 2014
  • "An omni-directional walking pattern generation method for humanoid robots with quartic polynomials"   2007
  • "Retrieving common dynamics of gene regulatory networks under various perturbations"  February 8 2016
  • "Sparse network identifiability via Compressed Sensing" Automatica  2016
  • "Exact reconstruction of gene regulatory networks using compressive sensing" BMC Bioinformatics  2014
  • "Iterative function separation for gene regulatory function identification"  February 8 2016
  • "Reconstruction of Gene Regulatory Networks Based on Repairing Sparse Low-Rank Matrices" IEEE/ACM Transactions on Computational Biology and Bioinformatics July 1 2016
  • "Design of a neural decoder by sensory prediction and error correction" Indian Journal of Rheumatology  2014
  • "Primer for image informatics in personalized medicine" Indian Journal of Rheumatology  2016
  • "Quantitative analysis of histological tissue image based on cytological profiles and spatial statistics"  October 13 2016
  • "Secure estimation for unmanned aerial vehicles against adversarial cyber attacks"   2016
  • "Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis" Cell Reports April 4 2017

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