Victoria HJ Roberts, Ph.D.

  • Associate Professor, Oregon National Primate Research Center
  • Obstetrics and Gynecology, School of Medicine

Biography

Victoria Roberts, Ph.D., is an Associate Professor in the Division of Developmental and Reproductive Sciences at the Oregon National Primate Research Center. Her overall research objective is to understand the developing placenta. Within this area of research, Dr. Roberts utilizes both in vivo and in vitro methods to investigate placental function.

Through the use of advanced imaging modalities such as ultrasound and magnetic resonance imaging (MRI), Dr. Roberts and colleagues have made in vivo assessments of placental hemodynamics in several nonhuman primate models of pregnancy complications, and in studies conducted in pregnant women. Gaining a better understanding of the placenta in utero may assist in the clinical management of pregnancies that are found to be at-risk for placental insufficiency.

Furthermore, Dr. Roberts performs in vitro functional experiments in placental tissue post-delivery. When combined with structural assessments of the tissue, these in vitro studies provide insight as to the mechanisms of action that regulate function, and reveal the developmental changes that occur in adverse in utero conditions that underlie pregnancy complications.

Education and training

    • B.S., 1999, University of Reading
    • Ph.D., 2004, University of Manchester
  • Fellowship

    • Postdoctoral Fellow, University of Cincinnati, Cincinnati, OH, 2008

Memberships and associations:

  • Member, International Federation of Placenta Association, 2001-present
  • Member, Developmental Origins of Adult Disease Society, 2006-present
  • Member, Society for Reproductive Investigation, 2006-present

Areas of interest

  • Placental physiology
  • Developmental biology
  • In vitro model systems
  • In vivo imaging

Honors and awards

  • 2016, SMFM Research Excellence Award, Society for Maternal Fetal Medicine, Atlanta
  • 2017, SMFM Research Excellence Award, Society for Maternal Fetal Medicine, Las Vegas
  • 2018, American Journal of Obstetrics & Gynecology, Research Excellence Award, Highly cited publication
  • 2019, American Journal of Obstetrics & Gynecology, Research Excellence Award, Highly cited publication

Publications

Selected publications

  • RC Wilson, JO Lo, G Romero Jimenez, JR Lindner, OD Slayden, VHJ Roberts (2023) Utilizing contrast-enhanced ultrasonography with phosphatidylserine microbubbles to detect placental inflammation in rhesus macaques. Molecules. 28(7): 2894.
  • VHJ Roberts, MC Schabel, ER Boniface, RJ D’Mello, TK Morgan, JJD Terrobias, JA Graham, LM Borgelt, KA Grant, EL Sullivan, JO Lo. (2022) Chronic Prenatal Delta-9-tetrahydrocannabinol Exposure Adversely Impacts Placental Function and Development in a Rhesus Macaque Model. Scientific Reports. Nov 24;12(1):20260.
  • Roberts VH, Gaffney JE, Lewandowski KS, Schabel MC, Morgan TK, Frias AE. A standardized method for collection of human placenta samples in the age of functional magnetic resonance imaging. Biotechniques. 2019 Aug;67(2):45-49. doi: 10.2144/btn-2019-0029. Epub 2019 Jun 11. PMID: 31184493; PMCID: PMC7027198. 
  • MC Schabel#, VHJ Roberts#, KJ Gibbins, M Rincon, JE Gaffney, AD Streblow, AM Wright, JO Lo, B Park, CD Kroenke, K Szczotka, NR Blue, JM Page, K Harvey, MW Varner, RM Silver, AE Frias (2022) Assessing placental function across gestation: a multi-institutional study of BOLD-MRI for the prediction of adverse pregnancy outcomes. PLOS One. Jul 19;17(7):e0270360. PMID: 35853003 #Joint first author
  • JL Rosenkrantz, JE Gaffney, VHJ Roberts, L Carbone and SL Chavez (2021) Transcriptomic comparison of primate placentas reveals the utility of novel rhesus macaque trophoblast cell lines for investigating human placentation. Biology of Reproduction. Jun 21;19(1):127. PMID: 34154587; PMCID: PMC8218487.
  • VHJ Roberts, JA Gaffney, KS Lewandowski, MC Schabel, TK Morgan, AE Frias (2019) A standardized method for collection of human placenta samples in the age of functional magnetic resonance imaging. BioTechniques Aug;67(2):45-49. PMID: 31184493; PMCID: PMC7027198.
  • JA Sargent, VHJ Roberts, JA Gaffney, AE Frias (2019) Clarification and confocal imaging of the nonhuman primate placenta micro-anatomy. BioTechniques Feb;66(2):79-84. PMID: 30370778; PMCID: PMC6521839.
  • AJ Hirsch#, VHJ Roberts#, PL Grigsby, N Haese, MC Schabel, X Wang, JO Lo, Z Liu, CD. Kroenke, JL Smith, M Kelleher, R Broeckel, CN Kreklywich, CJ Parkins, M Denton, P Smith, V DeFilippis, W Messer, JA Nelson, JD Hennebold, M Grafe, L Colgin, A Lewis, et al, (2018) Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology. Nature Communications Jan 17;9(1):263 PMID: 29343712; PMCID: PMC5772047. #Joint first author
  • VHJ Roberts, TK Morgan, MD, P Bednarek, M Morita, GJ Burton, JO Lo and AE Frias (2017) Early first trimester uteroplacental flow and the progressive disintegration of spiral artery plugs: New insights from contrast-enhanced ultrasound and tissue histopathology. Human Reproduction Dec 1;32(12):2382-2393. PMID: 29136193; PMCID: PMC6251668.
  • MC Schabel, VHJ Roberts, JO Lo, S Platt, KA Grant, AE Frias, and CD Kroenke (2015) Functional Imaging of the non-human primate placenta with endogenous BOLD contrast. Magnetic Resonance in Medicine, Nov;76(5):1551-1562. PMID: 26599502; PMCID: PMC4879634.
  • AE Frias, MC Schabel, VHJ Roberts, A Tudorica, PL Grigsby, KY Oh, and CD Kroenke (2015) Using Dynamic Contrast Enhanced MRI to quantitatively characterize maternal vascular organization in the primate placenta. Magnetic Resonance in Medicine, 73(4) 1570-8. PMID: 24753177; PMCID: PMC4487918.

Publications

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