Photo of Timothy J. Nice, Ph.D.

Timothy J. Nice Ph.D.

  • (503) 418-1984
    • Assistant Professor of Molecular Microbiology and Immunology School of Medicine
    • Molecular Microbiology and Immunology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Education

2009 - Molecular and Cellular Biology, Ph.D., University of California at Berkeley
2003 - Genetics, Cell Biology, and Development, B.S., University of Minnesota - Twin Cities

Experience

2015 - present - Assistant Professor, Molecular Microbiology and Immunology, OHSU
2010 - 2015 - Postdoctoral Fellow, Washington University in Saint Louis

Biography

Timothy Nice, Ph.D., is an assistant professor in the department of molecular microbiology and immiunology. His research focuses on host-microbe interactions in the intestine.

The Nice Lab is interested in identifying virus and host genes that determine the outcome of intestinal infection. Understanding the basic functions of these genes in infection and immunity reveal viral and host strategies for survival. Additionally, the lab is interested in how virus-bacteria interactions between the diverse array of microbes that inhabit our intestine impact microbial persistence and the anti-microbial immune response. 

Publications

  • "Type i interferons link viral infection to enhanced epithelial turnover and repair" Cell Host and Microbe January 14 2015
  • "A single-amino-acid change in murine norovirus NS1/2 is sufficient for colonic tropism and persistence" Journal of Virology January 2013
  • "Posttranslational regulation of the NKG2D ligand Multl in response to cell stress" Journal of Experimental Medicine February 16 2009
  • "Interferon-λ" Immunity July 21 2015
  • "Murine norovirus protein NS1/2 aspartate to glutamate mutation, sufficient for persistence, reorients side chain of surface exposed tryptophan within a novel structured domain" Proteins: Structure, Function and Genetics  2014
  • "Interferon-λ cures persistent murine norovirus infection in the absence of adaptive immunity" Science January 16 2015
  • "Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase" Journal of Immunology November 1 2010
  • "Commensal microbes and interferon-λ determine persistence of enteric murine norovirus infection" Science January 16 2015
  • "Virus-helminthcoinfection reveals a microbiota-independent mechanism of immunomodulation" Science August 1 2014
  • "Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity" PLoS Pathogens June 1 2016
  • "Expression of Ifnlr1 on intestinal epithelial cells is critical to the antiviral effects of interferon lambda against norovirus and reovirus" Journal of Virology  2017
  • "You Can Breathe Easy" Immunity May 16 2017
  • "Noroviruses co-opt the function of host proteins VAPA and VAPB for replication via a phenylalanine–phenylalanine- acidic-tract-motif mimic in nonstructural viral protein NS1/2" mBio July 1 2017
  • "Differentiation and Protective Capacity of Virus-Specific CD8+ T Cells Suggest Murine Norovirus Persistence in an Immune-Privileged Enteric Niche" Immunity  2017
  • "Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine" Cell Host and Microbe  2017
  • "The Role of Interferon in Persistent Viral Infection" Trends in Microbiology January 1 2017
  • "Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells" Cell Host and Microbe November 14 2018
  • "HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection" Journal of Virology December 1 2018
  • "A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis" Cell Host and Microbe June 12 2019
  • "IFN-I and IL-22 mediate protective effects of intestinal viral infection" Nature Microbiology January 1 2019
  • "Caspase-mediated cleavage of murine norovirus NS1/2 potentiates apoptosis and is required for persistent infection of intestinal epithelial cells" PLoS Pathogens July 1 2019

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