Photo of Thomas R. Shearer, Ph.D.

Thomas R. Shearer Ph.D.

  • (503) 494-8770

    Portland Campus

    • Professor of Integrative Biosciences School of Dentistry
    • Biochemistry and Molecular Biology Graduate Program School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Areas of interest

  • biochemistry
  • nutrition
  • statistics
  • pharmacology


  • "Selenite cataractogenesis in young rats" Federation Proceedings  1984
  • "Calpain may contribute to hereditary cataract formation in sheep" Investigative Ophthalmology and Visual Science December 2005
  • "Galectin-3 enhances extracellular matrix associations and wound healing in monkey corneal epithelium" Experimental Eye Research August 1 2015
  • "Precipitation of crystallins from young rat lens by endogenous calpain" Experimental Eye Research  1995
  • "Biochemical properties of lens-specific calpain Lp85" Experimental Eye Research January 2006
  • "Activation of calpain in myocardial infarction" Cardiovascular Pathology January 1999
  • "Changes in rat lens calpastatin mrna during aging" Investigative Ophthalmology and Visual Science  1997
  • "Fluoride selenium interaction in the hard and soft tissues of the rat" Journal of Nutrition  1976
  • "Chemical location of cadmium in developing rat molars." Journal of Dental Research March 1982
  • "Occurrence of prevotella nigrescens and prevotella intermedia in infections of endodontic origin" Journal of Endodontics  1997
  • "Evidence for apoptosis in the selenite rat model of cataract" Biochemical and Biophysical Research Communications August 28 2000
  • "Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells" Journal of Ocular Pharmacology and Therapeutics October 1 2009
  • "Bovine dental fluorosis" American Journal of Veterinary Research April 1978
  • "Protein synthesis in the teeth of rats receiving selenium" Federation Proceedings  1976
  • "Deamidation of human βB1 alters the elongated structure of the dimer" Experimental Eye Research  2001
  • "Histologic changes in selenite cortical cataract" Investigative Ophthalmology and Visual Science  1988
  • "A device for measuring the pattern of food and water intake in small laboratory animals" Archives of Oral Biology  1974
  • "State of sulfhydryl in selenite cataract" Toxicology and Applied Pharmacology June 15 1984
  • "Superior prevention of calcium ionophore cataract by E64d" Biochimica et Biophysica Acta - Molecular Basis of Disease December 10 1992
  • "Association of calpain with insoluble pellet of rat lens" Experimental Eye Research  1992
  • "Quantitative analysis of calpain ii mrna in rat tissues" FASEB Journal  1996
  • "Proteolysis by calpain is an underlying mechanism for formation of sugar cataract in rat Lens" Current Eye Research  1995
  • "Establishment of an appropriate animal model for lacritin studies" Experimental Eye Research November 2007
  • "Calpain-induced light scattering in young rat lenses is enhanced by UV-B" Journal of Ocular Pharmacology and Therapeutics  2001
  • "Selenium concentration in human saliva." American Journal of Clinical Nutrition October 1971
  • "Developmental and postdevelopmental uptake of dietary organic and inorganic selenium into the molar teeth of rats" Journal of Nutrition  1975
  • "Crystallin degradation and insolubilization in regions of young rat lens with calcium ionophore cataract" Investigative Ophthalmology and Visual Science  1995
  • "Crystallins from rat lens are especially susceptible to calpain-induced light scattering compared to other species" Current Eye Research August 1996
  • "Cataract and the acceleration of calpain-induced β-crystallin insolubilization occurring during normal maturation of rat lens" Investigative Ophthalmology and Visual Science  1994
  • "Effect of proper dentures on nutritional status." General Dentistry March 1988

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