Stuart Ibsen, Ph.D.

  • Assistant Professor of Biomedical Engineering, School of Medicine
  • CEDAR Member, OHSU Knight Cancer Institute, School of Medicine

Biography

Dr. Stuart Ibsen joined OHSU in 2017 and uses his broad background in physics, engineering, and zoology, to develop comprehensive and novel approaches to study biological questions. His lab focuses on the development of new cancer screening techniques, novel noninvasive neural modulation techniques, and the development of light activatable chemotherapy prodrugs.

Dr. Ibsen received a Ph.D. in zoology from the University of Hawaii studying bioacoustics with a focus on dolphin echolocation. He then received a second Ph.D. in Biomedical Engineering from the University of California San Diego with a focus on drug delivery for chemotherapy applications.

His first postdoc was conducted with Dr. Shrekanth Chalasani at the Salk Institute for Biological Studies developing a technique to genetically sensitize neurons to an ultrasound pulse called Sonogenetics.

He conducted a second postdoc at the UCSD Moores Cancer Center developing a high conductance dielectrophoresis technique to recover drug delivery vehicles from undiluted human plasma.

He conducted a third postdoc at the UCSD Nanoengineering Department developing a high conductance dielectrophoresis technique to collect cancer-derived exosomes from human plasma. He also developed methods for on chip immunostaining of cancer-related proteins on the surface of the exosomes.

Dr. Ibsen conducted his final postdoc at University College London in the UK working with Dr. Stefan Guldin developing therapeutic drug monitoring systems to help identify which cancer patients are high metabolizers of the chemotherapy drug to develop personalized drug dosing.

Honors and awards

  • Highlighted research article in Nature Communications 2015
  • Sonogenetics work featured in The New York Times, the BBC, and Forbes 2015
  • Inside Cover Article for the journal Small 2015
  • NIH Cancer Therapeutics Training Program Fellow Award 2012
  • Salk Institute Pioneer Fund Postdoctoral Scholar Award 2011
  • Cover Article for Journal of Controlled Release 2011
  • NSF Graduate Research Fellow 2003
  • Junior Science and Humanities Symposium - 1st place in chemistry 1998
  • Intel International Science Fair - 1st place and best of category in chemistry 1997

Areas of interest

  • Early Cancer Detection and Treatment
  • Light Activatable Chemotherapy Prodrug Design
  • Dielectrophoresis Based Collection of Cancer Derived Biomarkers for Rapid Cancer Screening
  • Sonogenetics
  • Bioacoustics

Publications

Selected publications

  • Ibsen, Stuart; Wright, Jennifer; Lewis, Jean; Kim, Sejung; Ko, Seo-Yeon; Ong, Jiye; Manouchehri, Sareh; Vyas, Ankit; Akers, Johnny; Chen, Clark; Carter, Bob; Esener, Sadik; Heller, Michael."Rapid isolation and detection of exosomes and associated biomarkers from plasma." ACS Nano, Volume 11, Issue 7, pp. 6641-6651 (2017).
  • Ibsen, Stuart; Tong, Ada; Schutt, Carolyn; Esener, Sadik; Chalasani, Sreekanth. "Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans." Nature Communications, Volume 6 (2015).
  • Ibsen, Stuart; Sonnenberg, Avery; Ibsen, Carolyn; Mukthavaram, Rajesh; Yeh, Yasan; Ortac, Inanc; Manouchehri, Sareh; Kesari, Santosh; Esener, Sadik; Heller, Michael. "Recovery of Drug Delivery Nanoparticles from Human Plasma using an Electrokinetic Platform Technology." Small, (2015).
  • Ibsen, Stuart; Zahavy, Eran; Wrasidlo, Wolf; Hayashi, Tomoko; Norton, John; Su, Yongxuan; Adams, Stephen; Esener, Sadik. "Localized In Vivo Activation of a Photoactivatable Doxorubicin Prodrug in Deep Tumor Tissue." Photochemistry and Photobiology, Volume 89, Issue 3, pp. 698–708 (2013).
  • Ibsen, Stuart; Zahavy, Eran; Wrasidlo, Wolf; Berns, Michael; Chan, Michael; Esener, Sadik. "A Novel Doxorubicin Prodrug with Controllable Photolysis Activation for Cancer Chemotherapy." Pharmaceutical Research, Volume 27, Issue 9, pp. 1848-60 (2010).
  • Ibsen, Stuart; Au, Whitlow; Nachtigall, Paul; DeLong, Caroline; Breese, Marlee. "Changes in consistency patterns of click frequency content over time of an echolocating Atlantic bottlenose dolphin." Journal of the Acoustical Society of America, Volume 127, Issue 6, pp. 3821-3829 (2010).
  • Ibsen, Stuart; Au, Whitlow; Nachtigall, Paul; Breese, Marlee. "Functional bandwidth of an echolocating Atlantic bottlenose dolphin (Tursiops truncatus)." Journal of the Acoustical Society of America, Volume 125, Issue 2, pp. 1214-1221 (2009)

Publications

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