Photo of Stephen A. Back, M.D., Ph.D.

Stephen A. Back M.D., Ph.D.

  • (503) 346-0640
    • Professor of Pediatrics School of Medicine
    • Clyde and Elda Munson Professor of Pediatric Research Pediatrics School of Medicine

The Back Lab focuses on the development of novel strategies to promote regeneration and repair of injury to the developing brain. The lab studies mechanisms by which hypoxia-ischemia triggers cerebral white matter injury, the major cause of cerebral palsy (CP) in survivors of preterm birth. We focus on the oligodendrocyte lineage, as well as several other key cellular components of the white matter. We use several complementary approaches that employ human tissues, tissue culture systems and unique animal models. We also extend these developmental observations to define mechanisms of white matter injury in adult CNS in disorders that include multiple sclerosis and Alzheimer's disease.

Education

  • M.D., University of California at Davis School of Medicine 1990
  • Residency:

    • University of California, Irvine Medical Center
  • Fellowship:

    • Fellowship in pediatric neurology, Harvard Medical School
  • Certifications:

    • Pediatric neurology, 1997

Publications

  • "A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors." Journal of Clinical Investigation  In: , Vol. 128, No. 5, 01.05.2018, p. 2025-2041.
  • "Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matter." Annals of Neurology  In: , Vol. 83, No. 1, 01.01.2018, p. 142-152.
  • "Brain Injury in the Preterm Infant."   Avery's Diseases of the Newborn: Tenth Edition. Elsevier Inc., 2017. p. 879-896.e6.
  • "Transient hypoxemia chronically disrupts maturation of preterm fetal ovine subplate neuron arborization and activity." Journal of Neuroscience  In: , Vol. 37, No. 49, 06.12.2017, p. 11912-11929.
  • "Encephalopathy of Prematurity : Pathophysiology. Pathophysiology."   Volpe's Neurology of the Newborn. Elsevier, 2017. p. 405-424.
  • "Comment on : PH20 is not expressed in murine CNS and oligodendrocyte precursor cells." Annals of Clinical and Translational Neurology  In: , Vol. 4, No. 8, 01.08.2017, p. 608-609.
  • "Translational Stroke Research : Vision and Opportunities." Stroke  In: , 27.07.2017.
  • "White matter injury in the preterm infant : pathology and mechanisms." Acta Neuropathologica  In: , 22.05.2017, p. 1-19.
  • "Prenatal determinants of brain development : Recent studies and methodological advances."   Neuromethods. Vol. 109 Humana Press Inc., 2016. p. 303-326 (Neuromethods; Vol. 109).
  • "Unbiased stereological analysis of reactive astrogliosis to estimate age-associated cerebral white matter injury." Journal of Neuropathology and Experimental Neurology  In: , Vol. 75, No. 6, 01.06.2016, p. 539-554.
  • "Controversies in preterm brain injury." Neurobiology of Disease  In: , Vol. 92, No. Part A, 2016, p. 90-101.
  • "An update on research priorities in hydrocephalus : Overview of the third National Institutes of Health-sponsored symposium "opportunities for Hydrocephalus Research: Pathways to Better Outcomes"." Journal of Neurosurgery  In: , Vol. 123, No. 6, 01.12.2015, p. 1427-1438.
  • "The sheep as a model of brain injury in the premature infant."   Neuromethods. Vol. 104 Humana Press Inc., 2015. p. 107-128 (Neuromethods; Vol. 104).
  • "Brain injury in the preterm infant : New horizons for pathogenesis and prevention." Pediatric Neurology  In: , Vol. 53, No. 3, 01.09.2015, p. 185-192.
  • "Disease specific therapies in leukodystrophies and leukoencephalopathies." Molecular Genetics and Metabolism  In: , Vol. 114, No. 4, 01.04.2015, p. 527-536.
  • "Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases." International Journal of Cell Biology  In: , Vol. 2015, 368584, 2015.
  • "Role of recurrent hypoxia-ischemia in preterm white matter injury severity." PLoS One  In: , Vol. 9, No. 11, e112800, 12.11.2014.
  • "Cerebral White and Gray Matter Injury in Newborns : New Insights into Pathophysiology and Management." Clinics in Perinatology  In: , Vol. 41, No. 1, 03.2014, p. 1-24.
  • "Advances in Neonatal Neurology." Clinics in Perinatology  In: , Vol. 41, No. 1, 03.2014, p. 17-19.
  • "Prenatal cerebral ischemia triggers dysmaturation of caudate projection neurons." Annals of Neurology  In: , Vol. 75, No. 4, 2014, p. 508-524.
  • "Isoflurane-induced apoptosis of neurons and oligodendrocytes in the fetal rhesus macaque brain." Anesthesiology  In: , Vol. 120, No. 3, 2014, p. 626-638.
  • "What brakes the preterm brain? An arresting story." Pediatric Research  In: , Vol. 75, No. 1-2, 2014, p. 227-233.
  • "Pathophysiology of glia in perinatal white matter injury." GLIA  In: , Vol. 62, No. 11, 2014, p. 1790-1815.
  • "Unmyelinated axon loss with postnatal hypertonia after fetal hypoxia." Annals of Neurology  In: , Vol. 75, No. 4, 2014, p. 533-541.
  • "Brain injury in premature neonates : A primary cerebral dysmaturation disorder?" Annals of Neurology  In: , Vol. 75, No. 4, 2014, p. 469-486.
  • "Hemodynamic and metabolic correlates of perinatal white matter injury severity." PLoS One  In: , Vol. 8, No. 12, e82940, 11.12.2013.
  • "Digestion products of the PH20 hyaluronidase inhibit remyelination." Annals of Neurology  In: , Vol. 73, No. 2, 02.2013, p. 266-280.
  • "Prenatal cerebral ischemia disrupts MRI-defined cortical microstructure through disturbances in neuronal arborization." Science Translational Medicine  In: , Vol. 5, No. 168, 16.01.2013.
  • "Human neural stem cells induce functional myelination in mice with severe dysmyelination (Science Translational Medicine (2012) 4, (165er7))." Science Translational Medicine  In: , Vol. 4, No. 165, 165er7, 19.12.2012.
  • "Central axons preparing to myelinate are highly sensitivity to ischemic injury." Annals of Neurology  In: , Vol. 72, No. 6, 12.2012, p. 936-951.

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