Photo of Shoukhrat Mitalipov, Ph.D.

Shoukhrat Mitalipov Ph.D.

    • Professor Oregon National Primate Research Center
    • Professor of Obstetrics and Gynecology School of Medicine
    • Professor and Director GT.Center for Embryonic Cell & Gene Therapy
    • Program in Molecular and Cellular Biosciences School of Medicine

Shoukhrat Mitalipov is the Director of the OHSU Center for Embryonic Cell and Gene Therapy. He is also a Professor in the Division of Reproductive & Developmental Sciences of Oregon National Primate Research Center. After receiving his Ph.D. degree, he came to Utah State University in 1995 to conduct his postdoctoral training in developmental biology. Dr. Mitalipov joined OHSU in 1998.

Areas of interest

  • Gamete and Embryo Biology
  • Mitochondrial Genetics
  • Special focus on Germline Gene Therapy

Education

  • M.S., Timiriasev Academy, Moscow Russian Federation 1987
  • Ph.D., Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow Russian Federation 1994
  • Fellowship:

    • Postdoctoral Fellow, Dept of Animal, Dairy and Veterinary Sciences, Utah State University, 1995-1998
    • Postdoctoral Fellow, Institute of Human Genetics, Muenster University, Muenster, Germany, 1995

Honors and awards

  • 2013 – Recognized by journal Nature as top 10 people who mattered in 2013
  • 2010 – Recipient of the 2010 Discovery Award, The Medical Research Foundation of Oregon
  • 2010 – Recipient of 2010 Women’s Health Research Award, the Center for Women’s Health, Circle of Giving
  • 1995 – Fellowship award, Exchange Visitor Program “Cooperation in Applied Sciences and Technologies (CAST)”. Development of culture system to maintain pluripotency of bovine embryonic stem cells. Utah State University.
  • 2017 - Recipient of “Thousand Talents Plan” Award in China in the category of the Recruitment Program for Foreign Experts

Publications

Selected publications

  • Ma H, Marti-Gutierrez N, Park SW, Wu J, Lee Y, Suzuki K, Koski A, Ji D, Hayama T, Ahmed R, Darby H, Van Dyken C, Li Y, Kang E, Park AR, Kim D, Kim ST, Gong J, Gu Y, Xu X, Battaglia D, Krieg SA, Lee DM, Wu DH, Wolf DP, Heitner SB, Belmonte JCI, Amato P, Kim JS, Kaul S, Mitalipov S. Correction of a pathogenic gene mutation in human embryos. Nature. 2017;548(7668):413-419. PMID: 28783728.

  • Kang E, Wu J, Gutierrez NM, Koski A, Tippner-Hedges R, Agaronyan K, Platero-Luengo A, Martinez-Redondo P, Ma H, Lee Y, Hayama T, Van Dyken C, Wang X, Luo S, Ahmed R, Li Y, Ji D, Kayali R, Cinnioglu C, Olson S, Jensen J, Battaglia D, Lee D, Wu D, Huang T, Wolf DP, Temiakov D, Belmonte JC, Amato P, Mitalipov S. Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. Nature. 2016;540(7632):270-275. PMID: 27919073.

  • Kang E, Wang X, Tippner-Hedges R, Ma H, Folmes CD, Gutierrez NM, Lee Y, Van Dyken C, Ahmed R, Li Y, Koski A, Hayama T, Luo S, Harding CO, Amato P, Jensen J, Battaglia D, Lee D, Wu D, Terzic A, Wolf DP, Huang T, Mitalipov S. Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs. Cell Stem Cell. 2016;18(5):625-636. PMID: 27151456.

  • Ma H, Folmes CD, Wu J, Morey R, Mora-Castilla S, Ocampo A, Ma L, Poulton J, Wang X, Ahmed R, Kang E, Lee Y, Hayama T, Li Y, Van Dyken C, Gutierrez NM, Tippner-Hedges R, Koski A, Mitalipov N, Amato P, Wolf DP, Huang T, Terzic A, Laurent LC, Izpisua Belmonte JC, Mitalipov S. Metabolic rescue in pluripotent cells from patients with mtDNA disease. Nature. 2015;524(7564):234-238. PMID: 26176921.

  • Ma H, Morey R, O'Neil RC, He Y, Daughtry B, Schultz MD, Hariharan M, Nery JR, Castanon R, Sabatini K, Thiagarajan RD, Tachibana M, Kang E, Tippner-Hedges R, Ahmed R, Gutierrez NM, Van Dyken C, Polat A, Sugawara A, Sparman M, Gokhale S, Amato P, Wolf DP, Ecker JR, Laurent LC, Mitalipov S. Abnormalities in human pluripotent cells due to reprogramming mechanisms. Nature. 2014;511(7508):177-183. PMCID: PMC4898064.

  • Kang E, Wu G, Ma H, Li Y, Tippner-Hedges R, Tachibana M, Sparman M, Wolf DP, Scholer HR, Mitalipov S. Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos. Nature. 2014;509(7498):101-104. PMCID: PMC4124901.

  • Tachibana M, Amato P, Sparman M, Gutierrez NM, Tippner-Hedges R, Ma H, Kang E, Fulati A, Lee HS, Sritanaudomchai H, Masterson K, Larson J, Eaton D, Sadler-Fredd K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer RL, Wolf D, Mitalipov S. Human embryonic stem cells derived by somatic cell nuclear transfer. Cell. 2013;153(6):1228-1238. PMCID: PMC3772789.

  • Tachibana M, Amato P, Sparman M, Woodward J, Sanchis DM, Ma H, Gutierrez NM, Tippner-Hedges R, Kang E, Lee HS, Ramsey C, Masterson K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer R, Mitalipov S. Towards germline gene therapy of inherited mitochondrial diseases. Nature. 2013;493(7434):627-631. PMCID: PMC3561483.

  • Tachibana M, Sparman M, Sritanaudomchai H, Ma H, Clepper L, Woodward J, Li Y, Ramsey C, Kolotushkina O, Mitalipov S. Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature. 2009;461(7262):367-372. PMCID: PMC2774772.

  • Kang E, Wu J, Gutierrez NM, Koski A, Tippner-Hedges R, Agaronyan K, Platero-Luengo A, Martinez-Redondo P, Ma H, Lee Y, Hayama T, Van Dyken C, Wang X, Luo S, Ahmed R, Li Y, Ji D, Kayali R, Cinnioglu C, Olson S, Jensen J, Battaglia D, Lee D, Wu D, Huang T, Wolf DP, Temiakov D, Belmonte JC, Amato P, Mitalipov S. Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. Nature. 2016;540(7632):270-275. PMID: 27919073.

Publications

  • "Germline and somatic mtDNA mutations in mouse aging." PLoS One  In: , Vol. 13, No. 7, e0201304, 01.07.2018.
  • "Allogeneic iPSC-derived RPE cell graft failure following transplantation into the subretinal space in nonhuman primates." Investigative Ophthalmology and Visual Science  In: , Vol. 59, No. 3, 01.03.2018, p. 1374-1383.
  • "Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 114, No. 52, 26.12.2017, p. E11111-E11120.
  • "Corrigendum to : Mitochondrial genome inheritance and replacement in the human germline (The EMBO Journal, (2017), 36, 15, (2177-2181), 10.15252/embj.201797606)." EMBO Journal  In: , Vol. 36, No. 17, 01.09.2017, p. 2659.
  • "Correction of a pathogenic gene mutation in human embryos." Nature  In: , Vol. 548, No. 7668, 24.08.2017, p. 413-419.
  • "Functional Human Oocytes Generated by Transfer of Polar Body Genomes." Cell Stem Cell  In: , Vol. 20, No. 1, 05.01.2017, p. 112-119.
  • "Mitochondrial genome inheritance and replacement in the human germline." EMBO Journal  In: , 2017.
  • "Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations." Nature  In: , Vol. 540, No. 7632, 08.12.2016, p. 270-275.
  • "Mitochondria in pluripotent stem cells : Stemness regulators and disease targets." Current Opinion in Genetics and Development  In: , Vol. 38, 01.06.2016, p. 1-7.
  • "Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer : A Horse in the Race?" Stem Cells  In: , 2016.
  • "Incompatibility between Nuclear and Mitochondrial Genomes Contributes to an Interspecies Reproductive Barrier." Cell Metabolism  In: , 12.11.2015.
  • "Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs." Cell Stem Cell  In: , 01.09.2015.
  • "Metabolic rescue in pluripotent cells from patients with mtDNA disease." Nature  In: , Vol. 524, No. 7564, 13.08.2015, p. 234-238.
  • "Corrigendum to Brains, Genes, and Primates [Neuron 86, 617-631; May 6, 2015]." Neuron  In: , Vol. 87, No. 3, 05.08.2015, p. 671.
  • "Brains, Genes, and Primates." Neuron  In: , Vol. 86, No. 3, 06.05.2015, p. 617-631.
  • "Mitochondrial replacement therapy in reproductive medicine." Trends in Molecular Medicine  In: , Vol. 21, No. 2, 01.02.2015, p. 68-76.
  • "Erratum : Mitochondrial gene replacement in primate offspring and embryonic stem cells (Nature (2009) 461 367-372 DOI:10.1038/nature08368)." Nature  In: , Vol. 516, No. 7530, 11.12.2014, p. 276.
  • "Erratum : Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos (Nature (2014) 509 (101-104) DOI:10.1038/nature13134)." Nature  In: , Vol. 516, No. 7530, 11.12.2014, p. 276.
  • "Erratum : Producing primate embryonic stem cells by somatic cell nuclear transfer (Nature (2007) 450 (497-502) DOI:10.1038/nature06357)." Nature In: , Vol. 516, No. 7530, 11.12.2014, p. 276.
  • "Mitochondrial replacement therapies can circumvent mtDNA-based disease transmission." Cell Metabolism  In: , Vol. 20, No. 1, 01.07.2014, p. 6-8.
  • "Limitations of preimplantation genetic diagnosis for mitochondrial DNA diseases." Cell Reports In: , Vol. 7, No. 4, 22.05.2014, p. 935-937.
  • "Clinical and ethical implications of mitochondrial gene transfer." Trends in Endocrinology and Metabolism In: , Vol. 25, No. 1, 01.2014, p. 5-7.
  • "Three-parent in vitro fertilization : Gene replacement for the prevention of inherited mitochondrial diseases." Fertility and Sterility  In: , Vol. 101, No. 1, 01.2014, p. 31-35.
  • "Abnormalities in human pluripotent cells due to reprogramming mechanisms." Nature  In: , Vol. 511, No. 7508, 2014, p. 177-183.
  • "Comparable frequencies of coding mutations and loss of imprinting in human pluripotent cells derived by nuclear transfer and defined factors." Cell Stem Cell  In: , Vol. 15, No. 5, 2014, p. 634-642.
  • "Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos." Nature  In: , Vol. 508, No. 7498, 2014, p. 101-104.
  • "Concise review : Parthenote stem cells for regenerative medicine: Genetic, epigenetic, and developmental features." Stem cells translational medicine  In: , Vol. 3, No. 3, 2014, p. 290-298.
  • "The Challenges of Mitochondrial Replacement." PLoS Genetics In: , Vol. 10, No. 4, e1004315, 2014.
  • "Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy." Proceedings of the National Academy of Sciences of the United States of America  In: , Vol. 110, No. 52, 24.12.2013, p. 21030-21035.
  • "Cloning Primates."   Principles of Cloning: Second Edition. Elsevier Inc., 2013. p. 299-310.

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