Selva Baltan, M.D., Ph.D.

  • Professor of Anesthesiology and Perioperative Medicine, School of Medicine
  • Vice Chair for Basic Science Research, Anesthesiology and Perioperative Medicine, School of Medicine

Biography

Dr. Baltan is Professor and Vice Chair for Research of Anesthesiology and PeriOperative Medicine (APOM) at Oregon Health & Science University (OHSU). Dr. Baltan grew up in Ankara, Turkey and earned her medical degree from Hacettepe University, Ankara, Turkey and a PhD in Neurophysiology from McGill University, Montreal, Canada. After completing an American Heart and Stroke fellowship at Neurology Department at Washington University, St. Louis, MO she joined Neurology Department at University of Washington, Seattle, WA and continued to her academic career as Assistant Professor and Associate Professor. In 2011 Dr. Baltan joined Neurosciences and Neurological Institute at the Cleveland Clinic until she joined OHSU in 2019 as Professor and Vice Chair of Basic Research. Dr. Baltan serves on the editorial boards of several journals including Conditional Medicine and Translational Stroke Research. She is a member of the American Heart Association Brain and Stroke Study Section and the National Institutes of Health Brain Injury and Neurovascular Pathologies (BINP) Study Section. Her research focuses on mechanisms of white matter injury to develop ideal stroke therapeutics that are directed towards neuronal and axonal protection across age, to restore function when applied after injury. Experimental approaches in her lab include optic nerve and corpus callosum slice models, employing electrophysiological recordings, and advanced microscopy techniques such as confocal, two-photon microscopy and 3D electron microscopy. The current focus of her lab is on elucidating the mechanisms of preconditioning conferred by Class I HDAC inhibition in young and aging white matter and the gene regulatory mechanisms underlying this protective phenomenon. Studying on the role of protein acetylation and mitochondrial dynamics in white matter stroke expands her findings to neurodegenerative diseases such as Multiple Sclerosis and Alzheimer ’s disease that involve white matter. Her research is funded by multiple NIH grants.

Education

  • M.D., 1990, Hacettepe University
  • Ph.D., 1998, McGill University

Publications

Selected publications

  • Baltan S. Stroke in CNS white matter: Models and mechanisms 2019. Neurosci Lett. 2019 Aug 1;711:134411.
  • Bastian C, Day J, Politano S, Quinn J, Brunet S, Baltan S . Preserving Mitochondrial Structure and Motility Promotes Recovery of White Matter After Ischemia.Neuromolecular Med. 2019 May 31.
  • Baltan S, Shi Y, Keep RF, Chen J.The effect of aging on brain injury and recovery after stroke.Neurobiol Dis. 2019 Jun;126:1-2.  
  • Bastian C, Politano S, Day J, McCray A, Brunet S, Baltan S. Mitochondrial dynamics and preconditioning in white matter. Cond Med. 2018;1(2):64-72.
  • Baltan S, Bastian C, Quinn J, Aquila D, McCray A, Brunet S. (2018) CK2 inhibition protects white matter from ischemic injury. Neurosci Lett. 687:37-42.
  • Bastian C, Quinn J, Tripathi A, Aquila D, Dutta AMR, Baltan S, Brunet S. (2018) CK2 inhibition confers functional protection to young and aging axons against ischemia by differentially regulating the CDK5 and AKT signaling pathways. Neurobiol Dis. Jun 23. pii: S0969-9961(18)30149-9.
  • Bastian C, Zaleski J, Stahon K, Parr B, McCray A, Day J, Brunet S, Baltan S. (2018) NOS3 Inhibition Confers Post-Ischemic Protection to Young and Aging White Matter Integrity by Conserving Mitochondrial Dynamics and Miro-2 Levels. J Neurosci.38(28):6247-6266.
  • Parpura V, Fisher ES, Lechleiter JD, Schousboe A, Waagepetersen HS, Brunet S, Baltan S, Verkhratsky A. (2017) Glutamate and ATP at the Interface Between Signaling and Metabolism in Astroglia: Examples from Pathology. Neurochem Res. 42(1):19-34. PMID: 26915104; PMCID: PMC5357169
  • Hu X, Hou H, Bastian C, He W, Qiu S, Ge Y, Yin X, Kidd GJ, Brunet S, Trapp BD, Baltan S, Yan R. (2017) BACE1 regulates the proliferation and cellular functions of Schwann cells. Glia 65(5):712-726. PMID: 28191691; PMCID: PMC5357169
  • Provencio JJ, Swank V, Lu H, Brunet S, Baltan S, Khapre RV, Seerapu H, Kokiko-Cochran ON, Lamb BT, Ransohoff RM. (2016) Neutrophil depletion after subarachnoid hemorrhage improves memory via NMDA receptors. Brain Behav Immun. 54:233-42. PMID: 26872422; PMCID: PMC4828315  

Publications

  • {{ pub.journalAssociation.journal.name.text[0].value }}
    1. {{ person.name.firstName }} {{ person.name.lastName }}