Photo of Sean D. Speese, Ph.D.

Sean D. Speese Ph.D.

  • (503) 418-9532
    • Assistant Professor of Neurology School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine
    • Jungers Center for Neurosciences Research

Areas of interest

  • Cell Biology, Genetics, Gene Expression, Neuroscience, Synapse, Glia, Microscopy

Publications

Selected publications

  • Glial Draper Rescues Aβ Toxicity in a Drosophila Model of Alzheimer's Disease.Ray A, Speese SD, Logan MA.J Neurosci. 2017 Dec 6;37(49):11881-11893. doi: 10.1523/JNEUROSCI.0862-17.2017. Epub 2017 Nov 6.PMID: 29109235

  • A novel Drosophila injury model reveals severed axons are cleared through a Draper/MMP-1 signaling cascade.Purice MD, Ray A, Münzel EJ, Pope BJ, Park DJ, *Speese SD, *Logan MA.Elife. 2017 Aug 21;6. pii: e23611. doi: 10.7554/eLife.23611.PMID: 28825401   *co-last authors

  • Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity.Purice MD, Speese SD, Logan MA.Nat Commun. 2016 Sep 20;7:12871. doi: 10.1038/ncomms12871.PMID: 27647497

  • Insulin-like Signaling Promotes Glial Phagocytic Clearance of Degenerating Axons through Regulation of Draper.Musashe DT, Purice MD, Speese SD, Doherty J, Logan MA.Cell Rep. 2016 Aug 16;16(7):1838-50. doi: 10.1016/j.celrep.2016.07.022. Epub 2016 Aug 4.

  • Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling. Speese SD, Ashley J, Jokhi V, Nunnari J, Barria R, Li Y, Ataman B, Koon A, Chang YT, Li Q, Moore MJ, Budnik V.Cell. 2012 May 11;149(4):832-46. doi: 10.1016/j.cell.2012.03.032. 

  • The role of Drosophila Lamin C in muscle function and gene expression.Dialynas G, Speese S, Budnik V, Geyer PK, Wallrath LL.Development. 2010 Sep;137(18):3067-77. doi: 10.1242/dev.048231. Epub 2010 Aug 11.PMID: 20702563

  • UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans.Speese S, Petrie M, Schuske K, Ailion M, Ann K, Iwasaki K, Jorgensen EM, Martin TF.J Neurosci. 2007 Jun 6;27(23):6150-62.PMID: 17553987

  • Wnts: up-and-coming at the synapse. Speese SD, Budnik V.Trends Neurosci. 2007 Jun;30(6):268-75. Epub 2007 Apr 27. Review.PMID: 17467065

  • The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy. Speese SD, Trotta N, Rodesch CK, Aravamudan B, Broadie K.Curr Biol. 2003 May 27;13(11):899-910.PMID: 12781128

Publications

  • "Glial draper rescues Aβ toxicity in a Drosophila model of Alzheimer’s disease." Journal of Neuroscience In: , Vol. 37, No. 49, 06.12.2017, p. 11881-11893.
  • "A novel Drosophila injury model reveals severed axons are cleared through a draper/MMP-1 signaling cascade." eLife In: , Vol. 6, e23611, 21.08.2017.
  • "Protein phosphatase 4 coordinates glial membrane recruitment and phagocytic clearance of degenerating axons in Drosophila." Cell death & disease In: , Vol. 8, No. 2, 23.02.2017, p. e2623.
  • "Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity." Nature Communications In: , Vol. 7, 12871, 20.09.2016.
  • "Insulin-like Signaling Promotes Glial Phagocytic Clearance of Degenerating Axons through Regulation of Draper." Cell Reports In: , Vol. 16, No. 7, 16.08.2016, p. 1838-1850.
  • "Erratum : Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic wnt signaling (Cell 149 (832846) 2012)." Cell  In: , Vol. 151, No. 3, 26.10.2012, p. 687-689.
  • "Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling." Cell  In: , Vol. 149, No. 4, 11.05.2012, p. 832-846.
  • "Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury." Nature Neuroscience In: , Vol. 15, No. 5, 05.2012, p. 722-730.
  • "The role of Drosophila Lamin C in muscle function and gene expression." Development In: , Vol. 137, No. 18, 15.09.2010, p. 3067-3077.
  • "A comparative study of Drosophila and human A-type lamins." PLoS One In: , Vol. 4, No. 10, e7564, 26.10.2009.
  • "UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans." Journal of Neuroscience  In: , Vol. 27, No. 23, 06.06.2007, p. 6150-6162.
  • "Wnts : up-and-coming at the synapse." Trends in Neurosciences  In: , Vol. 30, No. 6, 06.2007, p. 268-275.
  • "Postsynaptic membrane addition depends on the discs-large-interacting t-SNARE Gtaxin." Journal of Neuroscience  In: , Vol. 27, No. 5, 31.01.2007, p. 1033-1044.
  • "Rolling blackout, a newly identified PIP-DAG pathway lipase required for Drosophila phototransduction." Nature Neuroscience  In: , Vol. 7, No. 10, 10.2004, p. 1070-1078.
  • "The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy." Current Biology  In: , Vol. 13, No. 11, 27.05.2003, p. 899-910.
  • "Drosophila fragile x-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function." Cell  In: , Vol. 107, No. 5, 30.11.2001, p. 591-603.
  • "Characterization of two novel lipocalins expressed in the Drosophila embryonic nervous system." International Journal of Developmental Biology In: , Vol. 44, No. 4, 2000, p. 349-359.

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