Photo of Sean D. Speese, Ph.D.

Sean D. Speese Ph.D.

  • (503) 418-9532
    • Assistant Professor of Neurology School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine
    • Jungers Center for Neurosciences Research

Areas of interest

  • Cell Biology, Genetics, Gene Expression, Neuroscience, Synapse, Glia, Microscopy

Publications

Selected publications

  • Glial Draper Rescues Aβ Toxicity in a Drosophila Model of Alzheimer's Disease.Ray A, Speese SD, Logan MA.J Neurosci. 2017 Dec 6;37(49):11881-11893. doi: 10.1523/JNEUROSCI.0862-17.2017. Epub 2017 Nov 6.PMID: 29109235

  • A novel Drosophila injury model reveals severed axons are cleared through a Draper/MMP-1 signaling cascade.Purice MD, Ray A, Münzel EJ, Pope BJ, Park DJ, *Speese SD, *Logan MA.Elife. 2017 Aug 21;6. pii: e23611. doi: 10.7554/eLife.23611.PMID: 28825401   *co-last authors

  • Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity.Purice MD, Speese SD, Logan MA.Nat Commun. 2016 Sep 20;7:12871. doi: 10.1038/ncomms12871.PMID: 27647497

  • Insulin-like Signaling Promotes Glial Phagocytic Clearance of Degenerating Axons through Regulation of Draper.Musashe DT, Purice MD, Speese SD, Doherty J, Logan MA.Cell Rep. 2016 Aug 16;16(7):1838-50. doi: 10.1016/j.celrep.2016.07.022. Epub 2016 Aug 4.

  • Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling. Speese SD, Ashley J, Jokhi V, Nunnari J, Barria R, Li Y, Ataman B, Koon A, Chang YT, Li Q, Moore MJ, Budnik V.Cell. 2012 May 11;149(4):832-46. doi: 10.1016/j.cell.2012.03.032. 

  • The role of Drosophila Lamin C in muscle function and gene expression.Dialynas G, Speese S, Budnik V, Geyer PK, Wallrath LL.Development. 2010 Sep;137(18):3067-77. doi: 10.1242/dev.048231. Epub 2010 Aug 11.PMID: 20702563

  • UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans.Speese S, Petrie M, Schuske K, Ailion M, Ann K, Iwasaki K, Jorgensen EM, Martin TF.J Neurosci. 2007 Jun 6;27(23):6150-62.PMID: 17553987

  • Wnts: up-and-coming at the synapse. Speese SD, Budnik V.Trends Neurosci. 2007 Jun;30(6):268-75. Epub 2007 Apr 27. Review.PMID: 17467065

  • The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy. Speese SD, Trotta N, Rodesch CK, Aravamudan B, Broadie K.Curr Biol. 2003 May 27;13(11):899-910.PMID: 12781128

Publications

  • "Wnts" Trends in Neurosciences June 2007
  • "Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction" Nature Neuroscience October 2004
  • "Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling" Cell May 11 2012
  • "Postsynaptic membrane addition depends on the discs-large-interacting t-SNARE Gtaxin" Journal of Neuroscience January 31 2007
  • "A comparative study of Drosophila and human A-type lamins" PLoS One October 26 2009
  • "The role of Drosophila Lamin C in muscle function and gene expression" Development (Cambridge) September 15 2010
  • "Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury" Nature Neuroscience May 2012
  • "Characterization of two novel lipocalins expressed in the Drosophila embryonic nervous system" International Journal of Developmental Biology  2000
  • "Erratum" Cell October 26 2012
  • "UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans" Journal of Neuroscience June 6 2007
  • "The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy" Current Biology May 27 2003
  • "Drosophila fragile x-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function" Cell November 30 2001
  • "Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity" Nature Communications September 20 2016
  • "Insulin-like Signaling Promotes Glial Phagocytic Clearance of Degenerating Axons through Regulation of Draper" Cell Reports August 16 2016
  • "A novel Drosophila injury model reveals severed axons are cleared through a draper/MMP-1 signaling cascade" eLife August 21 2017
  • "Protein phosphatase 4 coordinates glial membrane recruitment and phagocytic clearance of degenerating axons in Drosophila" Cell Death and Disease February 23 2017
  • "Glial draper rescues Aβ toxicity in a Drosophila model of Alzheimer’s disease" Journal of Neuroscience December 6 2017

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