Photo of Scott W. Wong, Ph.D.

Scott W. Wong Ph.D.

  • (503) 690-5285
    • Professor VGTI-Vaccine and Gene Therapy Institute
    • Molecular Microbiology and Immunology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. Wong received his Ph.D. from Stanford University School of Medicine in 1987 studying eukaryotic DNA replication. Upon completing his degree he performed post-doctoral research at Stanford University and later at Harvard Medical School, where he focused on human herpesvirus replication and pathogenesis. He came to the Oregon Regional Primate Research Center in 1991 as an Assistant Scientist in the Division of Pathobiology and Immunology, and is now a Senior Scientist and interim Division Chief. Dr. Wong’s primary appointment is in the Vaccine and Gene Therapy Institute, where he is a Senior Scientist and a Professor of Molecular Microbiology and Immunology in the OHSU School of Medicine.

Understanding how viruses cause disease is important to the development of effective antiviral therapies and potential vaccines. 

The long-term goal of the Wong laboratory is to understand how viruses cause disease. This is important in developing effective antiviral therapies and potential vaccines. The Wong lab is currently investigating two types of viruses: orthopoxviruses, which induce disease similar to smallpox; and herpesviruses, which can induce severe disease in individuals. Some of these viruses are very specific for their natural hosts, a factor that complicates the ability to study the mechanisms of the human viruses in an animal model. An alternative approach is to utilize animal models that harbor viruses that are closely related to the human virus. One animal model that has proven to be invaluable in understanding the mechanisms of infectious disease and for vaccine development is the nonhuman primate. 

By employing molecular, genetic and virological techniques, members of Dr. Wong’s laboratory examine how these nonhuman primate viruses infect and replicate in cell culture and eventually how they cause illnesses in vivo. They have shown that experimental inoculation of normal monkeys with orthopoxviruses causes disease that is virtually identical to smallpox and have identified novel viral proteins utilizing proteomic analysis that may facilitate disease. Additionally, experimental infection of immunocompromised monkeys with simian herpesviruses results in disease manifestations that closely resemble those observed in humans infected with the human immunodeficiency virus (HIV). Utilizing these techniques they are identifying the viral determinants that contribute to disease and are devising novel recombinant molecules to help prevent viral pathogenesis.

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Areas of interest

  • HIV pathogenesis and vaccine development

Education

  • Ph.D., Stanford University School of Medicine, Stanford California United States 1987

Publications

Selected publications

  • Skalsky RL, Barr SA, Jeffery AJ, Blair T, Estep R, Wong SW. Japanese Macaque Rhadinovirus Encodes a Viral MicroRNA Mimic of the miR-17 Family. JVirol. 2016 Sep 29;90(20):9350-63. doi: 10.1128/JVI.01123-16. PMID: 27512057, PMCID: PMC5044857

  • Blair TC, Manoharan M, Rawlings-Rhea SD, Tagge I, Kohama SG,Hollister-Smith J, Ferguson B, Woltjer RL, Frederick MC, Pollaro J, Rooney WD,Sherman LS, Bourdette DN, Wong SW. Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis. J Neuroimmunol. 2016 Feb15;291:1-10. doi: 10.1016/j.jneuroim.2015.11.026. PMID: 26857488, PMCID: PMC4748211

  • Morin G, Robinson BA, Rogers KS, Wong SW.;A Rhesus Rhadinovirus Viral Interferon (IFN) Regulatory Factor Is Virion Associated and Inhibits the Early IFN Antiviral Response. J Virol. 2015 Aug;89(15):7707-21.doi: 10.1128/JVI.01175-15. PMID: 25972548, PMCID: PMC4505633

Publications

  • "Comparative proteomics of human monkeypox and vaccinia intracellular mature and extracellular enveloped virions" Journal of Proteome Research March 2008
  • "The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4+ T cell loss caused by the simian-human immunodeficiency virus SHIVKU-lbMC33 in pig-tailed macaques" Virology September 1 2003
  • "Analysis of rhesus rhadinovirus microRNAs expressed in virus-induced tumors from infected rhesus macaques" Virology September 30 2010
  • "Human DNA polymerase α" FASEB Journal  1989
  • "Author's correction" Journal of Virology April 2012
  • "Expression of the gibbon ape leukemia virus receptor-1 in rhesus macaque tissues" Journal of Medical Primatology  1997
  • "Serologic evidence for novel poxvirus in endangered red colobus monkeys, Western Uganda" Emerging Infectious Diseases May 2008
  • "Monkeypox virus viral chemokine inhibitor (MPV vCCI), a potent inhibitor of rhesus macrophage inflammatory protein-1" Cytokine August 2008
  • "Rhesus macaque rhadinovirus-associated disease" Current Opinion in Virology June 2013
  • "A G protein-coupled receptor encoded by rhesus rhadinovirus is similar to ORF74 of Kaposi's sarcoma-associated herpesvirus" Journal of Virology February 2003
  • "Induction of B cell hyperplasia in simian immunodeficiency virus- infected rhesus macaques with the simian homologue of Kaposi's sarcoma- associated herpesvirus" Journal of Experimental Medicine September 20 1999
  • "A rhesus rhadinovirus viral interferon (IFN) regulatory factor is virion associated and inhibits the early IFN antiviral response" Journal of Virology  2015
  • "Elements in the Transcriptional Regulatory Region Flanking Herpes Simplex Virus Type 1 oriS Stimulate Origin Function" Journal of Virology May 1991
  • "Deletion of the vpu sequences prior to the env in a simian-human immunodeficiency virus results in enhanced Env precursor synthesis but is less pathogenic for pig-tailed macaques" Virology  2002
  • "BoHV-4-based vector single heterologous antigen delivery protects STAT1(-/-) mice from monkeypoxvirus lethal challenge" PLoS Neglected Tropical Diseases June 18 2015
  • "Fusion of the upstream vpu sequences to the env of simian human immunodeficiency virus (SHIVKU-1bMC33) results in the synthesis of two envelope precursor proteins, increased numbers of virus particles associated with the cell surface and is pathogenic for pig-tailed macaques" Virology May 20 2004
  • "Scrambling of the amino acids within the transmembrane domain of Vpu results in a simian-human immunodeficiency virus (SHIVTM) that is less pathogenic for pig-tailed macaques" Virology August 15 2005
  • "Japanese macaque encephalomyelitis" Annals of Neurology September 2011
  • "Optimization of proteomic sample preparation procedures for comprehensive protein characterization of pathogenic systems" Journal of Biomolecular Techniques December 2008
  • "Modulation of the severe CD4+ T-cell loss caused by a pathogenic simian-human immunodeficiency virus by replacement of the subtype B vpu with the vpu from a subtype C HIV-1 clinical isolate" Virology February 5 2008
  • "Deletion of the monkeypox virus inhibitor of complement enzymes locus impacts the adaptive immune response to monkeypox virus in a nonhuman primate model of infection" Journal of Virology September 2011
  • "Prevalence of viremia and oral shedding of rhesus rhadinovirus and retroperitoneal fibromatosis herpesvirus in large age-structured breeding groups of rhesus macaques (Macaca mulatta)" Comparative Medicine August 2009
  • "Primate models for gammaherpesvirus-associated malignancies"   2009
  • "Viral interferon regulatory factors are critical for delay of the host immune response against rhesus macaque rhadinovirus infection" Journal of Virology March 2012
  • "Identification of the rhesus macaque rhadinovirus lytic origin of DNA replication" Journal of Virology  2001
  • "The rhesus rhadinovirus CD200 homologue affects immune responses and viral loads during in vivo infection" Journal of Virology  2014
  • "Rhesus rhadinovirus establishes a latent infection in B lymphocytes in vivo" Journal of Virology  1999
  • "Rhesus macaque rhadinovirus-associated non-Hodgkin lymphoma" Blood November 15 2008
  • "A simian human immunodeficiency virus with a nonfunctional vpu (ΔvpuSHIVKU-1bMC33) isolated from a macaque with neuroAIDS has selected for mutations in env and nef that contributed to its pathogenic phenotype" Virology March 30 2001
  • "Genomic characterization of japanese macaque rhadinovirus, a novel herpesvirus isolated from a nonhuman primate with a spontaneous inflammatory demyelinating disease" Journal of Virology January 2013

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