Sarah Andres, Ph.D.

  • Assistant Professor of Pediatrics, Division of Gastroenterology, School of Medicine

Biography

Dr. Andres has a long-standing interest in translational research centered on cellular and molecular mechanisms of gastrointestinal homeostasis and disease.  She is particularly interested in extracellular vesicle-mediated communication and post-transcriptional regulation within the GI tract and throughout the body during homeostasis, inflammation, and cancer. In addition to contributing to the scientific community through research, Dr. Andres is a passionate about mentoring and loves to help her trainees succeed in her lab and beyond.

Education

  • B.S., 2008, University of Portland
  • Ph.D., 2014, University of North Carolina at Chapel Hill

Areas of interest

  • Necrotizing enterocolitis
  • Extracellular vesicles
  • Human milk
  • Post-transcriptional regulation
  • Enteroid models
  • Colon cancer

Publications

Selected publications

  • Kelsen JR, Dawany N, Conrad MA, Karakasheva TA, Maurer K, Wei JM, Uman S, Dent MH, Behera R, Bryant LM, Ma X, Moreira L, Chatterji P, Shraim R, Merz A, Mizuno R, Simon LA, Muir AB, Giraudo C, Behrens EM, Whelan KA, Devoto M, Russo PA, Andres SF, Sullivan KE, Hamilton KE. Colonoids From Patients With Pediatric Inflammatory Bowel Disease Exhibit Decreased Growth Associated With Inflammation Severity and Durable Upregulation of Antigen Presentation Genes. Inflamm Bowel Dis. 2021 J
  • Andres SF, Williams KN, Plesset JB, Headd JJ, Mizuno R, Chatterji P, Lento AA, Klein-Szanto AJ, Mick R, Hamilton KE, Rustgi AK. IMP1 3' UTR shortening enhances metastatic burden in colorectal cancer. Carcinogenesis. 2019 Jun 10;40(4):569-579. doi: 10.1093/carcin/bgy153. PubMed PMID: 30407516; PubMed Central PMCID: PMC6556707.
  • Chatterji P, Williams PA, Whelan KA, Samper FC, Andres SF, Simon LA, Parham LR, Mizuno R, Lundsmith ET, Lee DS, Liang S, Wijeratne HS, Marti S, Chau L, Giroux V, Wilkins BJ, Wu GD, Shah P, Tartaglia GG, Hamilton KE. Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1. EMBO Rep. 2019 Jun;20(6). doi: 10.15252/embr.201847074. Epub 2019 May 6. PubMed PMID: 31061170; PubMed Central PMCID: PMC6549032.
  • Chatterji P, Hamilton KE, Liang S, Andres SF, Wijeratne HRS, Mizuno R, Simon LA, Hicks PD, Foley SW, Pitarresi JR, Klein-Szanto AJ, Mah AT, Van Landeghem L, Gregory BD, Lengner CJ, Madison BB, Shah P, Rustgi AK. The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine. Genes Dev. 2018 Aug 1;32(15-16):1020-1034. doi: 10.1101/gad.314369.118. PubMed PMID: 30068703; PubMed Central PMCID: PMC6075153.
  • Andres SF, Williams KN, Rustgi AK. The Molecular Basis of Metastatic Colorectal Cancer. Curr Colorectal Cancer Rep. 2018 Apr;14(2):69-79. doi: 10.1007/s11888-018-0403-z. Epub 2018 Mar 1. PubMed PMID: 30237756; PubMed Central PMCID: PMC6141197.
  • Mizuno R, Chatterji P, Andres S, Hamilton K, Simon L, Foley SW, Jeganathan A, Gregory BD, Madison B, Rustgi AK. Differential Regulation of LET-7 by LIN28B Isoform-Specific Functions. Mol Cancer Res. 2018 Mar;16(3):403-416. doi: 10.1158/1541-7786.MCR-17-0514. Epub 2018 Jan 12. PubMed PMID: 29330293; PubMed Central PMCID: PMC5835183.
  • Moorefield EC, Andres SF, Blue RE, Van Landeghem L, Mah AT, Santoro MA, Ding S. Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells. Aging (Albany NY). 2017 Aug 29;9(8):1898-1915. doi: 10.18632/aging.101279. PubMed PMID: 28854151; PubMed Central PMCID: PMC5611984.
  • Hamilton KE, Chatterji P, Lundsmith ET, Andres SF, Giroux V, Hicks PD, Noubissi FK, Spiegelman VS, Rustgi AK. Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon. Mol Cancer Res. 2015 Nov;13(11):1478-86. doi: 10.1158/1541-7786.MCR-15-0224. Epub 2015 Jul 20. PubMed PMID: 26194191; PubMed Central PMCID: PMC4644674.
  • Santoro MA, Blue RE, Andres SF, Mah AT, Van Landeghem L, Lund PK. Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon. Am J Physiol Gastrointest Liver Physiol. 2015 Oct 1;309(7):G578-89. doi: 10.1152/ajpgi.00189.2015. Epub 2015 Aug 6. PubMed PMID: 26251471; PubMed Central PMCID: PMC4593818.
  • Andres SF, Santoro MA, Mah AT, Keku JA, Bortvedt AE, Blue RE, Lund PK. Deletion of intestinal epithelial insulin receptor attenuates high-fat diet-induced elevations in cholesterol and stem, enteroendocrine, and Paneth cell mRNAs. Am J Physiol Gastrointest Liver Physiol. 2015 Jan 15;308(2):G100-11. doi: 10.1152/ajpgi.00287.2014. Epub 2014 Nov 13. PubMed PMID: 25394660; PubMed Central PMCID: PMC4297856.

Publications

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