Sancy Leachman, M.D., Ph.D. (she/her)
- Adjunct Professor of Dermatology, School of Medicine
Biography
Sancy Leachman, M.D., Ph.D., is a physician-scientist who holds an Adjunct Professor role in the Department of Dermatology at OHSU.
Her clinical interests include skin cancers, especially melanoma, pigmentary disorders that result from abnormalities of melanocytes such as vitiligo, and genetic disorders that involve the skin such as pachyonychia congenita, Cowden syndrome, and other cutaneous cancer syndromes. In addition to seeing patients with pigmentary disorders, she sees general dermatology patients at the Center for Health & Healing, the Lake Oswego dermatology clinic and in our multidisciplinary melanoma clinic.
Dr. Leachman’s research interest is in the prevention, early detection and chemoprevention of melanoma, particularly in genetically predisposed melanoma families. One arm of her research program examines the role of genetic predisposition and differential gene expression in the development of melanoma, with an emphasis on familial melanoma and other cutaneous cancer syndromes. Through collaborations with Dr. Cassidy, she seeks to develop agents that will serve as diagnostic tools, prognostic indicators or targeted agents for the prevention of melanoma.
Leachman is passionate about fighting the “War on Melanoma” and has led the effort to build one of the largest national melanoma patient registries in Oregon. In line with the OHSU Knight Cancer Institute’s focus on the early detection of cancer, Leachman and team have developed a mobile phone app, MoleMapper, which tracks moles and their change and growth over time. MoleMapper will help to gather data for melanoma research and, potentially, impact health outcomes in individuals at risk. Leachman collaborated with the AIM at Melanoma Foundation to help spearhead the world's first collaborative Melanoma Tissue Bank Consortium, collecting fresh-frozen primary melanoma tissue samples for use in research. Dr. Leachman and team also launched the Start Seeing Melanoma™ public health outreach campaign to increase melanoma awareness and early detection education to Oregonians.
Prior to joining OHSU in 2013, Dr. Leachman was at the University of Utah, where she was director of the Melanoma and Cutaneous Oncology Program in the Huntsman Cancer Institute, a professor in the Department of Dermatology, and member of the Imaging, Diagnostics, and Therapeutics Program and the Cancer Control and Population Sciences Program.
Leachman was a key figure in developing the Melanoma and Cutaneous Oncology Program at Huntsman Cancer Institute. We are excited to have her talent in team building in Oregon to improve the care of patients in our community by bringing together researchers and physicians with an interest in melanoma and other skin cancers in order to bring knowledge and expertise from the laboratory into the clinical realm.
Leachman also worked on a DNA vaccination study to prevent and treat papillomavirus-induced squamous cell carcinoma at Yale University School of Medicine where she completed her residency training and research fellowship. Leachman was awarded the prestigious Doris Duke Clinical Scientist Development Award in 2000 and is currently an NIH R01- and Department of Defense-funded principle investigator.
Education and training
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Degrees
- B.A., 1985, University of Texas at Austin Plan II
- M.D., Ph.D., 1993, University of Texas Southwestern Medical School
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Residency
- Yale-New Haven Hospital (dermatology), New Haven, CT
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Fellowship
- Yale University School of Medicine (cutaneous oncology), New Haven, CT
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Certifications
- American Board of Dermatology
Memberships and associations:
- American Medical Association
- American Academy of Dermatology
- Society for Investigative Dermatology
- Intermountain Dermatology Society
- National Vitiligo Foundation
- Utah Medical Association
- Vitiligo Society
- American Association for Cancer Research
- American Society of Human Genetics
- Pan American Society for Pigment Cell Research
- Utah Society of Dermatologic Medicine and Surgery
- Medical Dermatology Society
- Southwest Oncology Group
- Oregon Dermatology Society
Additional information
Publications
Elsevier pure profileSelected publications
- Revised nomenclature and classification of inherited ichthyoses: results of the First Ichthyosis Consensus Conference in Soreze 2009 V Oji, G Tadini, M Akiyama, CB Bardon, C Bodemer, E Bourrat, ... Journal of the American Academy of Dermatology 63 (4), 607-641
- Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents AM Goldstein, M Chan, M Harland, NK Hayward, F Demenais, DT Bishop, ... Journal of medical genetics 44 (2), 99-106
- High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMEL AM Goldstein, M Chan, M Harland, EM Gillanders, NK Hayward, MF Avril, ... Cancer research 66 (20), 9818-9828
- First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder SA Leachman, RP Hickerson, ME Schwartz, EE Bullough, SL Hutcherson, ... Molecular Therapy 18 (2), 442-446
- Metastatic melanoma in pregnancy: risk of transplacental metastases in the infant A Alexander, WE Samlowski, D Grossman, CS Bruggers, RM Harris, ... Journal of clinical oncology 21 (11), 2179-2186
- Preservation of RNA for functional genomic studies: a multidisciplinary tumor bank protocol SR Florell, CM Coffin, JA Holden, JW Zimmermann, JW Gerwels, ... Modern pathology 14 (2), 116-128
- Melanocytes as instigators and victims of oxidative stress L Denat, AL Kadekaro, L Marrot, SA Leachman, ZA Abdel-Malek Journal of Investigative Dermatology 134 (6), 1512-1518
- Clinical and pathological features of pachyonychia congenita SA Leachman, RL Kaspar, P Fleckman, SR Florell, FJD Smith, ... Journal of Investigative Dermatology Symposium Proceedings 10 (1), 3-17
- Selection criteria for genetic assessment of patients with familial melanoma SA Leachman, J Carucci, W Kohlmann, KC Banks, MM Asgari, ... Journal of the American Academy of Dermatology 61 (4), 677. e1-677. e14
- Evaluation of a 7-day continuous intravenous infusion of decitabine: inhibition of promoter-specific and global genomic DNA methylation WE Samlowski, SA Leachman, M Wade, P Cassidy, P Porter-Gill, L Busby, ... J Clin Oncol 23 (17), 3897-3905