Photo of Robert E. Shangraw, M.D., Ph.D.

Robert E. Shangraw M.D., Ph.D.

    • Professor of Anesthesiology and Perioperative Medicine School of Medicine

Dr. Shangraw has clinical interest in the anesthetic and perioperative care of patients undergoing neurosurgery, major spine surgery and major abdominal surgery including liver transplantation. He has a longstanding interest in the control of glucose metabolism in patients undergoing major surgery and how better control affects clinical outcome. 

Education

  • B.S., Rensselaer Polytechnic Institute 1976
  • Ph.D., Albany Medical College 1981
  • M.D., Albany Medical College 1985
  • Residency:

    • Surgery, University of Washington, 1986
  • Fellowship:

    • Metabolism, University of Texas Medical Branch, 1987
  • Certifications:

    • American Board of Anesthesiology, 1991

Publications

  • "Oxygen consumption and oxygen delivery" Journal of Critical Care  1994
  • "Mechanism of dichloroacetate-induced hypolactatemia in humans with or without cirrhosis" Metabolism: Clinical and Experimental August 2004
  • "Altered protein kinetics in vivo after single-limb burn injury" Biochemical Journal  1984
  • "Bed-rest-induced insulin resistance occurs primarily in muscle" Metabolism: Clinical and Experimental  1988
  • "Glucose-insulin-potassium regimes during cardiac surgery [8]" Anesthesia and Analgesia  1993
  • "Managing intergenerational differences in academic anesthesiology" Current Opinion in Anaesthesiology December 2007
  • "Kinetics of palmitate metabolism in patients before and after liver transplantation" FASEB Journal  1996
  • "Dichloroacetate stabilizes the intraoperative acid-base balance during liver transplantation" Liver Transplantation July 2008
  • "Amelioration of lactic acidosis with dichloroacetate during liver transplantation in humans" Anesthesiology  1994
  • "Effects of leucine on thermally-injured skeletal muscle" Physiologist  1980
  • "Pharmacokinetics and pharmacodynamics of dichloroacetate in patients with cirrhosis" Clinical Pharmacology and Therapeutics  1999
  • "Energy metabolism of vascular smooth muscle and circulating vasoactive substances in hemorrhagic shock in the dog" Journal of inflammation  1980
  • "Differential actions of branched-chain amino acids on proteolysis by muscle from burned rats" Physiologist  1981
  • "Metabolic issues in liver transplantation" International Anesthesiology Clinics September 2006
  • "Insulin responsiveness of protein metabolism in vivo following bedrest in humans" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  1988
  • "Pyruvate dehydrogenase inactivity is not responsible for sepsis-induced insulin resistance" Critical Care Medicine April 1996
  • "Metabolism during liver transplantation" Anesthesia and Analgesia October 1997
  • "Local response of muscle to burns" Journal of Parenteral and Enteral Nutrition May 1981
  • "Hepatic pyruvate dehydrogenase activity in humans" American Journal of Physiology - Renal Fluid and Electrolyte Physiology March 1998
  • "Effect of short-term drinking water exposure to dichloroacetate on its pharmacokinetics nd oral bioavailability in human volunteers" Toxicological Sciences July 2006
  • "Should acidosis during liver transplantation be treated? [4]" Anesthesiology  1995
  • "Effect of disuse and thermal injury on protein turnover in skeletal muscle" Journal of Surgical Research  1982
  • "Effect of dietary protein on bed-rest-related changes in whole-body-protein synthesis" American Journal of Clinical Nutrition September 1990
  • "Dichloroacetate reduces plasma lactate levels but does not reduce infarct size in rabbit myocardium" Shock  1996
  • "Evaluation of postburn protein turnover by skeletal muscle in vivo" Federation Proceedings  1984
  • "Biphasic alterations in glucose metabolism by soleus muscle from the burned limb." Advances in shock research  1979
  • "Valine and isoleucine inhibit glucose uptake and alanine release by thermally injured muscle" Physiologist  1980
  • "Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus" Journal of Cerebral Blood Flow and Metabolism October 2013
  • "Differentiation between septic and postburn insulin resistance" Metabolism: Clinical and Experimental  1989
  • "Role of insulin and glucose oxidation in mediating the protein catabolism of burns and sepsis" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  1989

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