Photo of Rebecca Spain, M.D., M.S.P.H.

Rebecca Spain M.D., M.S.P.H.

Dr. Spain specializes in multiple sclerosis. She received her medical degree in 2002 from the Case Western Reserve University School of Medicine in Cleveland, OH. She completed her neurology residency and  neuroimmunology fellowship at Thomas Jefferson University in Philadelphia, PA. Dr. Spain’s research interests include treating progressive forms of MS and evaluating mobility in MS.

Education

  • M.D., Case Western University School of Medicine, 2002, Cleveland Ohio 2002
  • M.P.H.S., Thomas Jefferson University, 2009, Philadelphia Pennsylvania 2009
  • Internship:

    • Brown university, Providence, RI, 2002
  • Fellowship:

    • Neuroimmunology, Thomas Jefferson University, Philadelphia, PA. 2006-2008

Publications

  • "The radiologically isolated syndrome" Current Neurology and Neuroscience Reports October 2011
  • "Body-worn sensors capture variability, but not decline, of gait and balance measures in multiple sclerosis over 18 months" Gait and Posture  2014
  • "Body-worn motion sensors detect balance and gait deficits in people with multiple sclerosis who have normal walking speed" Gait and Posture April 2012
  • "Inflammatory neurological disease in patients treated with tumor necrosis factor alpha inhibitors" Multiple Sclerosis  2011
  • "Postural response latencies are related to balance control during standing and walking in patients with multiple sclerosis" Archives of Physical Medicine and Rehabilitation  2014
  • "Magnetic resonance imaging correlates of clinical outcomes in early multiple sclerosis" Multiple Sclerosis and Related Disorders  2014
  • "When metals compete" Nature Reviews Neurology  2009
  • "Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis" British Journal of Ophthalmology October 1 2014
  • "Thickness of retinal nerve fiber layer correlates with disease duration in parallel with corticospinal tract dysfunction in untreated multiple sclerosis" Journal of rehabilitation R&D  2009
  • "Mind-body medicine for multiple sclerosis" Autoimmune Diseases  2012
  • "Retinal axonal loss in very early stages of multiple sclerosis" European Journal of Neurology July 1 2015
  • "Recent developments in multiple sclerosis therapeutics" BMC Medicine December 7 2009
  • "Longitudinal associations between brain structural changes and fatigue in early MS" Multiple Sclerosis and Related Disorders January 1 2016
  • "Longitudinal associations between MRI and cognitive changes in very early MS" Multiple Sclerosis and Related Disorders January 1 2016
  • "Characterization of Compensatory Stepping in People With Multiple Sclerosis" Archives of Physical Medicine and Rehabilitation  2016
  • "Subcortical grey matter volumes predict subsequent walking function in early multiple sclerosis" Journal of the Neurological Sciences July 15 2016
  • "Low-fat, plant-based diet in multiple sclerosis" Multiple Sclerosis and Related Disorders September 1 2016
  • "Nicolau syndrome and localized panniculitis" Journal of Cutaneous Pathology November 1 2016
  • "The contemporary spectrum of multiple sclerosis misdiagnosis" Neurology September 27 2016
  • "Lipoic acid in secondary progressive MS" Neurology: Neuroimmunology and NeuroInflammation  2017
  • "Lipoic acid pharmacokinetics at baseline and 1 year in secondary progressive MS" Neurology: Neuroimmunology and NeuroInflammation  2017
  • "A randomized controlled phase II trial of riluzole in early multiple sclerosis" Annals of Clinical and Translational Neurology May 1 2014
  • "Lipoic Acid Stimulates cAMP Production in Healthy Control and Secondary Progressive MS Subjects" Molecular Neurobiology November 15 2017
  • "Coherence analysis of trunk and leg acceleration reveals altered postural sway strategy during standing in persons with multiple sclerosis" Human Movement Science January 1 2017
  • "Effects of lipoic acid on migration of human B cells and monocyte-enriched peripheral blood mononuclear cells in relapsing remitting multiple sclerosis" Journal of Neuroimmunology February 15 2018
  • "Longitudinal optical coherence tomography study of optic atrophy in secondary progressive multiple sclerosis" Multiple Sclerosis November 1 2017
  • "Optical coherence tomography angiography enhances the detection of optic nerve damage in multiple sclerosis" British Journal of Ophthalmology April 1 2018
  • "Dietary supplements and other alternative substances for the treatment of multiple sclerosis"  April 19 2016
  • "Effects of lipoic acid on walking performance, gait, and balance in secondary progressive multiple sclerosis" Complementary Therapies in Medicine December 1 2018
  • "Myelin Oligodendrocyte Glycoprotein Antibody-Associated Demyelination Comorbid with Leber Hereditary Optic Neuropathy" JAMA Neurology January 1 2018

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