Photo of Philip J. S. Stork, M.D.

Philip J. S. Stork M.D.

  •      (503) 494-5494
    • Professor Vollum Institute
    • Senior Scientist Vollum Institute
    • Cancer Biology Graduate Program School of Medicine
    • Cell and Developmental Biology Graduate Program School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • OHSU Knight Cancer Institute School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Philip Stork earned his M.D. at Columbia University in 1984 and went on to a residency in Pathology at Harvard Medical School and a fellowship at Tufts-New England Medical Center. He became an assistant professor in the Department of Pathology at Tufts in 1988. Stork was appointed as an assistant scientist at the Vollum Institute in 1990, was promoted to scientist in 1997 and senior scientist in 2005. He holds a joint appointment in the Department of Cell, Developmental and Cancer Biology in OHSU's School of Medicine.

Dr. Stork and his colleagues use molecular and biochemical approaches to understand how hormones and growth factors convey signals from the outside of a cell to the nucleus to induce cellular responses. Over the past few years, the Stork laboratory has tried to understand a fundamental question in the field of signal transduction: how can qualitative changes in the magnitude and duration of a single signaling cascade lead to qualitative changes in the cellular response?

Areas of interest

  • small G proteins
  • MAP kinase
  • B-Raf

Education

  • B.S., Harvard University, Cambridge Massachusetts 1977
  • M.S., Stanford University, Stanford California 1978
  • M.D., Columbia University, New York New York 1984

Memberships and associations

  • Editorial Board, Molecular Cell Biology, 2008-2020

Publications

  • "β2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein Rap1 and the serine/threonine kinase B-Raf" Journal of Biological Chemistry August 18 2000
  • "Modulation of Rap activity by direct interaction of Gα(o) with rap1 GTPase-activating protein" Journal of Biological Chemistry July 30 1999
  • "Angiotensin II stimulates hyperplasia but not hypertrophy in immature ovine cardiomyocytes" Journal of Physiology May 1 2003
  • "Cloning and expression of two structurally distinct receptor-linked protein-tyrosine phosphatases generated by RNA processing from a single gene" Journal of Biological Chemistry September 15 1993
  • "The cyclic adenosine monophosphate-dependent protein kinase (PKA) is required for the sustained activation of mitogen-activated kinases and gene expression by nerve growth factor" Journal of Biological Chemistry April 3 1998
  • "Unexpected maturation of PI3K and MAPK-ERK signaling in fetal ovine cardiomyocytes" American Journal of Physiology - Renal Fluid and Electrolyte Physiology October 15 2014
  • "The requirement of specific membrane domains for Raf-1 phosphorylation and activation" Journal of Biological Chemistry January 31 2003
  • "Elevation of cyclic adenosine 3',5'-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells" Journal of Cancer Research January 1 1999
  • "[13] Receptor-activated tyrosine phosphatases" Methods in Neurosciences  1995
  • "Signaling pathways for PC12 cell differentiation" Science May 31 2002
  • "A Colorimetric Assay for Measuring Activation of Gs- and Gq-Coupled Signaling Pathways" Analytical Biochemistry April 1995
  • "Cyclic adenosine monophosphate can convert epidermal growth factor into a differentiating factor in neuronal cells" Journal of Biological Chemistry  1995
  • "Neuronal calcium activates a Rap1 and B-Raf signaling pathway via the cyclic adenosine monophosphate-dependent protein kinase" Journal of Biological Chemistry February 4 2000
  • "Hormonal control of insulin-like growth factor I gene transcription in human osteoblasts" Journal of Biological Chemistry August 17 2001
  • "CAMP signaling for ERK activation in neuronal cells" Folia Pharmacologica Japonica  2009
  • "Gα and Gβγ require distinct Src-dependent pathways to activate Rap1 and Ras" Journal of Biological Chemistry November 8 2002
  • "Ras-independent activation of ERK signaling via the Torso receptor tyrosine kinase is mediated by Rap1" Current Biology February 22 2005
  • "Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1" Molecular and Cellular Biology  2000
  • "The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells" Molecular Endocrinology October 1994
  • "A novel mitogen-activated protein kinase phosphatase" Journal of Biological Chemistry June 16 1995
  • "Allosteric activation of functionally asymmetric RAF kinase dimers" Cell August 29 2013
  • "Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes" Journal of Biological Chemistry August 27 1999
  • "Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation" Trends in Cell Biology June 1 2002
  • "Thyroid hormone drives fetal cardiomyocyte maturation" FASEB Journal January 2012
  • "cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway" Cell April 4 1997
  • "Extracellular signal-regulated kinase and phosphoinositol-3 kinase mediate IGF-1 induced proliferation of fetal sheep cardiomyocytes" American Journal of Physiology - Renal Fluid and Electrolyte Physiology December 2003
  • "B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells" International Immunology April 2013
  • "Somatostatin is targeted to the regulated secretory pathway of gonadotrophs in transgenic mice expressing a metallothionein-somatostatin gene" Journal of Biological Chemistry  1986
  • "CD28 and the tyrosine kinase Lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1" Molecular and Cellular Biology  2000
  • "Somatostatin is targeted to gonadotrophic secretory granules in transgenic mice expressing a metallothionein-somatostatin fusion gene" Annals of the New York Academy of Sciences  1987

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