Pepper J. Schedin, Ph.D.

  • Professor of Cell, Developmental and Cancer Biology, School of Medicine
  • Co-leader, Cancer Prevention and Control Program, OHSU Knight Cancer Institute, School of Medicine
  • Cell and Developmental Biology Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine
  • Cancer Biology Graduate Program, School of Medicine

Biography

The focus of the Schedin Lab research program is on understanding how normal breast development contributes to breast cancer risk and patient outcomes. We focus on the unique windows of breast development that occur during puberty, pregnancy and peri-menopause, as these developmental windows associate with high risk for breast cancer development and progression. Because tissue remodeling is the hallmark of these risk windows, our lab focuses on mammary epithelial-stromal interactions and how these interactions are modulated by physiology and life choices. My lab is at the forefront of investigating the normal mammary gland tissue environment and has shown that extracellular matrix proteins and immune cells are highly malleable, remodeling in response to puberty, pregnancy, menopause and even dietary intake. This stromal ‘plasticity’ contributes significantly to breast cancer risk, but also identifies unique developmental windows that can be targeted for the prevention and treatment of breast cancer. Current areas of research focus include understanding how pregnancy or menopause/diet interactions increase risk for breast cancer progression. From a prevention perspective, the strength in this ‘window of risk’ approach lies in the ability to limit duration of treatment, thus reducing treatment-related side effects associated with current breast cancer chemoprevention strategies. From a treatment perspective, our work identifies novel stromal markers, as well as potential drivers of breast cancers diagnosed in specific ‘developmental windows’ such as pregnancy and menopause, which can be exploited for targeted drug development. For our studies we utilize the rat MNU model, breast cancer xenograft, transgenic, and immunocompetent mouse models, 3D multi-cell co-culture systems, and human breast tissue. Our systems approach has yielded promising results for prevention and treatment of pregnancy-associated breast cancer and obesity-induced postmenopausal breast cancer.

Education

  • Ph.D., 1988, University of Colorado

Memberships and associations

  • American Association for Cancer Research Women in Cancer Research
  • Metastasis Research Society

Areas of interest

  • young women's breast cancer,
  • breast cancer prevention
  • metastasis
  • tumor micro-environment
  • immune suppression, extracellular matrix, fibrosis, ECM proteomics
  • 3D cell culture modeling

Publications

Publications

  • {{ pub.journalAssociation.journal.names[0].value }}