Photo of Paul T. Spellman, Ph.D.

Paul T. Spellman Ph.D.

    • Professor of Molecular and Medical Genetics School of Medicine
    • Co-Director, CEDAR OHSU Knight Cancer Institute School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine
    • M.D./Ph.D. Program Committee School of Medicine

Paul Spellman, Ph.D., is a professor in the Department of Molecular and Medical Genetics in the OHSU School of Medicine and co-leader of the Quantitative Oncology Program in the OHSU Knight Cancer Institute. He uses genetic and genomic approaches to understand the processes by which cancer develops, monitor disease, and to identify therapeutic strategies. He focuses on using population genetics to help determine who is at risk for cancer, how to computationally analyze genomic data to identify early changes in cancers, and how to accurately screen different populations for the disease. He also works to inform the public about the ways that genetics shape cancer risk. Spellman received his Ph.D. in genetics from Stanford University.

Areas of interest

  • Genetics
  • Geonomics

Honors and awards

  • Penny and Phil Knight Professorship in Cancer Research Innovation

Memberships and associations

  • OHSU Center for Spatial Systems Biomedicine

Publications

  • "Final words" Trends in Biotechnology June 2004
  • "Erratum" Nature Medicine July 7 2015
  • "A guide to microarray experiments - An open letter to the scientific journals [1]" The Lancet September 28 2002
  • "Morphometic analysis of TCGA glioblastoma multiforme" BMC Bioinformatics December 20 2011
  • "Submission of microarray data to public repositories" PLoS Biology September 2004
  • "Integrated analysis of breast cancer cell lines reveals unique signaling pathways" Genome Biology March 25 2009
  • "Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination" Proceedings of the National Academy of Sciences of the United States of America September 1 2015
  • "The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila" Genes to Cells April 2006
  • "Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species" Proceedings of the National Academy of Sciences of the United States of America August 9 2005
  • "The Functional Genomics Experiment model (FuGE)" Biotechnology October 2007
  • "Integrated analysis of germline and somatic variants in ovarian cancer" Nature Communications January 22 2014
  • "Analysis of molecular inversion probe performance for allele copy number determination" Genome Biology November 20 2007
  • "Ceramic capillaries for use in microarray fabrication" PCR Methods and Applications  2001
  • "High-throughput method for analyzing methylation of CpGs in targeted genomic regions" Proceedings of the National Academy of Sciences of the United States of America July 13 2010
  • "Systematic variation in gene expression patterns in human cancer cell lines" Nature Genetics March 2000
  • "GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer" Nature Genetics April 2013
  • "Understanding and Using Information about Cancer Genomes"  March 2014
  • "A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047" BMC Medicine December 14 2009
  • "The future of publishing microarray data." Briefings in Bioinformatics December 2001
  • "Prognostically relevant gene signatures of high-grade serous ovarian carcinoma" Journal of Clinical Investigation January 2 2013
  • "A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes" Cancer Cell December 2006
  • "Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts" Neuro-Oncology October 2009
  • "Temporal dissection of tumorigenesis in primary cancers" Cancer Discovery June 29 2011
  • "Cancer Genomics"   2008
  • "The cancer genome atlas pan-cancer analysis project" Nature Genetics October 2013
  • "Learning invariant features of tumor signatures"   2012
  • "Stacked Predictive Sparse Decomposition for Classification of Histology Sections" International Journal of Computer Vision May 1 2015
  • "Integrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian carcinoma" PLoS One March 29 2012
  • "Predictive sparse morphometric context for classification of histology sections"  July 21 2015
  • "Phospholipid Scramblase 1, an interferon-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells" Molecular Cancer April 26 2013

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