Photo of Paul Brehm, Ph.D.

Paul Brehm Ph.D.

Paul Brehm received his degree in zoology from the University of Wisconsin before entering the PhD program at UCLA where he trained with James Morin in marine biology and bioluminescence. Postgraduate training with Roger Eckert at UCLA and Yoshi Kidokoro at The Salk Institute focused on calcium channels and synaptic transmission. The next 10 years were spent as an associate professor in the Department of Physiology at Tufts Medical School in Boston and summers at the Marine Biological Laboratory at Woods Hole. In 1990 Brehm moved to Stony Brook University in New York where he served as professor of Neurobiology and Behavior before assuming a position as senior scientist at the Vollum in 2007.

Dr. Brehm's lab is currently focused on several projects involving ion channels and synaptic transmission in vertebrate animal models.

Areas of interest

  • zebrafish genetics
  • electrophysiology
  • ion channel function
  • imaging


  • B.S., University of Wisconsin, Madison 1970
  • Ph.D., University of California, Los Angeles 1975

Honors and awards

  • AAAS Fellow
  • Jacob J. Javits Neuroscience Investigator, NIH, NINDS
  • Eureka Awardee, NIH, NINDS
  • McKnight Technology Awardee
  • Muscular Dystrophy Association Fellow
  • NIH Director's Award


  • "Erratum" Neuron  1998
  • "Adult forms of nicotinic acetylcholine receptors are expressed in the absence of nerve during differentiation of a mouse skeletal muscle cell line" Developmental Biology  1994
  • "Calcium entry leads to inactivation of calcium channel in Paramecium" Science  1978
  • "Calcium channel isoforms underlying synaptic transmission at embryonic Xenopus neuromuscular junctions" Journal of Neuroscience January 15 2001
  • "Optical Measurements of Presynaptic Release in Mutant Zebrafish Lacking Postsynaptic Receptors" Journal of Neuroscience November 19 2003
  • "Calcium-mediated inactivation of calcium current in Paramecium" Journal of Physiology  1980
  • "Channel open time of acetylcholine receptors on Xenopus muscle cells in dissociated cell culture" Developmental Biology  1982
  • "Synaptic homeostasis in a zebrafish glial glycine transporter mutant" Journal of Neurophysiology October 2008
  • "Persistent electrical coupling and locomotory dysfunction in the zebrafish mutant shocked" Journal of Neurophysiology October 2004
  • "Electrophysiology and luminescence of an ophiuroid radial nerve." Journal of Experimental Biology December 1977
  • "A single site on the ε{lunate} subunit is responsible for the change in ACh receptor channel conductance during skeletal muscle development" Neuron  1995
  • "A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction" Neuron  1995
  • "A single site on the epsilon subunit is responsible for the change in ACh receptor channel conductance during skeletal muscle development." Neuron May 1998
  • "The epsilon subunit confers fast channel gating on multiple classes of acetylcholine receptors" Journal of Neuroscience  1993
  • "An electrically coupled network of skeletal muscle in zebrafish distributes synaptic current" Journal of General Physiology  2006
  • "Intercellular signaling as visualized by endogenous calcium-dependent bioluminescence" Neuron  1989
  • "Function of neuromuscular synapses in the zebrafish choline- acetyltransferase mutant bajan" Journal of Neurophysiology October 2008
  • "Paralytic zebrafish lacking acetylcholine receptors fail to localize rapsyn clusters to the synapse" Journal of Neuroscience August 1 2001
  • "Synchronous and asynchronous modes of synaptic transmission utilize different calcium sources" eLife December 24 2013
  • "Contributions of the gamma and epsilon subunit family to nicotinic acetylcholine receptor function." Receptors and Channels  1993
  • "Ion channel evolution" Seminars in the Neurosciences  1991
  • "Two subcellular mechanisms underlie calcium-dependent facilitation of bioluminescence" Neuron  1994
  • "Zebrafish model for congenital myasthenic syndrome reveals mechanisms causal to developmental recovery" Proceedings of the National Academy of Sciences of the United States of America October 23 2012
  • "Modal shifts in acetylcholine receptor channel gating confer subunit-dependent desensitization" Science June 18 1993
  • "Progesterone treatment abolishes exogenously expressed ionic currents in Xenopus oocytes" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  2001
  • "Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor" Molecular Endocrinology  1990
  • "An acetylcholine receptor lacking both γ and ε subunits mediates transmission in zebrafish slow muscle synapses" Journal of General Physiology September 2011
  • "Zebrafish calls for reinterpretation for the roles of P/Q calcium channels in neuromuscular transmission" Journal of Neuroscience April 24 2013
  • "Zebrafish CaV2.1 Calcium Channels Are Tailored for Fast Synchronous Neuromuscular Transmission" Biophysical Journal February 3 2015

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