Photo of Ov D. Slayden, Ph.D.

Ov D. Slayden Ph.D.

  • (503) 346-5435
    • Professor Oregon National Primate Research Center
    • Professor of Obstetrics and Gynecology School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Ov D. Slayden, Ph.D. is a Professor in the Division of Developmental and Reproductive Sciences at the Oregon National Primate Research Center and has joint appointments in the Department of Obstetrics and Gynecology and in Physiology and Pharmacology, School of Medicine, OHSU. Dr. Slayden received his B.A. and M.A. degrees in Biology from Sonoma State University, and earned a Ph.D. in Biochemistry and Animal Science at Oregon State University. Dr. Slayden moved to the Center in 1991 after being awarded a Reproductive Biology Training Fellowship through the Department of Physiology at OHSU.

The Slayden Laboratory conducts research relating to contraception and reproductive tract disorders including irregular menstrual bleeding, menorrhagia, endometriosis, and polycystic ovarian syndrome (PCOS). The Slayden Laboratory is 100% invested in studies on nonhuman primates (NHPs) including macaques and baboons. Our work bridges the gap between bench research and clinical trials in women. Techniques employed include: in vivo experiments in monkeys, in vivo studies with endometriosis xenograft models, NHP cell culture, histology, immunohistochemistry, in situ hybridization, laser capture microdissection, and quantitative real-time PCR. We also apply advanced imaging techniques including contrast-enhanced ultrasound, and dynamic contrast MRI. Our broad premise is that a better understanding of disorders that underlie irregular and excessive menstrual bleeding in NHPs can be leveraged to improve reproductive health of women. An ongoing focus of my lab has been to understand better the effect of low dose progestin-based contraceptives in order to identify and develop novel non-hormonal contraceptive technologies. Initially supported by a U54 Contraceptive Center Grant (HD 055744-01), our efforts are now focused on the cervix as a target for non-hormonal contraceptives.  In addition to NIH supported studies, many of our contraception-based studies have been supported by pharmaceutical contracts.  I am Co-Principal Investigator on studies leading to nonsurgical permanent contraception in the Oregon Center for Research on Permanent Contraception (OPERM). Beyond our work on contraception, the Slayden laboratory manages the NHP Core for our National Center for Translational Research in Reproduction and Infertility (NCTRI) Center (P50 HD071836). The broad goal of our NCTRI Center is to evaluate the role of hyper-androgenemia and a high fat diet on Female Reproductive Health. Elevated levels of testosterone, and an obesogenic “Western Style” diet are correlated presentation of PCOS in many women. In addition, Dr. Slayden oversees an independent project funded by the NCTRI (Project III) that evaluates the effect of testosterone and diet on uterine and placental function. Irregular uterine bleeding is often an unwanted outcome of progestin-only contraception. While much of our efforts have addressed contraception and fertility, we are keenly focused on understanding menstrual disorders and the relationship of heavy uterine bleeding and the etiology of endometriosis in NHPs. We have experience in the etiology of endometriosis in monkeys and have developed a model for inducing endometriosis in disease-free animals to assess pathophysiological events during lesion establishment. We are currently collaborating on studies to evaluate new technologies to image and ablate endometriotic lesions during gynecologic surgery.

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Areas of interest

  • Endometriosis
  • Contraception
  • PCOS
  • Hormonal Regulation of the Reproductive Tract

Education

  • B.A., Sonoma State University, Rohnert Park California 1979
  • B.A., Sonoma State University 1979
  • M.A., Sonoma State University 1984
  • M.A., Sonoma State University, Rohnert Park California 1984
  • Ph.D., Oregon State University 1991
  • Ph.D., Oregon State University, Corvallis Oregon 1991
  • Fellowship:

    • Postdoctoral Fellowship, Oregon National Primate Research Center, OHSU, 1992

Honors and awards

  • 2007 Technology Innovation Award, Oregon Health & Science University: A Top 10 Sponsored Research Awardee
  • 2008 -2010 Technology Innovation Award, Oregon Health & Science University: A Top Five Sponsored Research Awardee
  • 2011, 2013-16 Technology Innovation Award, Oregon Health & Science University: A Top Sponsored Research Awardee
  • 2017-2019 ASRM Star Award; Recognition for at least nine out of ten successive years presenting at ASRM Scientific Congresses

Memberships and associations

  • American Association for Advancement of Science
  • American Association for Cell Biology
  • American Society for Reproductive Medicine
  • American Society of Mammalogists
  • Endocrine Society
  • Sigma Xi, Oregon State University Chapter
  • Society for Gynecologic Investigation
  • Society for the Study of Reproduction

Publications

  • "Premenstrual and menstrual changes in the macaque and human endometrium" Annals of the New York Academy of Sciences  2002
  • "In vitro and in vivo characterization of a novel nonsteroidal, species-specific progesterone receptor modulator, PRA-910."   2007
  • "The rhesus macaque as an animal model for pelvic organ prolapse" American Journal of Obstetrics and Gynecology  2002
  • "In vivo and in vitro effects of a cyclopropenoid fatty acid on ovine corpus luteum function" Endocrinology December 1990
  • "Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)" Reproductive Biology and Endocrinology October 9 2006
  • "A role for the androgen receptor in the endometrial antiproliferative effects of progesterone antagonists" Steroids November 2003
  • "Progesterone suppresses an oxytocin-stimulated signal pathway in COS-7 cells transfected with the oxytocin receptor" Steroids December 22 2008
  • "Blockade of tubal patency following transcervical administration of polidocanol foam" Contraception  2014
  • "Effects of keratinocyte growth factor in the endometrium of rhesus macaques during the luteal-follicular transition" Journal of Clinical Endocrinology and Metabolism  2000
  • "Anti-proliferative effects of progesterone antagonists in the primate endometrium" Reproduction  2002
  • "Assessment of progestin-only therapy for endometriosis in macaque" Journal of Medical Primatology February 2008
  • "Gonadotrophic and local control of the developing corpus luteum in rhesus monkeys" Human Reproduction  1993
  • "Radioligand binding assay of progesterone receptors in the primate corpus luteum after in vivo treatment with the 3β-hydroxysteroid dehydrogenase inhibitor, trilostane" Journal of Clinical Endocrinology and Metabolism August 1994
  • "Progesterone receptor antagonists and the endometrial antiproliferative effect" Seminars in Reproductive Medicine February 2005
  • "A chronic, low-dose regimen of the antiprogestin ZK 137 316 prevents pregnancy in rhesus monkeys" Human Reproduction  1998
  • "A critical period of progesterone withdrawal precedes menstruation in macaques" Reproductive Biology and Endocrinology October 9 2006
  • "Progesterone antagonists increase androgen receptor expression in the rhesus macaque and human endometrium" Journal of Clinical Endocrinology and Metabolism  2001
  • "Novel progesterone receptor modulators" Bioorganic and Medicinal Chemistry Letters December 1 2012
  • "Evidence for a potential role of neuropeptide Y in ovine corpus luteum function" Domestic Animal Endocrinology February 2010
  • "Action of a cyclopropenoid fatty acid on the corpus luteum of pregnant and nonpregnant ewes" Biology of Reproduction  1994
  • "Endometrial CXCL13 expression is cycle regulated in humans and aberrantly expressed in humans and rhesus macaques with endometriosis" Reproductive Sciences April 15 2015
  • "Suppressive action of gonadotropin-releasing hormone and luteinizing hormone on function of the developing ovine corpus luteum." Journal of Animal Science August 1990
  • "Progesterone-induced gene expression in uterine epithelia" Biology of Reproduction November 2008
  • "Induced endometriosis in nonhuman primates" Biology of Reproduction February 2013
  • "The role of scientists and clinicians in raising public support for animal research in reproductive biology and medicine" Biology of Reproduction February 2013
  • "Matrix metalloproteinase expression in Macaca mulatta endometrium" Biology of Reproduction December 1998
  • "Cyclic remodeling of the nonhuman primate endometrium" Seminars in Reproductive Medicine  2014
  • "Reversible suppression of menstruation with progesterone antagonists in rhesus macaques" Human Reproduction  2001
  • "Immunocytochemical localization of androgen receptors in brains of developing and adult male rhesus monkeys" Endocrine  1998
  • "Erratum" Journal of Medical Primatology August 2008

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