Ov D. Slayden, Ph.D.

  • Professor, Oregon National Primate Research Center
  • Professor of Obstetrics and Gynecology, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Biography

Ov D. Slayden, Ph.D. is a Professor in the Division of Developmental and Reproductive Sciences at the Oregon National Primate Research Center and has joint appointments in the Department of Obstetrics and Gynecology and in Physiology and Pharmacology, School of Medicine, OHSU. Dr. Slayden received his B.A. and M.A. degrees in Biology from Sonoma State University, and earned a Ph.D. in Biochemistry and Animal Science at Oregon State University. Dr. Slayden moved to the Center in 1991 after being awarded a Reproductive Biology Training Fellowship through the Department of Physiology at OHSU.

The Slayden Laboratory conducts research relating to contraception and reproductive tract disorders including irregular menstrual bleeding, menorrhagia, endometriosis, and polycystic ovarian syndrome (PCOS). The Slayden Laboratory is 100% invested in studies on nonhuman primates (NHPs) including macaques and baboons. Our work bridges the gap between bench research and clinical trials in women. Techniques employed include: in vivo experiments in monkeys, in vivo studies with endometriosis xenograft models, NHP cell culture, histology, immunohistochemistry, in situ hybridization, laser capture microdissection, and quantitative real-time PCR. We also apply advanced imaging techniques including contrast-enhanced ultrasound, and dynamic contrast MRI. Our broad premise is that a better understanding of disorders that underlie irregular and excessive menstrual bleeding in NHPs can be leveraged to improve reproductive health of women. An ongoing focus of my lab has been to understand better the effect of low dose progestin-based contraceptives in order to identify and develop novel non-hormonal contraceptive technologies. Initially supported by a U54 Contraceptive Center Grant (HD 055744-01), our efforts are now focused on the cervix as a target for non-hormonal contraceptives.  In addition to NIH supported studies, many of our contraception-based studies have been supported by pharmaceutical contracts.  I am Co-Principal Investigator on studies leading to nonsurgical permanent contraception in the Oregon Center for Research on Permanent Contraception (OPERM). Beyond our work on contraception, the Slayden laboratory manages the NHP Core for our National Center for Translational Research in Reproduction and Infertility (NCTRI) Center (P50 HD071836). The broad goal of our NCTRI Center is to evaluate the role of hyper-androgenemia and a high fat diet on Female Reproductive Health. Elevated levels of testosterone, and an obesogenic “Western Style” diet are correlated presentation of PCOS in many women. In addition, Dr. Slayden oversees an independent project funded by the NCTRI (Project III) that evaluates the effect of testosterone and diet on uterine and placental function. Irregular uterine bleeding is often an unwanted outcome of progestin-only contraception. While much of our efforts have addressed contraception and fertility, we are keenly focused on understanding menstrual disorders and the relationship of heavy uterine bleeding and the etiology of endometriosis in NHPs. We have experience in the etiology of endometriosis in monkeys and have developed a model for inducing endometriosis in disease-free animals to assess pathophysiological events during lesion establishment. We are currently collaborating on studies to evaluate new technologies to image and ablate endometriotic lesions during gynecologic surgery.

Education

  • B.A., 1979, Sonoma State University
  • B.A., 1979, Sonoma State University
  • M.A., 1984, Sonoma State University
  • M.A., 1984, Sonoma State University
  • Ph.D., 1991, Oregon State University
  • Ph.D., 1991, Oregon State University
  • Fellowship:

    • Postdoctoral Fellowship, Oregon National Primate Research Center, OHSU, 1992

Honors and awards

  • 2007 Technology Innovation Award, Oregon Health & Science University: A Top 10 Sponsored Research Awardee
  • 2008 -2010 Technology Innovation Award, Oregon Health & Science University: A Top Five Sponsored Research Awardee
  • 2011, 2013-16 Technology Innovation Award, Oregon Health & Science University: A Top Sponsored Research Awardee
  • 2017-2019 ASRM Star Award; Recognition for at least nine out of ten successive years presenting at ASRM Scientific Congresses

Memberships and associations

  • American Association for Advancement of Science
  • American Association for Cell Biology
  • American Society for Reproductive Medicine
  • American Society of Mammalogists
  • Endocrine Society
  • Sigma Xi, Oregon State University Chapter
  • Society for Gynecologic Investigation
  • Society for the Study of Reproduction

Areas of interest

  • Endometriosis
  • Contraception
  • PCOS
  • Hormonal Regulation of the Reproductive Tract

Publications

Publications

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