Headshot photo of Ov D. Slayden, Ph.D.

Ov D. Slayden, Ph.D.

  • Professor, Oregon National Primate Research Center
  • Adjunct Professor of Obstetrics and Gynecology, School of Medicine

Biography

Ov D. Slayden, Ph.D. is a Professor in the Division of Developmental and Reproductive Sciences at the Oregon National Primate Research Center and has a joint appointment in the Department of Obstetrics and Gynecology, OHSU. Dr. Slayden received his B.A. and M.A. degrees in Biology from Sonoma State University and earned a Ph.D. in Biochemistry and Animal Science at Oregon State University. Dr. Slayden moved to the Primate Center in 1991 after receiving a Reproductive Biology Training Fellowship through the Department of Physiology at OHSU.

Dr. Slayden conducts research on contraception and reproductive tract disorders, including irregular menstrual bleeding, endometriosis, and polycystic ovarian syndrome (PCOS). His laboratory is 100% invested in studies on nonhuman primates (NHPs), including macaques and baboons. Their broad premise is that a better understanding of disorders that underlie NHP reproductive tract physiology can be leveraged to improve overall reproductive health for women. Their studies bridge the gap between bench research and clinical trials in women and are supported by a combination of NIH, foundation, and pharmaceutical grants. These grants involve identifying and developing novel hormonal and non-hormonal contraception, assessing and treating heavy menstrual bleeding, and novel therapies to image and ablate endometriotic lesions. Techniques employed by the laboratory include: in vivo experiments in NHPs, NHP cell culture, histology, immunohistochemistry, laser capture microdissection, and quantitative real-time PCR.   They also perform non-invasive imaging, including contrast-enhanced ultrasound, PET imaging, and dynamic contrast MRI on NHPs.

Education and training

    • B.A., 1979, Sonoma State University
    • M.A., 1984, Sonoma State University
    • Ph.D., 1991, Oregon State University
  • Fellowship

    • Postdoctoral Fellowship, Oregon National Primate Research Center, OHSU, 1992

Memberships and associations:

  • American Association for Advancement of Science
  • American Association for Cell Biology
  • American Society for Reproductive Medicine
  • American Society of Mammalogists
  • Endocrine Society
  • Sigma Xi, Oregon State University Chapter
  • Society for the Study of Reproductive Investigation
  • Society for the Study of Reproduction
  • World Endometriosis Society

Areas of interest

  • Endometriosis
  • Contraception
  • PCOS
  • Menstrual Bleeding
  • Hormonal Regulation of the Reproductive Tract

Honors and awards

  • 2007 Technology Innovation Award, Oregon Health & Science University: A Top 10 Sponsored Research Awardee
  • 2008 -2010 Technology Innovation Award, Oregon Health & Science University: A Top Five Sponsored Research Awardee
  • 2011, 2013-16 Technology Innovation Award, Oregon Health & Science University: A Top Sponsored Research Awardee
  • 2017-2022 ASRM Star Award; Recognition for at least nine out of ten successive years presenting at ASRM Scientific Congresses

Publications

Selected publications

  • Bishop CV, Takahashi DL, Luo F, Sidener H, Martin LD, Gao L, Fei SS, Hennebold JD, Slayden OD.  The combined impact of testosterone and Western-style diet on endometriosis severity and progression in rhesus macaques†.  Biol Reprod. 2023 Jan 14;108(1):72-80. doi: 10.1093/biolre/ioac183. PMID: 36173894
  • Park Y, Demessie AA, Luo A, Taratula OR, Moses AS, Do P, Campos L, Jahangiri Y, Wyatt CR, Albarqi HA, Farsad K, Slayden OD, Taratula O.  Targeted Nanoparticles with High Heating Efficiency for the Treatment of Endometriosis with Systemically Delivered Magnetic Hyperthermia.   Small. 2022 Jun;18(24):e2107808. doi: 10.1002/smll.202107808.  Epub 2022 Apr 17. PMID: 35434932
  • Slayden OD, Luo F, Bishop CV. Physiological Action of Progesterone in the Nonhuman Primate Oviduct.  Cells. 2022 May 3;11(9):1534. doi: 10.3390/cells11091534. PMID: 35563839.
  • Moses AS, Demessie AA, Taratula O, Korzun T, Slayden OD, Taratula O. Nanomedicines for Endometriosis: Lessons Learned from Cancer Research. Small. 2021 Jan 25:e2004975. doi: 10.1002/smll.202004975. Epub ahead of print. PMID: 33491876.
  • Bishop CV, Takahashi D, Mishler E, Slayden OD, Roberts CT, Hennebold J, True C. Individual and combined effects of 5-year exposure to hyperandrogenemia and Western-style diet on metabolism and reproduction in female rhesus macaques. Hum Reprod. 2021 Jan 25;36(2):444-454. doi:10.1093/humrep/deaa321. PMID: 33313720; PMCID: PMC7829549.
  • Slayden OD, Friason FKE, Bond KR, Mishler EC. Hormonal regulation of oviductal glycoprotein 1 (OVGP1; MUC9) in the rhesus macaque cervix. J Med Primatol. 2018 Dec;47(6):362-370. doi: 10.1111/jmp.12357. Epub 2018 Jul 4. PMID: 29971796; PMCID: PMC6234059.
  • Bishop CV, Stouffer RL, Takahashi DL, Mishler EC, Wilcox MC, Slayden OD, True CA. Chronic hyperandrogenemia and western-style diet beginning at puberty reduces fertility and increases metabolic dysfunction during pregnancy in young adult, female macaques. Hum Reprod. 2018 Apr 1;33(4):694-705. doi: 10.1093/humrep/dey013. PMID: 29401269; PMCID: PMC6454458.
  • Bishop CV, Mishler EC, Takahashi DL, Reiter TE, Bond KR, True CA, Slayden OD, Stouffer RL. Chronic hyperandrogenemia in the presence and absence of a western-style diet impairs ovarian and uterine structure/function in young adult rhesus monkeys. Hum Reprod. 2018 Jan 1;33(1):128-139. doi: 10.1093/humrep/dex338. PMID: 29190387; PMCID: PMC5850861.
  • Jensen JT, Hanna C, Mishler E, Lim JY, Slayden OD. Effect of menstrual cycle phase and hormonal treatments on evaluation of tubal patency in baboons. J Med Primatol. 2018 Feb;47(1):40-45. doi: 10.1111/jmp.12317. Epub 2017 Oct 24. PMID: 29063622; PMCID: PMC5771854.
  • True CA, Takahashi DL, Burns SE, Mishler EC, Bond KR, Wilcox MC, Calhoun AR, Bader LA, Dean TA, Ryan ND, Slayden OD, Cameron JL, Stouffer RL. Chronic combined hyperandrogenemia and westernstyle diet in young female rhesus macaques causes greater metabolic impairments compared to either treatment alone. Hum Reprod. 2017 Sep 1;32(9):1880-1891. doi: 10.1093/humrep/dex246. PMID: 28854721; PMCID: PMC5850848.

Publications

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