Photo of Nabil J. Alkayed, M.D., Ph.D

Nabil J. Alkayed M.D., Ph.D

    • Professor of Anesthesiology and Perioperative Medicine School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. Alkayed is Professor and Vice Chair for Research of Anesthesiology and PeriOperative Medicine (APOM) at Oregon Health & Science University (OHSU) and holds a joint appointment in Physiology and Pharmacology. He is Director of the newly formed Division of Cerebrovascular Research and Associate Director of the Research Center for Gender-Based Medicine at OHSU. In addition, Dr. Alkayed serves on the Program for Molecular and Cellular Biosciences (PMCB) and the Neuroscience Graduate Program (NGP) at OHSU.Dr. Alkayed is funded through two R01 grants from the National Institute of Neurological Disease and Stroke (NINDS) to study the role of sEH in ischemic brain injury and vascular dysfunction after stroke n postmenopausal females. In addition, he has a grant from the Oregon Alzheimer Disease Center to study the role of sEH in aging-related white matter lesions. Dr. Alkayed sits on the editorial boards of Stroke, The American Journal of Physiology–Heart and Circulation, and the Journal of Cerebral Blood Flow and Metabolism. He is a member of the American Heart Association Brain and Stroke Study Section and the National Institutes of Health Neural Oxidative Metabolism and Death Study Section. Dr. Alkayed grew up in Amman, Jordan. He earned his medical degree from Stavropol State Medical Academy in Russia and a PhD in physiology from the Medical College of Wisconsin in Milwaukee. After completing a postdoctoral research fellowship at Johns Hopkins University, Dr. Alkayed launched his academic career as Assistant Professor of Anesthesiology & Critical Care Medicine at The Johns Hopkins School of Medicine in 1998. He joined OHSU in 2003 as Associate Professor, was promoted to Professor in 2008, and to Vice Chair for Research in 2011.

Education

  • M.D., Stavropol State Medical Academy, Stavropol 1986
  • Ph.D., Medical College of Wisconsin, Milwaukee Wisconsin 1996
  • Fellowship:

    • Postdoctoral Fellowship in Cerebral Ischemia, Johns Hopkins University, Baltimore, MD, 1996-1998

Memberships and associations

  • American Physiological Society Society for NeuroscienceFellow of the American Heart Association Stroke CouncilInternational Soceity of Cerebral Blood Flow and MetabolismAssociation of University Anesthesiologists

Publications

  • "Estrogen receptor antagonist ICI182,780 exacerbates ischemic injury in female mouse" Journal of Cerebral Blood Flow and Metabolism  2000
  • "In vivo optical imaging of revascularization after brain trauma in mice" Microvascular Research January 2011
  • "Recombinant T Cell Receptor Ligand Treatment Improves Neurological Outcome in the Presence of Tissue Plasminogen Activator in Experimental Ischemic Stroke" Translational Stroke Research  2014
  • "Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia" Journal of Cerebral Blood Flow and Metabolism August 2009
  • "Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors" American Journal of Physiology - Renal Fluid and Electrolyte Physiology November 1 2002
  • "Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels" American Journal of Physiology - Renal Fluid and Electrolyte Physiology May 2009
  • "Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice" FASEB Journal  2010
  • "Guanine nucleotide-binding proteins in aortic smooth muscle from hypertensive rats" Hypertension  1994
  • "Synthesis of 14,15-EET from Arachidonic Acid Using Urea-Hydrogen Peroxide as the Oxidant" Synthetic Communications January 2 2015
  • "Epoxyeicosanoid signaling in CNS function and disease" Prostaglandins and Other Lipid Mediators April 2010
  • "Protective Role of P450 Epoxyeicosanoids in Subarachnoid Hemorrhage" Neurocritical Care  2015
  • "Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABA" Journal of Cerebral Blood Flow and Metabolism April 2006
  • "Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke" Stroke  2001
  • "Epoxyeicosatrienoic acids are endogenous regulators of vasoactive neuropeptide release from trigeminal ganglion neurons" Journal of Neurochemistry December 2010
  • "Estrogen inhibits Fas-mediated apoptosis in experimental stroke" Journal of Cerebral Blood Flow and Metabolism November 13 2007
  • "Neuroprotective effects of female gonadal steroids in reproductively senescent female rats" Stroke January 2000
  • "Heme oxygenase-2 is neuroprotective in cerebral ischemia" Molecular Medicine  1999
  • "In vivo cerebrovascular effects of cocaine- and amphetamine-regulated transcript (CART) peptide" Journal of Cardiovascular Pharmacology July 2008
  • "Functional hyperemia in the brain" Stroke January 1998
  • "Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection" Proceedings of the National Academy of Sciences of the United States of America September 26 2006
  • "Coronary autoregulation is abnormal in syndrome X" Journal of the American Society of Echocardiography March 2013
  • "Characterization of a new double-filament model of focal cerebral ischemia in heme oxygenase-2-deficient mice" American Journal of Physiology - Renal Fluid and Electrolyte Physiology July 1 2003
  • "Epoxyeicosatrienoic acids mediate insulin-mediated augmentation in skeletal muscle perfusion and blood volume" American Journal of Physiology - Renal Fluid and Electrolyte Physiology December 15 2014
  • "Hydrogen sulfide protects against myocardial ischemia and reperfusion injury by activating AMP-activated protein kinase to restore autophagic flux" Biochemical and Biophysical Research Communications March 13 2015
  • "Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo" American Journal of Physiology - Renal Fluid and Electrolyte Physiology November 2008
  • "Cytochrome P450 in neurological disease" Current Drug Metabolism June 2004
  • "Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection" Journal of Neuroscience July 4 2007
  • "Neurobehavioral and Imaging Correlates of Hippocampal Atrophy in a Mouse Model of Vascular Cognitive Impairment" Translational Stroke Research June 5 2015
  • "Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke" Neuroscience February 2 2013
  • "Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury" Journal of Neuroscience April 25 2007

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