• Professor of Molecular and Medical Genetics, School of Medicine
  • Cancer Biology Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine


Dr. Dai’s research focuses on the understanding of the biological function and molecular mechanisms of the p53 tumor suppression and c-Myc oncogenic pathways. Dr. Dai’s prior research has demonstrated that some ribosomal proteins play a critical role in regulating both the MDM2-p53 and c-Myc pathway in response to nucleolar stress. His findings help to understand how ribosomal biogenesis is tightly coordinated with cell cycle progression during normal homeostasis. Currently, Dr. Dai’s lab is investigating (1) the mechanism underlying  post-translational regulation of the MDM2-p53 pathway, including ubiquitination and SUMOylation regulation of p53 protein stability and activity by in response to stress. (2) the role of ubiquitination and SUMOylation in controlling c-Myc protein stability and activity. (3) role and mechanisms of ubiquitination and SUMOylation  regulation of nucleolar factors in nucleolar dynamics and ribosome biogenesis in cancer.  Dr. Dai’s research would provide important information on how the p53 tumor suppressor and c-Myc oncoprotein are tightly controlled in both physiological and stress conditions, thereby providing a possible means to manipulate p53 and c-Myc function in cancer cells.

Education and training

    • M.D., 1988, Anhui Medical University
    • M.Sc., 1994, Sun Yat-Set University School of Medicine
    • Ph.D., 2005, Oregon Health & Science University


Elsevier pure profile

Selected publications

  • Hyunju Ryu, Xiao-Xin Sun, Yingxiao Chen, Yanping Li, Xiaoyan Wang, Roselyn S. Dai, Hong-Ming Zhu, John Klimek, Larry David, Lev M. Fedorov, Yoshiaki Azuma, Rosalie C. Sears, Mu-Shui Dai. (2021) The deubiquitinase USP36 promotes snoRNP group SUMOylation and is essential for ribosome biogenesis. EMBO Rep, 22(6): e50684
  • Krishna Mohan Chauhan, Yingxiao Chen, Yiyi Chen, Andrew T. Liu, Xiao-Xin Sun, Mu-Shui Dai. (2021) SENP1 deSUMOylates p53 and regulates its activity. J Cell Biochem, 122(2): 189-197
  •  Xiao-Xin Sun, Yingxiao Chen, Krishna Mohan Chauhan, Juan Liang, Xiaoyan Wang, Collin J. Daniel, Rosalie C. Sears, Mu-Shui Dai. (2018) SUMO protease SENP1 deSUMOylates and stabilizes c-Myc. Proc Natl Acad Sci USA, 115(43), 10983-10988
  • Xiao-Xin Sun, Xia He, Li Yin, Masayuki Komada, Rosalie C. Sears, Mu-Shui Dai. (2015)    The nucleolar deubiquitinating enzyme USP36 deubiquitinates and stabilizes c-Myc.  Proc Natl Acad Sci USA, 112(12): 3734-3739
  • Xiao-Xin Sun, Kishore B. Challagundla, Mu-Shui Dai. (2012) Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. EMBO J, 31(3): 576-592
  • Kishore B. Challagundla, Xiao-Xin Sun, Xiaoli Zhang, Tiffany DeVine, Qinghong Zhang, Rosalie Sears, Mu-Shui Dai. (2011) Ribosomal protein L11 recruits miR-24/miRISC to suppress c-Myc in response to ribosomal stress. Mol Cell Biol, 31(19): 4007-4021
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