Headshot photo of Matthew Butler, Ph.D.

Matthew Butler, Ph.D.

  • Associate Professor, Oregon Institute of Occupational Health Sciences
  • Behavioral Neuroscience Graduate Program, School of Medicine


I have a broad interest in how biological clocks are synchronized in organisms, and how these affect physiology and behavior. I have a particular interest in how shift work increases the risk for disease. Current efforts employ behavioral and physiological approaches in order to investigate the following:

1)    Androgen receptors and sex differences in the biological clock
2)    The effects of shift work on fertility
3)    Sleep epidemiology

Education and training

    • A.B., 1999, Dept. of Ecology and Evolutionary Biology, Princeton University
    • Ph.D., 2007, Dept. of Integrative Biology, U.C. Berkeley

Memberships and associations:

  • Society for Research on Biological Rhythms
  • American Association of Sleep Medicine
  • Sleep Research Society
  • Society for Neuroscience

Areas of interest

  • Biological rhythms and health
  • Neuroendocrinology of sex differences
  • Sleep epidemiology


Selected publications

  • Grygoryev D, Rountree MR, Rwatambuga F, Ohlrich A, Kukino A, Butler MP, Allen CN, Turker MS. In Press. Rapid response and slow recovery of the H3K4me3 epigenomic marker in the liver after a light-mediated phase advance of the circadian clock. Journal of Biological Rhythms.
  • Thosar SS, Butler MP, Shea SA. In Press. Role of the circadian system in cardiovascular disease. Journal of Clinical Investigation.
  • Butler MP, Smales C, Wu H, Hussain MV, Mohamed YA, Morimoto M, Shea SA. 2015. The circadian system contributes to apnea lengthening across the night in obstructive sleep apnea. Sleep 38: 1793-1801.
  • Butler MP, Karatsoreos IN, LeSauter J, Silver R. 2012. Dose-dependent effects of androgens on the circadian timing system and its response to light. Endocrinology. 153: 2344-2352.
  • Butler MP, Silver R.  2011. Divergent photic thresholds in the non-image forming visual system: entrainment, masking, and pupillary light reflex. Proceedings of the Royal Society B: Biological Sciences. 278: 745-750.


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