Headshot photo of Mathew Thayer, Ph.D.

Mathew Thayer, Ph.D.

  • Professor of Chemical Physiology and Biochemistry, School of Medicine
  • Biochemistry and Molecular Biology Graduate Program, School of Medicine
  • Molecular and Medical Genetics Graduate Program, School of Medicine
  • Cancer Biology Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine


College: California State University, Chico, CA; Graduated June, 1982; Bachelor of Arts in Microbiology and Chemistry

Graduate Education:  University of Southern California; Department of Microbiology; Los Angeles, CA; Graduated June, 1988; Doctor of Philosophy in Microbiology; Dr. R.E.K. Fournier, PhD, advisor

Education and training

  • Degrees

    • B.A., 1982, California State University, Chico
    • Ph.D., 1988, University of Southern California

Memberships and associations:

  • Biochemistry & Molecular Biology, Molecular & Medical Genetics, Program in Molecular & Cellular Biosciences, Cancer Biology Graduate Program

Areas of interest

  • chromosome dynamics

Honors and awards

  • John A. Resko Faculty Research Achievement and Mentoring Award, 2017


Selected publications

  • Smith l., Plug A. and Thayer M. Delayed Replication Timing Leads to Delayed Mitotic Chromosome Condensation of Chromosome Translocations. Proc Natl Acad Sci (2001) 98:13300-05. (PMCID:PMC60865).
  • Breger, K. S., Smith, L. Thayer, M. J. Engineering translocations with delayed replication: Evidence for cis control of chromosome replication timing. Hum Mol Gen (2005) 14: 2813-27. (PMID: 16115817).
  • Chang, B.H., Smith, L., Huang, J. and Thayer, M. Chromosomes with delayed replication timing lead to checkpoint activation, delayed recruitment of Aurora B and chromosome instability. Oncogene (2007) 26:1852-61. (PMCID:PMC3285441).
  • Stoffregen, E.P., Donley, N., Stauffer, D., Smith, L. and Thayer, M.J. An autosomal locus that controls chromosome-wide replication timing and mono-allelic expression. Hum Mol Genet, (2011) 20, 2366-78. (PMCID:PMC3098730).
  • Thayer, M.J. Mammalian chromosomes contain cis-acting elements that control replication timing, mitotic condensation, and stability of entire chromosomes. Bioessays. (2012) 34:760-70. (PMCID:PMC3517107).
  • Donley N., Stoffregen E.P., Smith L., Montagna C., Thayer M.J. Asynchronous Replication, Mono-Allelic Expression, and Long Range Cis-Effects of ASAR6. PLoS Genet (2013) 9:Epub 2013 Apr 4. (PMCID:PMC3617217).
  • Donley, N., Smith L., and Thayer M.J. ASAR15, a cis-Acting Locus that Controls Chromosome-Wide Replication Timing and Stability of Human Chromosome 15. PLoS Genet (2015) 11: e1004923. (PMCID: PMC4287527)


  • {{ pub.journalAssociation.journal.name.text[0].value }}