Photo of Markus Grompe, M.D.

Markus Grompe M.D.

  • (503) 494-8307
    • Professor of Pediatrics School of Medicine
    • Ray Hickey Chair of the of Pape' Family Pediatric Research Institute Pediatrics School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. Markus Grompe is the Ray Hickey Professor and Director of the Papé Family Pediatric Research Institute at Oregon Health & Science University in Portland, Oregon, USA. His research has focused on the use of in vivo selection to enhance gene and cell transplantation therapy for inherited diseases. Hepatic stem cells and their use in therapeutic liver repopulation are a main focus. To study the properties of human cells in a physiologic setting the laboratory has developed murine models supporting the expansion of human stem cells in transgenic mice.  These humanized mice are an ideal platform for the development for novel therapeutics, including small molecules, gene therapy vectors and cells. He has published over 200 peer-reviewed articles and holds numerous patents.

Education

  • M.D., University of Ulm Medical School, 0 Germany 1983
  • Residency:

    • Pediatrics, Oregon Health & Science University, Portland, 1987
  • Fellowship:

    • Genetics, Baylor College of Medicine, Houston, TX, 1991
  • Certifications:

    • Clinical Genetics

Memberships and associations

  • Diplomat of the American Board of Human Genetics

Publications

  • "Aneuploidy as a mechanism for stress-induced liver adaptation" Journal of Clinical Investigation September 4 2012
  • "Assessing the potential of induced liver regeneration." Nature Medicine September 2013
  • "Mouse liver goes human" Hepatology  2001
  • "Bone marrow-derived hepatocytes"   2005
  • "The Ashkenazi Jewish fanconi anemia mutations" Human Mutation  1994
  • "In vivo suppressor mutations correct a murine model of hereditary tyrosinemia type I" Proceedings of the National Academy of Sciences of the United States of America October 12 1999
  • "Preclinical protocol for in vivo selection of hematopoietic stem cells corrected by gene therapy in fanconi anemia group C" Molecular Therapy  2001
  • "Nucleotide sequence of a cDNA encoding murine fumarylacetoacetate hydrolase" Molecular Genetics and Metabolism  1992
  • "Rapid assessment of fanconi pathway function" Blood  2000
  • "William B. Hurlbut, Robert P. George, and Markus Grompe reply [4]" Hastings Center Report November 2006
  • "Embryonic stem cells without embryos?" Biotechnology December 2005
  • "Surface markers for the murine oval cell response" Hepatology October 2008
  • "Adult versus embryonic stem cells" Molecular Therapy September 1 2002
  • "Principles of therapeutic liver repopulation" Journal of Inherited Metabolic Disease April 2006
  • "Cell fusion is the principal source of bone-marrow-derived hepatocytes" Nature April 24 2003
  • "Signaling networks in hepatic oval cell activation" Stem Cell Research November 2008
  • "Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin" Blood February 1 2005
  • "Tumor necrosis factor-α and CD95 ligation suppress erythropoiesis in Fanconi anemia C gene knockout mice" Journal of Cellular Physiology  1999
  • "In vivo correction of murine tyrosinemia type I by DNA-mediated transposition" Molecular Therapy December 1 2002
  • "BRCA1 interacts directly with the Fanconi anemia protein FANCA" Human Molecular Genetics October 1 2002
  • "In vivo correction of murine hereditary tyrosinemia type I by φC31 integrase-mediated gene delivery" Molecular Therapy March 2005
  • "DNA replication is required to elicit cellular responses to psoralen-induced DNA interstrand cross-links" Molecular and Cellular Biology  2000
  • "Adult Liver Stem Cells"  September 14 2004
  • "The fanconi anaemia/BRCA pathway" Nature Reviews Cancer January 2003
  • "Report of the sixth international workshop on human chromosome 3 mapping 1995" Cytogenetic and Genome Research  1996
  • "AAV-mediated gene targeting is significantly enhanced by transient inhibition of nonhomologous end joining or the proteasome in vivo" Human Gene Therapy June 1 2012
  • "Discussion"   2005
  • "Stem Cells and Liver Regeneration" Gastroenterology August 2009
  • "Fanconi anemia group A and C double-mutant mice" Experimental Hematology  2002
  • "Human pancreatic cancer fusion 2 (HPC2) 1-B3" Cancer cytopathology January 2013

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