Photo of Luiz Eduardo Bertassoni, D.D.S., Ph.D.

Luiz Eduardo Bertassoni D.D.S., Ph.D.

  • (503) 494-8763

    Portland Campus

    • Associate Professor of Restorative Dentistry School of Dentistry
    • CEDAR Member OHSU Knight Cancer Institute School of Medicine
    • Biomedical Engineering Graduate Program School of Medicine

Dr. Luiz E. Bertassoni graduated with a DDS degree from Pontifical Catholic University of Parana (PUCPR) in Brazil, obtained a PhD in Biomaterials and Bioengineering from University of Sydney, and two postdoctoral degrees from University of California San Francisco, and the Harvard-MIT Division of Health Sciences and Technology. Currently, Dr. Bertassoni is an Assistant Professor at Oregon Health and Science University-School of Dentistry. He also holds appointments at the OHSU Center for Regenerative Medicine and Department of Biomedical Engineering at OHSU School of Medicine. Luiz is also a honorary lecturer in Biomaterials and Bioengineering at University of Sydney-School of Dentistry. Dr. Bertassoni leads a multidisciplinary research group working on various aspects of biomaterials and tissue engineering. His   recent  work  on  bioprinting  for vascularization of tissue engineering constructs has received extensive attention in the popular media, including Fox News, BBC, The Guardian, Fox Business, Wired.com, Tech Crunch, etc; and was recently selected as one of the top 100 science stories of 2014 (#64) by Discover Magazine. Luiz is a recipient of over 20 national and international research awards, 9 competitive research grants and has received over $3 Million in research funding. Luiz currently serves as an ad-hoc reviewer or editorial board member for over 30 journals. Dr. Bertassoni's research studies the use micro-scale technologies and bioprinting for tissue engineering; nanoscale structural and mechanical properties of mineralized tissues; and different aspects of the emerging field of ‘organs-on-a-chip’.

Education

  • D.D.S., Pontifícia Universidade Católica do Paraná Pontifícia Universidade Católica do Paraná Brazil 2007
  • Ph.D., University of Sydney, Sydney Australia 2012
  • Fellowship:

    • Postdoctoral Fellow, Harvard Medical School 2012-2013
    • Postdoctoral Research Fellow, Brigham and Women's Hospital 2012-2013
    • Postdoctoral Fellow, University of California, San Francisco 2007-2009

Publications

  • "Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs" Lab on a Chip - Miniaturisation for Chemistry and Biology July 7 2014
  • "Influence of hydration on nanoindentation induced energy expenditure of dentin" Journal of Biomechanics June 1 2012
  • "Effect of tooth bleaching agents on protein content and mechanical properties of dental enamel" Acta Biomaterialia July 1 2015
  • "The contribution of proteoglycans to the mechanical behavior of mineralized tissues" Journal of the Mechanical Behavior of Biomedical Materials  2014
  • "Insights into the structure and composition of the peritubular dentin organic matrix and the lamina limitans" Micron February 2012
  • "Evaluation of surface structural and mechanical changes following remineralization of dentin" Scanning September 2010
  • "Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels" Biofabrication  2014
  • "Effect of pre- and postpolymerization on flexural strength and elastic modulus of impregnated, fiber-reinforced denture base acrylic resins" Journal of Prosthetic Dentistry December 2008
  • "25th anniversary article" Advanced Materials January 8 2014
  • "Three-Dimensional Bioprinting for Regenerative Dentistry and Craniofacial Tissue Engineering" Journal of Dental Research September 24 2015
  • "Effects of benzodiazepine and pilocarpine on rat parotid glands" Medicinal Chemistry  2009
  • "Papain-gel degrades intact nonmineralized type I collagen fibrils" Scanning November 2009
  • "The role of proteoglycans in the nanoindentation creep behavior of human dentin" Journal of the Mechanical Behavior of Biomedical Materials March 1 2015
  • "Mechanical recovery of dentin following remineralization in vitro - An indentation study" Journal of Biomechanics January 4 2011
  • "In-office dental bleaching and enamel microabrasion for fluorosis treatment" Journal of Clinical Pediatric Dentistry March 2008
  • "Mechanical heterogeneity of dentin at different length scales as determined by AFM phase contrast" Micron December 2012
  • "Biomechanical perspective on the remineralization of dentin" Caries Research March 2009
  • "Nanotechnology in dental sciences" Materials  2010
  • "Engineering pre-vascularized scaffolds for bone regeneration"   2015
  • "The dentin organic matrix - Limitations of restorative dentistry hidden on the nanometer scale" Acta Biomaterialia July 2012
  • "Effect of additives on the compressive strength and setting time of a Portland cement" Pesquisa odontologica brasileira = Brazilian oral research April 2010
  • "Preface" Advances in Experimental Medicine and Biology  2015
  • "Immunolocalization and distribution of proteoglycans in carious dentine" Australian Dental Journal September 1 2016
  • "Removal of dentin non-collagenous structures results in the unraveling of microfibril bundles in collagen type I" Connective Tissue Research October 30 2016
  • "Surface roughness of restoration margin preparations" International Journal of Periodontics and Restorative Dentistry  2015
  • "No additional benefit of using a calcium hydroxide liner during stepwise caries removal. A randomized clinical trial" Journal of the American Dental Association  2017
  • "Dentin on the nanoscale" Dental Materials December 1 2016
  • "A Novel Strategy to Engineer Pre-Vascularized Full-Length Dental Pulp-like Tissue Constructs" Scientific Reports December 1 2017
  • "Biomaterials for Oral Health" Dental Clinics of North America  2017
  • "Biomaterials for Craniofacial Bone Regeneration" Dental Clinics of North America October 1 2017

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