Photo of Louis Jeffrey Picker, M.D.

Louis Jeffrey Picker M.D.

    • Professor VGTI-Vaccine and Gene Therapy Institute
    • Molecular Microbiology and Immunology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Louis Picker graduated from UCLA with a B.S. in bacteriology in 1978 and took his M.D. degree at the University of California at San Francisco in 1982. After residency training in pathology at Beth Israel Hospital, Boston, and postdoctoral training in immunology at Stanford University Medical Center, he was appointed assistant professor and then associate professor of pathology at the University of Texas Southwestern Medical Center at Dallas. In 1999 he came to OHSU and ONPRC as professor of pathology/molecular microbiology and immunology in the OHSU School of Medicine and head of the Division of Pathobiology and Immunology.

Areas of interest

  • Human and primate T cell biology
  • Immunologic Memory
  • Vaccine Development

Education

  • B.S., UCLA, Los Angeles California United States 1978
  • M.D., UCSF, San Francisco California United States 1982

Publications

Selected publications

  • Burwitz BJ, Malouli D, Bimber BN, Reed JS, Ventura AB,Hancock MH, Uebelhoer LS, Bhusari A, Hammond KB, Espinosa Trethewy RG, Klug A, Legasse AW, Axthelm MK, Nelson JA, Park BS, Streblow DN, Hansen SG, Picker LJ,Früh K, Sacha JB. Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques. PLoS Pathog. 2016 Nov 9;12(11):e1006014. doi:10.1371/journal.ppat.1006014.[PMID: 27829026]

  • Ranasinghe S, Lamothe PA, Soghoian DZ, Kazer SW, Cole MB,Shalek AK, Yosef N, Jones RB, Donaghey F, Nwonu C, Jani P, Clayton GM, CrawfordF, White J, Montoya A, Power K, Allen TM, Streeck H, Kaufmann DE, Picker LJ,Kappler JW, Walker BD; Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit ClonalExpansion. Immunity.2016 Oct 18;45(4):917-930. doi:10.1016/j.immuni.2016.09.015. [PMID: 27760342]

  • Greene JM, Dash P, Roy S, McMurtrey C, Awad W, Reed JS,Hammond KB, Abdulhaqq S, Wu HL, Burwitz BJ, Roth BF, Morrow DW, Ford JC, Xu G,Bae JY, Crank H, Legasse AW, Dang TH, Greenaway HY, Kurniawan M, Gold MC, Harriff MJ, Lewinsohn DA, Park BS, Axthelm MK, Stanton JJ, Hansen SG, PickerLJ, Venturi V, Hildebrand W, Thomas PG, Lewinsohn DM, Adams EJ, Sacha JB; MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates. Mucosal Immunol. 2016 Oct 19.doi: 10.1038/mi.2016.91. [PMID: 2775902]

  • Theiler J, Yoon H, Yusim K, Picker LJ, Fruh K, Korber B. Epigraph:A Vaccine Design Tool Applied to an HIV Therapeutic Vaccine and a Pan-Filo virus Vaccine. Sci Rep. 2016 Oct 5;6:33987. doi: 10.1038/srep33987.[PMID: 27703185]

  • Sturgill ER, Malouli D, Hansen SG, Burwitz BJ, Seo S,Schneider CL, Womack JL, Verweij MC, Ventura AB, Bhusari A, Jeffries KM,Legasse AW, Axthelm MK, Hudson AW, Sacha JB, Picker LJ, Früh K. Natural KillerCell Evasion Is Essential for Infection by Rhesus Cytomegalovirus. PLoS Pathog.2016 Aug 31;12(8):e1005868. doi: 10.1371/journal.ppat.1005868.[PMID: 27580123]

Publications

  • "Antigen-presenting capabilities of human monocytes correlates with their expression of HLA-DS, an Ia determinant distinct from HLA-DR" Journal of Immunology  1983
  • "Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infection" Journal of Virology  2002
  • "Naïve and memory B cells in the rhesus macaque can be differentiated by surface expression of CD27 and have differential responses to CD40 ligation" Journal of Immunological Methods January 5 2011
  • "Evasion of CD8+ T Cells Is Critical for Superinfection by Cytomegalovirus" Science April 2 2010
  • "Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection" Journal of Experimental Medicine November 15 2004
  • "Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow" Blood February 1 1992
  • "Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques" Journal of Immunology August 15 2011
  • "Putative immunodominant human immunodeficiency virus-specific CD8+ T-cell responses cannot be predicted by major histocompatibility complex class I haplotype" Journal of Virology  2000
  • "Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys" Journal of Virology May 2007
  • "HIV" Nature  2013
  • "Absence of clonal beta and gamma T-cell receptor gene rearrangements in a subset of peripheral T-cell lymphomas" American Journal of Pathology  1988
  • "Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms" Science  2013
  • "Dendritic cell ontogeny" Proceedings of the National Academy of Sciences of the United States of America November 11 1997
  • "Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry" Journal of Immunological Methods March 1 1998
  • "Numbers of host 'helper' T cells and proliferating cells predict survival in diffuse small-cell lymphomas" Journal of Clinical Oncology  1989
  • "Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239" Journal of Virology June 2006
  • "Progressive CD4+ central-memory T cell decline results in CD4+ effector-memory insufficiency and overt disease in chronic SIV infection" Journal of Experimental Medicine September 3 2007
  • "H-CAM expression in the human nervous system" Journal of Neurocytology May 1992
  • "IL-15 induces CD4+ effector memory T cell production and tissue emigration in nonhuman primates" Journal of Clinical Investigation June 1 2006
  • "Heterogeneity of CD4+ and CD8+ T-cell responses to cytomegalovirus in HIV-infected and HIV-uninfected men who have sex with men" Journal of Infectious Diseases August 1 2014
  • "Support for the RV144 HIV vaccine trial [1] (multiple letters)" Science July 9 2004
  • "Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production" Journal of Experimental Medicine February 1 1995
  • "Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry. Evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency" Journal of Clinical Investigation April 1 1997
  • "Analysis of the immune response and viral evolution during the acute phase of SIV infection" Vaccine May 6 2002
  • "B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers" Nature Medicine  2015
  • "Effect of IL-7 therapy on naive and memory T cell homeostasis in aged rhesus macaques" Journal of Immunology November 1 2015
  • "Expression of LFA-1 in non-Hodgkin's lymphoma" Cancer  1989
  • "Regulation of tissue-selective T-lymphocyte homing receptors during the virgin to memory/effector cell transition in human secondary lymphoid tissues" American Journal of Respiratory and Critical Care Medicine  1993
  • "Vaccine-induced linear epitope-specific antibodies to simian immunodeficiency virus SIVmac239 envelope are distinct from those induced to the human immunodeficiency virus type 1 envelope in nonhuman primates" Journal of Virology  2015
  • "Clonotypic structure of the human CD4+ memory T cell response to cytomegalovirus" Journal of Immunology August 1 2001

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