Lisa Vrooman, Ph.D.

  • Assistant Professor, Oregon National Primate Research Center

Biography

Lisa Vrooman is an Assistant Professor in the Division of Reproductive and Developmental Sciences at the Oregon National Primate Research Center (ONPRC).

 In 2018, over 8 million babies had been born using ART, and use will continue to increase as access becomes more available and technology/protocols improve the probability of a live birth. In the United States, approximately 2% of live births are conceived using ART. ART pregnancies are associated with increased risk low birth weight, abnormal placentation, congenital defects, preterm delivery, preeclampsia, and other pregnancy complications. ART-conceived people are also a relatively young population—there is little to no existing data examining how ART impacts health at middle or old age. Aligned with this clinically-relevant gap in knowledge, the Vrooman lab focuses on understanding and improving the molecular, cellular, and long-term physiological outcomes of ART procedures. A priority research question is determining how exposures during critical windows of development, like ART, can contribute to pregnancy/neonatal complications, and even lead to pathological states later in adulthood. The Vrooman lab will leverage the power of the mouse and non-human primate models as well as human samples to conduct translational research with the goal of optimizing protocols to improve maternal and fetal outcomes.

 Lisa’s research training in reproductive biology began as an undergraduate at California State University Long Beach with Dr. Kelly Young. She then obtained her PhD with Dr. Patricia Hunt at Washington State University. Her dissertation work demonstrated how both paternal age and exposure to endocrine disrupting chemicals could influence spermatogenesis, potentially affecting sperm count and paternal inheritance in offspring using a mouse model. After receiving her PhD, she conducted postdoctoral studies at the University of Pennsylvania with Dr. Marisa Bartolomei. Her project focused on determining how epigenetic changes incurred during Assisted Reproductive Technologies (ART) impact placentation and fetal growth. Along with her colleagues, she demonstrated that embryo culture leads to placental overgrowth and an increase in the preeclampsia risk factor, sFlt1, in a mouse model. These placental phenotypes were associated with both a global loss of placental DNA methylation and a local loss at imprinted genes, which are known to be important for development and notably, normally protected from methylation loss. That work was funded in part by the National Centers for Translational Research in Reproduction and Infertility (NCTRI) grant, The Lalor Foundation, and a Ruth L. Kirschstein Postdoctoral Individual National Research Service Award.

Education and training

    • B.S., 2008, California State University Long Beach
    • Ph.D., 2014, Washington State University
  • Fellowship

    • Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship, 2017-2020
    • b. The Lalor Foundation Postdoctoral Fellowship, 2015-2017
    • WSU Graduate School Research Fellowship, 2012-2014
    • John and Neva Abelson Graduate Fellowship, 2009
    • Stephen Fodor and Janelle Benoit Graduate Fellowship, 2008

Areas of interest

  • Development Origins of Health and Disease
  • Environmental Health
  • Epigenetics
  • Assisted Reproductive Technologies
  • Gametogenesis
  • Pregnancy

Honors and awards

  • Biorender Graphical Abstract Award, 2020
  • Society for the Study of Reproduction Annual Meeting Lalor Foundation Merit Award, 2019
  • Best Oral Presentation at the International Federation of Placental Associations meeting, 2018
  • Elsevier Award for Early Career Researchers for International Federation of Placental Associations meeting, 2018
  • NIH travel award for International Federation of Placental Associations meeting, 2017
  • California State University Chancellor’s Doctoral Incentive Program Mini-Grant, 2012
  • NICHD-sponsored scholarship to attend the Frontiers in Reproduction training course at the Marine Biological Laboratory, Woods Hole, MA, 2012
  • Graduate & Professional Student Association Travel Grant Award, 2012
  • Dr. Bruce Gibbins Travel Award from the School of Molecular Biosciences, 2012
  • WSU College of Veterinarian Medicine Pfizer Student Research Symposium 1st place poster presentation, 2011
  • California State University Chancellor’s Doctoral Incentive Program (forgivable loan program), 2009
  • Robert D. Rhodes Award (CSULB College of Natural Sciences and Mathematics, Biological Science Department’s most outstanding graduating senior), 2008
  • CSULB Biological Sciences Departmental Honors Award, 2008
  • Beckman Scholar Program- Arnold and Mabel Beckman Foundation, 2007-2008
  • Research Training Initiative for Student Enhancement (U-RISE, T34) Program (terminated early), 2007
  • Frank Schatzlein Scholarship Award, 2007
  • Howell-CSUPERB Student Research Fellow Award, 2006

Publications

Selected publications

  • Vrooman LA, Rhon-Calderon EA, Chao OY, Nguyen DK, Narapareddy L, Dahiya AK, Putt ME, Schultz RM, Bartolomei MS. Assisted reproductive technologies induce temporally specific placental defects and the preeclampsia risk marker sFLT1 in mouse. Development. 2020 May 29;147(11):dev186551. doi: 10.1242/dev.186551. PMID: 32471820; PMCID: PMC7272348.
  • Rhon-Calderon EA, Vrooman LA, Riesche L, Bartolomei MS. The effects of Assisted Reproductive Technologies on genomic imprinting in the placenta. Placenta. 2019 Sep 1;84:37-43. doi: 10.1016/j.placenta.2019.02.013. Epub 2019 Mar 4. PMID: 30871810.
  • Vrooman LA, Bartolomei MS. Can assisted reproductive technologies cause adult-onset disease? Evidence from human and mouse. Reprod Toxicol. 2017 Mar;68:72-84. doi: 10.1016/j.reprotox.2016.07.015. Epub 2016 Jul 26. PMID: 27474254; PMCID: PMC5269604.
  • Vrooman LA, Xin F, Bartolomei MS. Morphologic and molecular changes in the placenta: what we can learn from environmental exposures. Fertil Steril. 2016 Sep 15;106(4):930-40. doi: 10.1016/j.fertnstert.2016.08.016. Epub 2016 Aug 11. PMID: 27523298; PMCID: PMC5026950.
  • de Waal E, Vrooman LA, Fischer E, Ord T, Mainigi MA, Coutifaris C, Schultz RM, Bartolomei MS. The cumulative effect of assisted reproduction procedures on placental development and epigenetic perturbations in a mouse model. Hum Mol Genet. 2015 Dec 15;24(24):6975-85. doi: 10.1093/hmg/ddv400. Epub 2015 Sep 23. PMID: 26401051; PMCID: PMC4654053.
  • Vrooman LA, Oatley JM, Griswold JE, Hassold TJ, Hunt PA. Estrogenic exposure alters the spermatogonial stem cells in the developing testis, permanently reducing crossover levels in the adult. PLoS Genet. 2015 Jan 23;11(1):e1004949. doi: 10.1371/journal.pgen.1004949. PMID: 25615633; PMCID: PMC4304829.
  • Peretz J, Vrooman L, Ricke WA, Hunt PA, Ehrlich S, Hauser R, Padmanabhan V, Taylor HS, Swan SH, VandeVoort CA, Flaws JA. Bisphenol a and reproductive health: update of experimental and human evidence, 2007-2013. Environ Health Perspect. 2014 Aug;122(8):775-86. doi: 10.1289/ehp.1307728. Epub 2014 Jun 4. PMID: 24896072; PMCID: PMC4123031.
  • Vrooman LA, Nagaoka SI, Hassold TJ, Hunt PA. Evidence for paternal age-related alterations in meiotic chromosome dynamics in the mouse. Genetics. 2014 Feb;196(2):385-96. doi: 10.1534/genetics.113.158782. Epub 2013 Dec 6. PMID: 24318536; PMCID: PMC3914612.
  • Vrooman LA, Young KA. Ovarian matrix metalloproteinases are differentially regulated during the estrous cycle but not during short photoperiod induced regression in Siberian hamsters (Phodopus sungorus). Reprod Biol Endocrinol. 2010 Jun 25;8:79. doi: 10.1186/1477-7827-8-79. PMID: 20579366; PMCID: PMC2913988.

Publications

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