Photo of Leslie Myatt, Ph.D., FRCOG

Leslie Myatt Ph.D., FRCOG

  • (503) 418-2781
    • Professor of Obstetrics and Gynecology School of Medicine
    • Endowed Professor and Associate Director, Bob and Charlee Moore Institute of Nutrition and Wellness
    • Director of Perinatal Research Obstetrics and Gynecology School of Medicine

Dr. Myatt was born and raised in Yorkshire, England and received both his BSc and PhD from the University of London, UK. He moved to Oregon in 2015 having previously been a faculty member at the University of Texas Health Science Center San Antonio, and at the University of Cincinnati, where he was Director of the NIH-funded Physician Scientist Training Program (MD/PhD) and the Women’s Reproductive Health Research Scholars Program. Dr. Myatt served as Editor of the journal Placenta (1997 to 2004), President of the Perinatal Research Society (1997), President of the International Federation of Placenta Associations (2002 to 2004) and President of the Society for Gynecologic Investigation (2009 to 2010).

He is internationally known for his research which applies basic science approaches to clinical problems in perinatology, including preeclampsia, preterm birth and gestational diabetes. His research interests include control of fetal placental vascular reactivity, the role of obesity, oxidative and nitrative stress in placental function and fetal programming and the regulation of prostaglandin synthesis and action in intrauterine tissues at parturition. He has published over 270 papers and 350 abstracts and has served on many review panels and study sections for NIH, CIHR and other international grant giving bodies. Dr. Myatt is also a member of the Global Pregnancy Collaboration (CoLab), which works with maternal and fetal medicine researchers around the globe to facilitate research addressing adverse pregnancy outcomes.

He was elected as a Fellow (ad eundem) of the Royal College of Obstetricians and Gynaecologists in 2013 for his contributions to women’s health research and has been presented with the Naftolin Award for Mentorship and the Distinguished Scientist Award by the Society for Reproductive Investigation.

His passions in life are his family, mentorship and soccer. Memorable moments include meeting his wife, helicopter skiing and being embraced by Stevie Wonder!

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Areas of interest

  • Perinatology
  • Placental function

Education

  • B.Sc., University of London, London United Kingdom 1972
  • Ph.D., University of London, London United Kingdom 1979

Memberships and associations

  • Society for Reproductive Investigation
  • Endocrine Society

Publications

  • "Can changes in angiogenic biomarkers between the first and second trimesters of pregnancy predict development of pre-eclampsia in a low-risk nulliparous patient population?" BJOG: An International Journal of Obstetrics and Gynaecology September 2013
  • "Vitamin C and e supplementation to prevent spontaneous preterm birth" Obstetrics and Gynecology September 2010
  • "Adverse pregnancy outcomes among women with prior spontaneous or induced abortions" American Journal of Perinatology  2014
  • "Myometrial prostaglandin E2 synthetic enzyme mRNA expression" Molecular Human Reproduction  2006
  • "Protein Nitration in Placenta - Functional Significance" Placenta December 2008
  • "Placental mechanisms and developmental origins of health and disease"  January 1 2006
  • "Regional expression of prostaglandin E2 and F2alpha receptors in human myometrium, amnion, and choriodecidua with advancing gestation and labor" Biology of Reproduction August 2006
  • "Hormonal regulation of prostaglandin E2 receptors" Reproductive Sciences February 2010
  • "Post-Translational Modifications of the P2X4 Purinergic Receptor Subtype in the Human Placenta are Altered in Preeclampsia" Placenta April 2007
  • "The utility of uterine artery doppler velocimetry in prediction of preeclampsia in a low-risk population" Obstetrics and Gynecology October 2012
  • "Localization and expression of prostaglandin E2 receptors in human placenta and corresponding fetal membranes with labor" American Journal of Obstetrics and Gynecology July 2006
  • "Differences in the proteome profile in placenta from normal term and preeclamptic preterm pregnancies" Proteomics - Clinical Applications May 2007
  • "Maternal insulin resistance and preeclampsia" American Journal of Obstetrics and Gynecology April 2011
  • "Prostanoid receptors in human uterine myocytes" Molecular Human Reproduction December 2006
  • "First-trimester prediction of preeclampsia in nulliparous women at low risk" Obstetrics and Gynecology June 2012
  • "Effect of Increasing Maternal Body Mass Index on Oxidative and Nitrative Stress in The Human Placenta" Placenta February 2009
  • "Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population" PLoS One April 3 2013
  • "Excessive early gestational weight gain and risk of gestational diabetes mellitus in nulliparous women" Obstetrics and Gynecology June 2012
  • "Pregnancy outcomes with weight gain above or below the 2009 institute of medicine guidelines" Obstetrics and Gynecology May 2013
  • "Pro-labour myometrial gene expression" Reproduction April 2008
  • "The rat uterine oestrogen receptor in relation to intra-uterine devices and the oestrous cycle [proceedings]" Biochemical Society Transactions  1977
  • "Endothelin transfer and endothelin effects on water transfer in human fetal membranes" Obstetrics and Gynecology  1992
  • "Immunohistochemical characterization of placental nitric oxide synthase expression in preeclampsia" American Journal of Obstetrics and Gynecology  1995
  • "Immunolocalization of the inducible nitric oxide synthase isoform in human fetal membranes" American Journal of Reproductive Immunology and Microbiology  1997
  • "Decreased nitric oxide production following extremity ischemia and reperfusion" American Journal of Surgery August 1996
  • "The expression of interleukin-15 and interleukin-18 by human term placenta is not affected by lipopolysaccharide" European Cytokine Network December 2007
  • "Identification and changes in concentrations of prostaglandin H synthase (PGHS) isoforms in rat myometrium at parturition" Prostaglandins and Other Lipid Mediators  1994
  • "Nitric oxide synthase activity in umbilical and placental vascular tissue of gestational diabetic pregnancies" Gynecologic and Obstetric Investigation  1997
  • "Enhancement of cortisol-induced 11β-hydroxysteroid dehydrogenase type 1 expression by interleukin 1β in cultured human chorionic trophoblast cells" Endocrinology May 2006
  • "Expression of progesterone receptor A form and its role in the interaction of progesterone with cortisol on cyclooxygenase-2 expression in amnionic fibroblasts" Journal of Clinical Endocrinology and Metabolism December 2009

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