Photo of Kirsten J. Lampi, M.S., Ph.D.

Kirsten J. Lampi M.S., Ph.D.

  • (503) 494-8620

    Portland Campus

    • Professor of Integrative Biosciences School of Dentistry

Education

  • Ph.D., Oregon Health & Science University, Portland Oregon 1992

Publications

Selected publications

  • Harms MJ, Wilmarth PA, Kapfer DM, Steel EA, David LL, Bachinger HP, Lampi KJ. Laser light-scattering evidence for an altered association of beta B1-crystallin deamidated in the connecting peptide.Protein Sci. 2004 Mar;13(3):678-86.

  • Kim YH, Kapfer DM, Boekhorst J, Lubsen NH, Bachinger HP, Shearer TR, David LL, Feix JB, Lampi KJ. Deamidation, but not truncation, decreases the urea stability of a lens structural protein, betaB1-crystallin. Biochemistry. 2002 Nov 26;41(47):14076-84.

  • Mackay DS, Boskovska OB, Knopf HL, Lampi KJ, Shiels A. A nonsense mutation in CRYBB1 associated with autosomal dominant cataract linked to human chromosome 22q. Am J Hum Genet. 2002;71(5):1216-21. Epub 2002 Oct 1.

  • Lampi KJ, Kim YH, Bachinger HP, Boswell BA, Lindner RA, Carver JA, Shearer TR, David LL, Kapfer DM. Decreased heat stability and increased chaperone requirement of modified human betaB1-crystallins. Mol Vis. 2002 Sep 25;8:359-66.

  • Lampi KJ, Shih M, Ueda Y, Shearer TR, David LL. Lens proteomics: analysis of rat crystallin sequences and two-dimensional electrophoresis map.Invest Ophthalmol Vis Sci. 2002 Jan;43(1):216-24.

Publications

  • "New focus on alpha-crystallins in retinal neurodegenerative diseases" Experimental Eye Research February 2011
  • "Deamidation alters interactions of β-crystallins in hetero-oligomers" Molecular Vision January 28 2009
  • "Tissue transglutaminase catalyzes the deamidation of glutamines in lens βB2- and βB3-crystallins" Experimental Eye Research February 2008
  • "Deamidation alters the structure and decreases the stability of human lens βA3-crystallin" Biochemistry July 31 2007
  • "Deamidation of human βB1 alters the elongated structure of the dimer" Experimental Eye Research  2001
  • "Increased thromboxane production in recalcified challenged whole blood from copper-deficient rats" Nutrition Research  1991
  • "A nonsense mutation in CRYBB1 associated with autosomal dominant cataract linked to human chromosome 22q" American Journal of Human Genetics November 1 2002
  • "Association of calpain with insoluble pellet of rat lens" Experimental Eye Research  1992
  • "Age-related changes of alpha-crystallin aggregate in human lens" Amino Acids January 2007
  • "Quantitative measurement of deamidation in lens βB2-crystallin and peptides by direct electrospray injection and fragmentation in a Fourier transform mass spectrometer" Molecular Vision December 28 2005
  • "Importance of nutrition for optimum health of the periodontium" Journal of Contemporary Dental Practice March 2001
  • "Identification and relatve amounts of crystallin polypeptides in rat, bovine, human and chick lenses" Investigative Ophthalmology and Visual Science  1997
  • "Human βB1-crystallin is partially degraded at its N-terminal extension during lens maturation" Investigative Ophthalmology and Visual Science February 15 1996
  • "Lens proteomics" Investigative Ophthalmology and Visual Science  2002
  • "The sequence of human and rat βA4-crystallin and possible implications for stability" Investigative Ophthalmology and Visual Science February 15 1996
  • "Differential binding of mutant (R116C) and wildtype alphaA crystallin to actin" Current Eye Research December 2007
  • "Ubiquitin proteasome pathway-mediated degradation of proteins" Investigative Ophthalmology and Visual Science August 2010
  • "Measurement of deamidation of intact proteins by isotopic envelope and mass defect with ion cyclotron resonance Fourier transform mass spectrometry" Rapid Communications in Mass Spectrometry  2006
  • "Decreased heat stability and increased chaperone requirement of modified human βB1-crystallins" Molecular Vision  2002
  • "Dietary copper and copper dependant superoxide dismutase in hepatic prostaglandin synthesis by rat liver homogenates" Nutrition Research  1988
  • "Deamidation in human lens βB2-crystallin destabilizes the dimer" Biochemistry March 14 2006
  • "Comparison of β-crystallin cleavage sites suggests that different proteolytic activities predominate in rat, human, and bovine lenses" Investigative Ophthalmology and Visual Science  1997
  • "Cleavage of beta crystallins during maturation of bovine lens." Molecular Vision February 27 1998
  • "Laser light-scattering evidence for an altered association of βB1-crystallin deamidated in the connecting peptide" Protein Science March 2004
  • "Solvent accessibility of βB2-crystallin and local structural changes due to deamidation at the dimer interface" Experimental Eye Research September 2010
  • "Changes in solvent accessibility of wild-type and deamidated βB2-crystallin following complex formation with αA-crystallin" Experimental Eye Research November 2012
  • "The sequence of human βB1 -crystallin cDNA allows mass spectrometric detection of βBl protein missing portions of its N-terminal extension" Journal of Biological Chemistry February 23 1996
  • "Sequence analysis of βA3, βB3, and βA4 crystallins completes the identification of the major proteins in young human lens" Journal of Biological Chemistry  1997
  • "Age-related changes in human lens crystallins identified by two- dimensional electrophoresis and mass spectrometry" Experimental Eye Research July 1998
  • "Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses" Toxicology and Applied Pharmacology  1992

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