Photo of Kimberly E. Beatty, Ph.D.

Kimberly E. Beatty Ph.D.

    • Associate Professor of Biomedical Engineering School of Medicine
    • Associate Professor of Physiology and Pharmacology School of Medicine
    • Biomedical Engineering Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine
    • OHSU Center for Spatial Systems Biomedicine School of Medicine

The Beatty group applies novel chemical tools and technologies towards illuminating human diseases.  When Dr. Beatty started her group at OHSU in 2012, she decided that her focus would be on using innovative and creative approaches to identify and investigate the molecular basis of human diseases, including tuberculosis (TB) and breast cancer.  Research in the Beatty group is collaborative and interdisciplinary.  Her team works on the following projects: 

1.1  Chemical tools for detecting hydrolase activities in Mycobacterium tuberculosis (Mtb).

1.2  Illuminating drug susceptibility in Mtb.

1.3  A new technology for tracking and mapping proteins by light and electron microscopy.

1.4  Identifying molecular interactions that confer drug resistance in breast cancer.

1.5  Synthesis of new fluorescent and fluorogenic probes.

Before joining the faculty at OHSU, Dr. Beatty earned her PhD in chemistry with Professor David Tirrell at Caltech. She completed her postdoc training at UC Berkeley with Professor Carolyn Bertozzi. 

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Areas of interest

  • Developing new chemical tools for illuminating human diseases

Education

  • B.S., University of California, Santa Barbara 2002
  • Ph.D., California Institute of Technology 2008

Publications

  • "Fluorescence visualization of newly synthesized proteins in mammalian cells" Angewandte Chemie - International Edition November 13 2006
  • "A BODIPY-cyclooctyne for protein imaging in live cells" ChemBioChem September 19 2011
  • "Selective dye-labeling of newly synthesized proteins in bacterial cells" Journal of the American Chemical Society October 19 2005
  • "Far-red fluorogenic probes for esterase and lipase detection" ChemBioChem  2015
  • "Cell-selective metabolic labeling of proteins" Nature Chemical Biology October 2009
  • "Reactivity of recombinant and mutant vanadium bromoperoxidase from the red alga Corallina officinalis" Journal of Inorganic Biochemistry July 25 2002
  • "Two-color labeling of temporally defined protein populations in mammalian cells" Bioorganic and Medicinal Chemistry Letters November 15 2008
  • "Live-cell imaging of cellular proteins by a strain-promoted azide-alkyne cycloaddition" ChemBioChem October 18 2010
  • "Bioluminescent probes of sulfatase activity" ChemBioChem October 18 2010
  • "An expanded set of fluorogenic sulfatase activity probes" ChemBioChem May 26 2014
  • "Chemical strategies for tagging and imaging the proteome" Molecular BioSystems August 1 2011
  • "Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains" Proceedings of the National Academy of Sciences of the United States of America August 6 2013
  • "Synthesis of a far-red fluorophore and its use as an esterase probe in living cells" Chemical Communications January 31 2016
  • "Profiling Esterases in Mycobacterium tuberculosis Using Far-Red Fluorogenic Substrates" ACS Chemical Biology July 15 2016
  • "Versatile Interacting Peptide (VIP) Tags for Labeling Proteins with Bright Chemical Reporters" ChemBioChem March 2 2017
  • "Small-Molecule Probes Reveal Esterases with Persistent Activity in Dormant and Reactivating Mycobacterium tuberculosis" ACS Infectious Diseases December 9 2016
  • "VIPER is a genetically encoded peptide tag for fluorescence and electron microscopy" Proceedings of the National Academy of Sciences of the United States of America December 18 2018

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