Photo of Kelvin D. MacDonald, M.D.

Kelvin D. MacDonald M.D.

    • Associate Professor of Pediatrics, Division of Pulmonology School of Medicine

Dr. MacDonald’s lab focuses on applied models of CF and airways disease electrophysiology by performing short circuit current measurements on cell and tissues. The lab has modeled several short chain fatty acid as modifiers of CFTR trafficking. The lab also performs mouse and human nasal potential difference testing. The lab has a unique model of survival mouse lung mechanics. Recently, we have been studying the effects of maternal on childhood lung health.

We have benefited from support from the NICHD, Parker B. Frances Foundation, Thrasher Research Foundation.


  • M.D., University of Sint Eustatius, Sint Eustatius Netherlands 2001
  • Residency:

    • Pediatrics, Akron Children’s Hospital, Northeast Ohio University College of Medicine, 2004
  • Fellowship:

    • Pediatric pulmonology, Johns Hopkins Medical Institutions, 2008
  • Certifications:

    • American Board of Pediatrics, General Pediatrics, 2008
    • American Board of Pediatrics, Pulmonology, 2010

Memberships and associations

  • American Thoracic Society


  • "Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway" American Journal of Physiology - Renal Fluid and Electrolyte Physiology January 2009
  • "Cystic fibrosis transmembrane regulator protein mutations" Paediatric Drugs  2007
  • "Oral antimicrobial use in outpatient cystic fibrosis pulmonary exacerbation management" Clinical Respiratory Journal January 2012
  • "Primary snoring and growth failure in a patient with cystic fibrosis" Respiratory Care December 2009
  • "Spontaneous desaturations in intubated very low birth weight infants with acute and chronic lung disease." Pediatric Pulmonology July 1992
  • "Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice" American Journal of Physiology - Renal Fluid and Electrolyte Physiology November 2008
  • "Aqueous cigarette smoke extract induces a voltage-dependent inhibition of CFTR expressed in Xenopus oocytes" American Journal of Physiology - Renal Fluid and Electrolyte Physiology February 1 2014
  • "A simple method of mouse lung intubation." Journal of visualized experiments : JoVE  2013
  • "An improved simple method of mouse lung intubation" Journal of Applied Physiology March 2009
  • "Tracheal bronchus in a 6-month-old infant identified by CT with three-dimensional airway reconstruction" Thorax January 2008
  • "Lubiprostone activates CFTR, but not ClC-2, via the prostaglandin receptor (EP4)" Biochemical and Biophysical Research Communications September 28 2012
  • "Maternal body mass index before pregnancy is associated with increased bronchodilator dispensing in early childhood" Pediatric Pulmonology August 1 2016
  • "Maternal high-fat diet in mice leads to innate airway hyperresponsiveness in the adult offspring" Physiological Reports March 1 2017
  • "Cost effectiveness of vitamin c supplementation for pregnant smokers to improve offspring lung function at birth and reduce childhood wheeze/asthma" Journal of Perinatology May 22 2018
  • "Prepregnancy extreme obesity is associated with increased steroid dispensing in early childhood" Pediatric, Allergy, Immunology, and Pulmonology June 1 2018
  • "Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis" Molecular Therapy January 1 2018
  • "The Effect of Extended Continuous Positive Airway Pressure on Changes in Lung Volumes in Stable Premature Infants" Journal of Pediatrics January 1 2019

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