Kathleen A. Grant, Ph.D.

  • Professor, Oregon National Primate Research Center
  • Professor of Behavioral Neuroscience, School of Medicine
  • Chief, Division of Neuroscience, Oregon National Primate Research Center
  • Behavioral Neuroscience Graduate Program, School of Medicine

Biography

Kathleen (Kathy) Grant, Ph.D. is Chief and Professor, Division of Neuroscience at the Oregon National Primate Research Center. Her scientific interests are in animal models of addiction, particularly alcoholism.

Her studies in non human primates are aimed at understanding the co-morbidity of stress and excessive alcohol drinking examining risk factors such genetics, in utero exposure, adolescent vulnerability, sex differences and menstrual cycle effects, brain adaptations and cognitive impairments.

Education

  • B.S., 1979, University of Santa Clara
  • M.S., 1982, University of Washington
  • Ph.D., 1984, University of Washington
  • Fellowship:

    • National Research Service Award, University of Chicago, 1984-1987

Honors and awards

  • 2009 - 2013 National Advisory Council, NIAAA
  • 2013 Henri Begleiter Excellence in Research Award, Research Society on Alcoholism
  • 2015 Master Lecture, 2015 American Psychological Association Convention
  • 2016-2018 President, Behavioral Pharmacology Society (BPS)
  • 2017 Plenary Lecture, Collaborative Perspectives on Addiction, APA

Memberships and associations

  • 1992- Alcoholism: Clinical and Experimental Research; 2001-present: Reviewing Editor
  • 1995- Behavioral Pharmacology
  • 2013- Alcohol
  • RSA, ASPET, SFN, APA, ISBRA

Areas of interest

  • Animal models of alcohol and drug addiction
  • Stress response to chronic alcohol drinking
  • MRI imaging of brain circuitry
  • Advances in cognitive assessment of primate behavior
  • Behavioral pharmacology

Publications

Selected publications

  • Sattgast LH, Branscum AJ, Jimenez VA, Newman N, Grant KA, Turner RT, Iwaniec UT. Between-subject and within-subject variability in measures of biochemical markers of bone turnover in cynomolgus and rhesus macaques. Bone Rep. 2021 Sep 5;15:101126. doi: 10.1016/j.bonr.2021.101126. PMID: 34541261; PMCID: PMC8436065.
  • Grant KA, Newman N, Gonzales S, Shnitko TA. Replicability in Measures of Attentional Set-Shifting Task Performance Predicting Chronic Heavy Drinking in Rhesus Monkeys. Alcohol. 2021 Sep 9:S0741-8329(21)00093-8. doi: 10.1016/j.alcohol.2021.08.006. Epub ahead of print. PMID: 34509594.
  • Lewis SA, Sureshchandra S, Doratt B, Jimenez VA, Stull C, Grant KA, Messaoudi I. Transcriptional, Epigenetic, and Functional Reprogramming of Monocytes From Non-Human Primates Following Chronic Alcohol Drinking. Front Immunol. 2021 Aug 20;12:724015. doi: 10.3389/fimmu.2021.724015. PMID: 34489976; PMCID: PMC8417707.
  • Lo JO, Schabel MC, Roberts VHJ, Morgan TK, Fei SS, Gao L, Ray KG, Lewandowski KS, Newman NP, Bohn JA, Grant KA, Frias AE, Kroenke CD. Effects of early daily alcohol exposure on placental function and fetal growth in a rhesus macaque model. Am J Obstet Gynecol. 2021 Aug 5:S0002-9378(21)00830-9. doi: 10.1016/j.ajog.2021.07.028. Epub ahead of print. PMID: 34364844.
  • Lopez-Cruzan M, Walter NAR, Sanchez JJ, Ginsburg BC, Koek W, Jimenez VA, Grant KA, Javors MA. Phosphatidylethanol in whole blood of rhesus monkeys correlates with ethanol consumption. Alcohol Clin Exp Res. 2021 Apr;45(4):689-696. doi: 10.1111/acer.14584. Epub 2021 Apr 19. PMID: 33616217; PMCID: PMC8150885.
  • Salinas AG, Mateo Y, Carlson VCC, Stinnett GS, Luo G, Seasholtz AF, Grant KA, Lovinger DM. Long-term alcohol consumption alters dorsal striatal dopamine release and regulation by D2 dopamine receptors in rhesus macaques. Neuropsychopharmacology. 2021 Jul;46(8):1432-1441. doi: 10.1038/s41386-020-00938-8. Epub 2021 Jan 15. PMID: 33452430; PMCID: PMC8209056.
  • Sattgast LH, Branscum AJ, Walter NAR, Newman N, Gonzales SW, Grant KA, Turner RT, Iwaniec UT. Effects of graded increases in ethanol consumption on biochemical markers of bone turnover in young adult male cynomolgus macaques. Alcohol. 2021 Mar;91:53-59. doi: 10.1016/j.alcohol.2020.12.003. Epub 2021 Feb 3. PMID: 33358984; PMCID: PMC7931631.
  • Jimenez VA, Walter NAR, Shnitko TA, Newman N, Diem K, Vanderhooft L, Hunt H, Grant KA. Mifepristone Decreases Chronic Voluntary Ethanol Consumption in Rhesus Macaques. J Pharmacol Exp Ther. 2020 Nov;375(2):258-267. doi: 10.1124/jpet.120.000169. Epub 2020 Sep 1. PMID: 32873623; PMCID: PMC7590013.
  • Lee MR, Shnitko TA, Blue SW, Kaucher AV, Winchell AJ, Erikson DW, Grant KA, Leggio L. Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques. Nat Commun. 2020 Jun 3;11(1):2783. doi: 10.1038/s41467-020-15942-1. PMID: 32494001; PMCID: PMC7270110.
  • Wang X, Cuzon Carlson VC, Studholme C, Newman N, Ford MM, Grant KA, Kroenke CD. In utero MRI identifies consequences of early-gestation alcohol drinking on fetal brain development in rhesus macaques. Proc Natl Acad Sci U S A. 2020 May 5;117(18):10035-10044. doi: 10.1073/pnas.1919048117. Epub 2020 Apr 20. PMID: 32312804; PMCID: PMC7211988.

Publications

  • {{ pub.journalAssociation.journal.name.text[0].value }}