Karina Nakayama, Ph.D. (she/her)

  • Associate Professor of Biomedical Engineering, School of Medicine
  • Co-Director, Biomedical Engineering Graduate Program, School of Medicine
  • Orthopaedics and Rehabilitation, School of Medicine

Biography

Dr. Nakayama is an Associate Professor in the Department of Biomedical Engineering (BME) and hold a joint appointment in the Department of Orthopaedics & Rehabilitation. She also holds an affiliate appointment at the Phil and Penny Knight Campus for Accelerating Scientific Impact at the University of Oregon. The overarching scientific mission of her research group is to develop therapeutic treatments for traumatic musculoskeletal injuries using regenerative bioengineering strategies. Specifically, the Nakayama group works on: 1) regenerative engineering of the musculoskeletal niche to treat severe nerve, muscle, and bone defects in extremity trauma; 2) rehabilitation engineering and rodent models of exercise to improve functional recovery and reduce pain following lower limb injury; 3) immune modulation of the regenerative niche through cell-based therapies and the rationale design of biomaterials; 4) age-dependencies of regenerative therapies.

Education and training

  • Degrees

    • B.S., 2007, University of California, San Diego
    • Ph.D., 2012, University of California, Davis
  • Fellowship

    • Postdoctoral Fellow, Stanford University, Stanford, California, 2019

Areas of interest

  • Engineering cells and tissues for the treatment of cardiovascular and musculoskeletal diseases
  • Modulation of inflammatory and angiogenic endothelial cell phenotype using nano-patterned and immunomodulatory biomaterials for the generation of athero-resistant small diameter vascular grafts
  • Using rehabilitative exercise to enhance innervation, immune-based muscle regeneration, and force recovery following traumatic volumetric tissue injury

Publications

Selected publications

  • Tan YH, Habing KM, Riesterer JL, Stempinksi ES, Lewis SH, Pfeifer CS, Malhotra SV, Nakayama KH. Engineered Nanofibrillar Collagen with Tunable Biophysical Properties for Myogenic, Endothelial, and Osteogenic Cell Guidance. Acta Biomaterialia, 186:95-107, 2024. PMC11407781
  • Habing KM, Alcazar CA, Duke VR, Tan YH, Willett NJ, Nakayama KH. Age-associated functional healing of musculoskeletal trauma through regenerative engineering and rehabilitation. Biomater Sci, 12(20):5186-5202, 2024. PMC11698469
  • Habing KM, Alcazar CA, Dobson N, Tan YH, Huang NF, Nakayama KH. Temporal Tissue Remodeling in Volumetric Muscle Injury with Endothelial Cell-Laden Patterned Nanofibrillar Constructs. Bioengineering 11(12):1269, 2024. PMC11673213
  • Habing KM, Tan YH, Nakayama KH. Production of Nanofibrillar Patterned Collagen for Tissue Engineering. J Vis Exp (211), e67165, 2024. PMID: 39373470
  • Alcazar CA, Hu C, Rando TA, Huang NF, Nakayama KH. Transplantation of Insulin-like growth factor-1 laden scaffold combined with exercise promotes neurovascular regeneration in a muscle injury preclinical model. Biomater Sci. 8:5376-5389, 2020. PMC7531607

Publications