Photo of Julie A. Saugstad, Ph.D.

Julie A. Saugstad Ph.D.

  • (503) 494-4926
    • Professor of Anesthesiology and Perioperative Medicine School of Medicine
    • Professor of Molecular and Medical Genetics School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Research Interests: Cell/Molecular Neurobiology, Signal Transduction, MicroRNA Regulation of Gene Expression, Extracellular Vesicles, Alzheimer's Disease, Neuroprotection.

Education

  • Ph.D., University of Oklahoma Health Sciences Center, Oklahoma City Oklahoma United States 1991
  • Fellowship:

    • Postdoctoral Fellow, Vollum Institute, 1991-1996

Memberships and associations

  • International Society for Extracellular Vesicles

Publications

  • "Sex differences and the role of PPAR alpha in experimental stroke" Metabolic Brain Disease November 18 2015
  • "A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a" Journal of Biological Chemistry August 3 2007
  • "MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration" Journal of Cerebral Blood Flow and Metabolism September 2010
  • "Ubiquitin-proteasome-mediated synaptic reorganization" Journal of Neuroscience January 2 2008
  • "Interaction of 14-3-3 with Bid during seizure-induced neuronal death" Journal of Neurochemistry July 2003
  • "L-2-amino-3-phosphonopropionic acid competitively antagonizes metabotropic glutamate receptors 1α and 5 in Xenopus oocytes" European Journal of Pharmacology - Molecular Pharmacology Section April 28 1995
  • "Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels" Journal of Neuroscience October 6 2004
  • "Polycomb group proteins as epigenetic mediators of neuroprotection in ischemic tolerance" Science Signaling March 2 2010
  • "Distribution of metabotropic glutamate receptor 7 messenger RNA in the developing and adult rat brain" Neuroscience  1995
  • "Cyclic AMP-dependent protein kinase phosphorylates group III metabotropic glutamate receptors and inhibits their function as presynaptic receptors" Journal of Neurochemistry  2001
  • "Effect of (S)-3,5-DHPG on microRNA expression in mouse brain" Experimental Neurology June 2012
  • "Regulatory CD8+CD122+ T-cells predominate in CNS after treatment of experimental stroke in male mice with IL-10-secreting B-cells" Metabolic Brain Disease  2015
  • "Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function" Molecular Pharmacology  2002
  • "NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin" Neuropharmacology  2005
  • "MicroRNAs as effectors of brain function" Stroke January 2013
  • "Sex differences in microRNA expression during developmentin rat cortex" Neurochemistry International  2014
  • "Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors" Molecular Pharmacology March 1994
  • "PD-L1 monoclonal antibody treats ischemic stroke by controlling central nervous system inflammation" Stroke  2015
  • "ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents" Journal of Neuroscience  2006
  • "Role for microglia in sex differences after ischemic stroke" Metabolic Brain Disease December 1 2015
  • "Immunohistochemical distribution of RGS7 protein and cellular selectivity in colocalizing with Gαq proteins in the adult rat brain" Journal of Neurochemistry  1999
  • "Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile" Molecular Pharmacology January 1997
  • "Ischemic preconditioning regulates expression of microRNAs and a predicted target, MeCP2, in mouse cortex" Journal of Cerebral Blood Flow and Metabolism April 2010
  • "Non-coding RNAs in stroke and neuroprotection" Frontiers in Neurology  2015
  • "MicroRNA responses to focal cerebral ischemia in male and female mouse brain" Frontiers in Molecular Neuroscience February 11 2014
  • "Rapid degradation of bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons" Journal of Biological Chemistry March 17 2006
  • "Splenectomy reduces infarct volume and neuroinflammation in male but not female mice in experimental stroke" Journal of Neuroimmunology January 15 2015
  • "Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function (Molecular Pharmacology (2002) 61 (1303-1312))" Molecular Pharmacology December 2013
  • "RGS4 inhibits signaling by group I metabotropic glutamate receptors" Journal of Neuroscience  1998
  • "Developmental expression of the Drosophila melanogaster calmodulin gene" International Journal of Developmental Biology  1992

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