Photo of Jon D. Hennebold, Ph.D.

Jon D. Hennebold Ph.D.

  • (503) 346-5395
    • Professor Oregon National Primate Research Center
    • Adjunct Professor of Obstetrics and Gynecology School of Medicine
    • Adjunct Professor of Physiology and Pharmacology School of Medicine
    • Chief, Division of Reproductive & Developmental Sciences Oregon National Primate Research Center
    • Co-Director, Assisted Reproductive Technologies (ART) Support Core Oregon National Primate Research Center
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. Jon D. Hennebold is Professor and Chief in the Division of Reproductive & Developmental Sciences. He is an adjunct faculty member in the Departments of Obstetrics & Gynecology and Physiology & Pharmacology in the School of Medicine. Dr. Hennebold also currently serves as Co-Director of the ONPRC Assisted Reproductive Technologies (ART) Core, which supports research activities involving nonhuman primate studies of reproductive biology and the development of models for human diseases through the use of recently created gene editing techniques.

Dr. Hennebold’s team studies the events necessary for the function of the primate ovary to better understand the causes of female infertility and to aid in the development of novel contraceptives. His group is specifically interested in the molecular and cellular pathways that are critical for ovulation and the release of an oocyte capable of undergoing fertilization. His laboratory is also active in determining how the ruptured ovulatory follicle becomes the corpus luteum, which is responsible for producing the steroid hormone progesterone that prepares the uterus for implantation if fertilization occurs and sustaining pregnancy during the first trimester.

He received his Ph.D. in immunology and cell biology at the Department of Pathology, University of Utah School of Medicine in 1996. Dr. Hennebold then conducted his postdoctoral training in reproductive sciences at the University of Utah Department of Obstetrics & Gynecology. In 2000, he joined ONPRC as a Staff Scientist and was promoted to Assistant Scientist in 2003. Dr. Hennebold has served as division Chief since 2014.

 

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Areas of interest

  • Reproductive physiology
  • Infertility
  • Contraception
  • Fertilization and early embryonic development
  • Assisted reproductive technologies
  • Gene editing and disease models

Education

  • B.S., Utah State University 1988
  • Ph.D., University of Utah 1996
  • Fellowship:

    • Postdoctoral Fellowship, Reproductive Biology, University of Utah, 2000

Honors and awards

  • Recipient of a Lalor Postdoctoral Fellowship

Memberships and associations

  • The Endocrine Society
  • The Society for the Study of Reproduction
  • The American Society for Reproductive Medicine
  • Fellow, Society of Family Planning
  • Elected Member, Board of Directors, The Society for the Study of Reproduction
  • Associate Editor, BMC Genomics, 2010-2016
  • Board of Reviewing Editors for The Biology of Reproduction, 2011-2017
  • Section Editor, Reproductive Biology & Endocrinology, 2016-present
  • Standing Member, Integrative and Clinical Endocrinology and Reproduction (ICER) Study Section, National Institute of Health, 2017-present

Publications

  • "Effect of a combined estrogen and progesterone oral contraceptive on circulating adipocytokines adiponectin, resistin and DLK-1 in normal and obese female rhesus monkeys" Contraception July 2013
  • "Phosphodiesterase 3 (PDE3) inhibition with cilostazol does not block in vivo oocyte maturation in rhesus macaques (Macaca mulatta)" Contraception May 1 2015
  • "Discovery of a novel imprinted gene by transcriptional analysis of parthenogenetic embryonic stem cells" Human Reproduction August 2010
  • "Regulation of macrophage dehydroepiandrosterone sulfate metabolism by inflammatory cytokines" Endocrinology July 1994
  • "Impact of the prostaglandin synthase-2 inhibitor celecoxib on ovulation and luteal events in women" Contraception March 2013
  • "Systematic determination of differential gene expression in the primate corpus luteum during the luteal phase of the menstrual cycle" Molecular Endocrinology May 2008
  • "A nonhormonal model for emergency contraception" Contraception June 2010
  • "Discovery of LH-regulated genes in the primate corpus luteum" Molecular Human Reproduction March 2005
  • "Endocrine and local control of the primate corpus luteum" Reproductive biology December 2013
  • "Dynamic changes in gene expression that occur during the period of spontaneous functional regression in the rhesus macaque corpus luteum" Endocrinology March 2009
  • "Novel cleft susceptibility genes in chromosome 6q" Journal of Dental Research September 2010
  • "Systematic analysis of protease gene expression in the rhesus macaque ovulatory follicle" Endocrinology October 2011
  • "DHEA and immune function" Seminars in Reproductive Medicine  1995
  • "Liver X receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells" Biology of Reproduction March 1 2012
  • "A prostaglandin E2 receptor antagonist prevents pregnancies during a preclinical contraceptive trial with female macaques" Human Reproduction  2014
  • "Does DHEAS restore immune competence in aged animals through its capacity to function as a natural modulator of peroxisome activities?" Annals of the New York Academy of Sciences  1995
  • "Inhibition of skin 11β-hydroxysteroid dehydrogenase activity in vivo potentiates the anti-inflammatory actions of glucocorticoids" Archives of Dermatological Research  1998
  • "Mechanisms of disease" New England Journal of Medicine March 4 1999
  • "The generation and characterization of an ovary-selective cDNA library" Molecular and Cellular Endocrinology April 28 2003
  • "Dynamics of the transcriptome in the primate ovulatory follicle" Molecular Human Reproduction March 2011
  • "Epigenetic reprogramming by somatic cell nuclear transfer in primates" Stem Cells June 2009
  • "Dynamic expression and regulation of the corticotropin-releasing hormone/urocortin-receptor-binding protein system in the primate ovary during the menstrual cycle" Journal of Clinical Endocrinology and Metabolism April 2006
  • "Cumulus-oocyte complexes from small antral follicles during the early follicular phase of menstrual cycles in rhesus monkeys yield oocytes that reinitiate meiosis and fertilize in vitro" Biology of Reproduction October 2010
  • "The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies" Biology of Reproduction December 2006
  • "Ovary-selective genes I" Endocrinology  2000
  • "Active catabolism of glucocorticoids by 11β-hydroxysteroid dehydrogenase in vivo is a necessary requirement for natural resistance to infection with Listeria monocytogenes" International Immunology  1997
  • "The effects of luteinizing hormone ablation/replacement versus steroid ablation/replacement on gene expression in the primate corpus luteum" Molecular Human Reproduction  2009
  • "Oct-4 Expression in Pluripotent Cells of the Rhesus Monkey" Biology of Reproduction December 2003
  • "A mammalian oocyte-specific linker histone gene H1oo" Development (Cambridge)  2001
  • "Preventing granulosa cell apoptosis through the action of a single microRNA" Biology of Reproduction  2010

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