Jon D. Hennebold, Ph.D.

  • Professor, Oregon National Primate Research Center
  • Adjunct Professor of Obstetrics and Gynecology, School of Medicine
  • Chief, Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center
  • Member, Program in Molecular and Cellular Biosciences
  • Center for Developmental Health, School of Medicine


Dr. Jon D. Hennebold is Professor and Chief in the Division of Reproductive and Developmental Sciences. He is an adjunct faculty member in the Department of Obstetrics and Gynecology.

Dr. Hennebold’s team studies the events necessary for the function of the primate ovary to understand the causes of female infertility and to aid in the development of novel contraceptives. His group is specifically interested in the molecular and cellular pathways that are critical for ovulation and the release of an oocyte capable of undergoing fertilization. His laboratory is also active in determining how the ruptured ovulatory follicle becomes the corpus luteum, which is responsible for producing the steroid hormone progesterone that prepares the uterus for implantation if fertilization occurs and sustaining pregnancy during the first trimester. Studies are underway in his laboratory that seek to define how environmental factors, such as an obesogenic Western-style diet, alone or in combination with abnormal endocrine and metabolic processes negatively affect ovarian function and fertility. His research in this area has revealed that the chronic consumption of a Western-style diet alone or in the presence of elevated circulating levels of testosterone, comparable to what is seen in women within polycystic ovary syndrome, alters ovarian function and reduces the ability of resident oocytes to develop properly after fertilization. Through his interest in assisted reproductive technologies and recently developed gene editing techniques, Dr. Hennebold’s laboratory also has several projects funded through foundations and the NIH to develop models of disease and to improve somatic cell gene editing approaches for their treatment. Dr. Hennebold is part of a team funded through the NIH Somatic Cell Genome Editing Resource that is working toward generating a reporter system that can be used to test newly developed somatic cell gene editing reagents and delivery systems.  

He received his Ph.D. in immunology and cell biology at the Department of Pathology, University of Utah School of Medicine in 1996. Dr. Hennebold then conducted his postdoctoral training in reproductive sciences at the University of Utah Department of Obstetrics and Gynecology. In 2000, he joined ONPRC as a Staff Scientist and was promoted to Assistant Scientist in 2003. Dr. Hennebold has served as the Division Chief for Reproductive and Developmental Sciences since 2014.

Education and training

    • B.S., 1988, Utah State University
    • Ph.D., 1996, University of Utah
  • Fellowship

    • Postdoctoral Fellowship, Reproductive Biology, University of Utah, 2000

Memberships and associations:

  • The Society for the Study of Reproduction
  • The Endocrine Society
  • The American Society for Reproductive Medicine
  • Fellow, Society of Family Planning
  • Associate Editor, BMC Genomics, 2010-2016
  • Board of Reviewing Editors for The Biology of Reproduction, 2011-2017
  • Section Editor, Reproductive Biology & Endocrinology, 2016-2018
  • Chair, Integrative and Clinical Endocrinology and Reproduction (ICER) Study Section, National Institute of Health, 2017-present

Areas of interest

  • Reproductive physiology
  • Infertility
  • Contraception
  • Fertilization and early embryonic development
  • Assisted reproductive technologies
  • Gene editing and disease models
  • Precision medicine

Honors and awards

  • Recipient of a Lalor Postdoctoral Fellowship


Selected publications

  • Ravisankar S, Ting AY, Murphy MJ, Redmayne N, Wang D, McArthur CA, Takahashi DL, Kievit P, Chavez SL, Hennebold JD. Short-term Western-style diet negatively impacts reproductive outcomes in primates. JCI Insight. 2021 Feb 22;6(4):138312. doi: 10.1172/jci.insight.138312. PMID: 33616080.
  • Bishop CV, Takahashi D, Mishler E, Slayden OD, Roberts CT, Hennebold J, True C. Individual and combined effects of 5-year exposure to hyperandrogenemia and Western-style diet on metabolism and reproduction in female rhesus macaques. Hum Reprod. 2021 Jan 25;36(2):444-454. doi: 10.1093/humrep/deaa321. PMID: 33313720; PMCID: PMC7829549.
  • Howland D, Ellederova Z, Aronin N, Fernau D, Gallagher J, Taylor A, Hennebold J, Weiss AR, Gray-Edwards H, McBride J. Large Animal Models of Huntington's Disease: What We Have Learned and Where We Need to Go Next. J Huntingtons Dis. 2020;9(3):201-216. doi: 10.3233/JHD-200425. PMID: 32925082; PMCID: PMC7597371.
  • Bishop CV, Reiter TE, Erikson DW, Hanna CB, Daughtry BL, Chavez SL, Hennebold JD, Stouffer RL. Chronically elevated androgen and/or consumption of a Western-style diet impairs oocyte quality and granulosa cell function in the nonhuman primate periovulatory follicle. J Assist Reprod Genet. 2019 Jul;36(7):1497-1511. doi: 10.1007/s10815-019-01497-8. Epub 2019 Jun 11. PMID: 31187329; PMCID: PMC6657409.
  • Fayomi AP, Peters K, Sukhwani M, Valli-Pulaski H, Shetty G, Meistrich ML, Houser L, Robertson N, Roberts V, Ramsey C, Hanna C, Hennebold JD, Dobrinski I, Orwig KE. Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring. Science. 2019 Mar 22;363(6433):1314-1319. doi: 10.1126/science.aav2914. Erratum in: Science. 2019 Apr 5;364(6435):. PMID: 30898927; PMCID: PMC6598202.
  • Edelman AB, Jensen JT, McCrimmon S, Messerle-Forbes M, O'Donnell A, Hennebold JD. Combined oral contraceptive interference with the ability of ulipristal acetate to delay ovulation: A prospective cohort study. Contraception. 2018 Dec;98(6):463-466. doi: 10.1016/j.contraception.2018.08.003. Epub 2018 Aug 14. PMID: 30118684; PMCID: PMC6204102.
  • Xu J, Lawson MS, Xu F, Du Y, Tkachenko OY, Bishop CV, Pejovic-Nezhat L, Seifer DB, Hennebold JD. Vitamin D3 Regulates Follicular Development and Intrafollicular Vitamin D Biosynthesis and Signaling in the Primate Ovary. Front Physiol. 2018 Nov 14;9:1600. doi: 10.3389/fphys.2018.01600. PMID: 30487754; PMCID: PMC6246691.
  • Robker RL, Hennebold JD, Russell DL. Coordination of Ovulation and Oocyte Maturation: A Good Egg at the Right Time. Endocrinology. 2018 Sep 1;159(9):3209-3218. doi: 10.1210/en.2018-00485. PMID: 30010832; PMCID: PMC6456964.
  • Murphy MJ, Halow NG, Royer PA, Hennebold JD. Leukemia Inhibitory Factor Is Necessary for Ovulation in Female Rhesus Macaques. Endocrinology. 2016 Nov;157(11):4378-4387. doi: 10.1210/en.2016-1283. Epub 2016 Aug 29. PMID: 27571132; PMCID: PMC5086537.
  • Bishop CV, Hennebold JD, Kahl CA, Stouffer RL. Knockdown of Progesterone Receptor (PGR) in Macaque Granulosa Cells Disrupts Ovulation and Progesterone Production. Biol Reprod. 2016 May;94(5):109. doi: 10.1095/biolreprod.115.134981. Epub 2016 Mar 16. PMID: 26985003; PMCID: PMC4939739.


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