Jon D. Hennebold, Ph.D.

  • Professor, Oregon National Primate Research Center
  • Adjunct Professor of Obstetrics and Gynecology, School of Medicine
  • Adjunct Professor of Physiology and Pharmacology, School of Medicine
  • Chief, Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center
  • Program in Molecular and Cellular Biosciences, School of Medicine


Dr. Jon D. Hennebold is Professor and Chief in the Division of Reproductive and Developmental Sciences. He is an adjunct faculty member in the Departments of Obstetrics and Gynecology and Physiology and Pharmacology in the School of Medicine.

Dr. Hennebold’s team studies the events necessary for the function of the primate ovary to understand the causes of female infertility and to aid in the development of novel contraceptives. His group is specifically interested in the molecular and cellular pathways that are critical for ovulation and the release of an oocyte capable of undergoing fertilization. His laboratory is also active in determining how the ruptured ovulatory follicle becomes the corpus luteum, which is responsible for producing the steroid hormone progesterone that prepares the uterus for implantation if fertilization occurs and sustaining pregnancy during the first trimester. Studies are underway in his laboratory that seek to define how environmental factors, such as an obesogenic Western-style diet, alone or in combination with abnormal endocrine and metabolic processes negatively affect ovarian function and fertility. His research in this area has revealed that the chronic consumption of a Western-style diet in the presence of elevated circulating levels of testosterone, comparable to what is seen in women within polycystic ovary syndrome, alters ovarian function and reduces the ability of resident oocytes to develop properly after fertilization. Through his interest in assisted reproductive technologies and recently developed gene editing techniques, Dr. Hennebold’s laboratory also has several projects funded through foundations and the NIH to develop models of disease and to improve somatic cell gene editing approaches for their treatment. Dr. Hennebold is part of a team funded through the NIH Somatic Cell Genome Editing Resource that is working toward generating a reporter system that can be used to test newly developed somatic cell gene editing reagents and delivery systems.  

He received his Ph.D. in immunology and cell biology at the Department of Pathology, University of Utah School of Medicine in 1996. Dr. Hennebold then conducted his postdoctoral training in reproductive sciences at the University of Utah Department of Obstetrics and Gynecology. In 2000, he joined ONPRC as a Staff Scientist and was promoted to Assistant Scientist in 2003. Dr. Hennebold has served as the Division Chief for Reproductive and Developmental Sciences since 2014.


  • B.S., 1988, Utah State University
  • Ph.D., 1996, University of Utah
  • Fellowship:

    • Postdoctoral Fellowship, Reproductive Biology, University of Utah, 2000

Honors and awards

  • Recipient of a Lalor Postdoctoral Fellowship

Memberships and associations

  • The Society for the Study of Reproduction
  • The Endocrine Society
  • The American Society for Reproductive Medicine
  • Fellow, Society of Family Planning
  • Elected Member, Board of Directors, The Society for the Study of Reproduction
  • Associate Editor, BMC Genomics, 2010-2016
  • Board of Reviewing Editors for The Biology of Reproduction, 2011-2017
  • Section Editor, Reproductive Biology & Endocrinology, 2016-2018
  • Chair, Integrative and Clinical Endocrinology and Reproduction (ICER) Study Section, National Institute of Health, 2017-present

Areas of interest

  • Reproductive physiology
  • Infertility
  • Contraception
  • Fertilization and early embryonic development
  • Assisted reproductive technologies
  • Gene editing and disease models


Selected publications

  • Bishop CV, Reiter TE, Erikson DW, Hanna CB, Daughtry BL, Chavez SL, Hennebold JD, Stouffer RL. Chronically elevated androgen and/or consumption of a Western-style diet impairs oocyte quality and granulosa cell function in the nonhuman primate periovulatory follicle. J Assist Reprod Genet. 2019 Jul;36(7):1497-1511. doi: 10.1007/s10815-019-01497-8. Epub 2019 Jun 11. PMID: 31187329; PMCID: PMC6657409.
  • Fayomi AP, Peters K, Sukhwani M, Valli-Pulaski H, Shetty G, Meistrich ML, Houser L, Robertson N, Roberts V, Ramsey C, Hanna C, Hennebold JD, Dobrinski I, Orwig KE. Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring. Science. 2019 Mar 22;363(6433):1314-1319. doi: 10.1126/science.aav2914. Erratum in: Science. 2019 Apr 5;364(6435):. PMID: 30898927; PMCID: PMC6598202.
  • Edelman AB, Jensen JT, McCrimmon S, Messerle-Forbes M, O'Donnell A, Hennebold JD. Combined oral contraceptive interference with the ability of ulipristal acetate to delay ovulation: A prospective cohort study. Contraception. 2018 Dec;98(6):463-466. doi: 10.1016/j.contraception.2018.08.003. Epub 2018 Aug 14. PMID: 30118684; PMCID: PMC6204102.
  • Bishop CV, Xu F, Steinbach R, Ficco E, Hyzer J, Blue S, Stouffer RL, Hennebold JD. Changes in immune cell distribution and their cytokine/chemokine production during regression of the rhesus macaque corpus luteum. Biol Reprod. 2017 Jun 1;96(6):1210-1220. doi: 10.1093/biolre/iox052. PMID: 28575196; PMCID: PMC6279079.
  • Murphy MJ, Halow NG, Royer PA, Hennebold JD. Leukemia Inhibitory Factor Is Necessary for Ovulation in Female Rhesus Macaques. Endocrinology. 2016 Nov;157(11):4378-4387. doi: 10.1210/en.2016-1283. Epub 2016 Aug 29. PMID: 27571132; PMCID: PMC5086537.
  • Bishop CV, Hennebold JD, Kahl CA, Stouffer RL. Knockdown of Progesterone Receptor (PGR) in Macaque Granulosa Cells Disrupts Ovulation and Progesterone Production. Biol Reprod. 2016 May;94(5):109. doi: 10.1095/biolreprod.115.134981. Epub 2016 Mar 16. PMID: 26985003; PMCID: PMC4939739.
  • Bishop CV, Xu F, Xu J, Ting AY, Galbreath E, McGee WK, Zelinski MB, Hennebold JD, Cameron JL, Stouffer RL. Western-style diet, with and without chronic androgen treatment, alters the number, structure, and function of small antral follicles in ovaries of young adult monkeys. Fertil Steril. 2016 Apr;105(4):1023-34. doi: 10.1016/j.fertnstert.2015.11.045. Epub 2015 Dec 21. PMID: 26718060; PMCID: PMC4821692.
  • Peluffo MC, Stanley J, Braeuer N, Rotgeri A, Fritzemeier KH, Fuhrmann U, Buchmann B, Adevai T, Murphy MJ, Zelinski MB, Lindenthal B, Hennebold JD, Stouffer RL. A prostaglandin E2 receptor antagonist prevents pregnancies during a preclinical contraceptive trial with female macaques. Hum Reprod. 2014 Jul;29(7):1400-12. doi: 10.1093/humrep/deu083. Epub 2014 Apr 29. PMID: 24781425; PMCID: PMC4059334.
  • Peluffo MC, Ting AY, Zamah AM, Conti M, Stouffer RL, Zelinski MB, Hennebold JD. Amphiregulin promotes the maturation of oocytes isolated from the small antral follicles of the rhesus macaque. Hum Reprod. 2012 Aug;27(8):2430-7. doi: 10.1093/humrep/des158. Epub 2012 May 16. PMID: 22593432; PMCID: PMC3398676.
  • Xu F, Stouffer RL, Müller J, Hennebold JD, Wright JW, Bahar A, Leder G, Peters M, Thorne M, Sims M, Wintermantel T, Lindenthal B. Dynamics of the transcriptome in the primate ovulatory follicle. Mol Hum Reprod. 2011 Mar;17(3):152-65. doi: 10.1093/molehr/gaq089. Epub 2010 Oct 29. PMID: 21036944; PMCID: PMC3037735.


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