Headshot photo of Jon D. Hennebold, Ph.D.

Jon D. Hennebold, Ph.D.

  • Associate Director of Research, Oregon National Primate Research Center
  • Professor , Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center
  • Adjunct Professor, Obstetrics and Gynecology, School of Medicine
  • Member, Program in Molecular and Cellular Biosciences, Center for Developmental Health, School of Medicine


Dr. Jon D. Hennebold is the Associate Director of Research for the Oregon National Primate Center and Professor in the Division of Reproductive & Developmental Sciences. He is an adjunct faculty member in the Department of Obstetrics and Gynecology.

Dr. Hennebold’s team studies the events necessary for the function of the primate ovary to understand the causes of female infertility and to aid in developing novel contraceptives. His group is specifically interested in the molecular and cellular pathways that are critical for ovulation and the release of an oocyte capable of undergoing fertilization. His laboratory is also active in determining how the ruptured ovulatory follicle becomes the corpus luteum, which produces the steroid hormone progesterone that prepares the uterus for implantation if fertilization occurs and sustains pregnancy during the first trimester. Studies are underway in his laboratory that seeks to define how environmental factors, such as an obesogenic Western-style diet, alone or in combination with abnormal endocrine and metabolic processes, negatively affect ovarian function and fertility. His research in this area has revealed that the chronic consumption of a Western-style diet alone or in the presence of elevated circulating levels of testosterone, comparable to what is seen in women with polycystic ovary syndrome, alters ovarian function and reduces the ability of resident oocytes to develop properly after fertilization. Through his interest in assisted reproductive technologies and recently developed gene editing techniques, Dr. Hennebold’s laboratory also has several projects funded through foundations and the NIH to develop models of disease and to improve somatic cell gene editing approaches for their treatment.

He received his Ph.D. in the Division of Immunology & Cell Biology at the Department of Pathology, University of Utah School of Medicine in 1996. Dr. Hennebold then conducted his postdoctoral training in reproductive sciences at the University of Utah Department of Obstetrics and Gynecology. In 2000, he joined ONPRC as a Staff Scientist and was promoted to Assistant Scientist in 2002. Dr. Hennebold has served as the Division Chief for Reproductive and Developmental Sciences from 2014 through 2022. Since November 2022, Dr. Hennebold has been serving as the Interim Director of the Center.

Education and training

    • B.S., 1988, Utah State University
    • Ph.D., 1996, University of Utah
  • Fellowship

    • Postdoctoral Fellowship, Reproductive Biology, University of Utah, 2000

Memberships and associations:

  • The Society for the Study of Reproduction
  • The Endocrine Society
  • The American Society for Reproductive Medicine
  • Associate Editor, BMC Genomics, 2010-2016
  • Board of Reviewing Editors for The Biology of Reproduction, 2011-2017
  • Section Editor, Reproductive Biology & Endocrinology, 2016-2018
  • Chair, Integrative and Clinical Endocrinology and Reproduction (ICER) Study Section, National Institute of Health, 2017-present

Areas of interest

  • Reproductive physiology
  • Infertility
  • Contraception
  • Fertilization and early embryonic development
  • Assisted reproductive technologies
  • Gene editing and disease models
  • Precision medicine

Honors and awards

  • Recipient of a Lalor Postdoctoral Fellowship


Selected publications

  • Yerushalmi GM, Shuraki B, Yung Y, Maman E, Baum M, Hennebold JD, Adashi EY, Hourvitz A. ABCC4 is a PGE2 efflux transporter in the ovarian follicle: A mediator of ovulation and a potential non-hormonal contraceptive target. FASEB J. 2023 Apr;37(4):e22858.  PMID: 36943419.
  • Ryu J, Adashi EY, Hennebold JD. The History, Use, and Challenges of Therapeutic Somatic Cell and Germline Gene Editing. Fertil Steril. 2023  Epub ahead of print. PMID: 36878350.
  • Sureshchandra S, Chan CN, Robino JJ, Parmelee LK, Nash MJ, Wesolowski SR, Pietras EM, Friedman JE, Takahashi D, Shen W, Jiang X, Hennebold JD, Goldman D, Packwood W, Lindner JR, Roberts CT Jr, Burwitz BJ, Messaoudi I, Varlamov O. Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques. Stem Cell Reports. 2022 Dec 13;17(12):2595-2609. PMID: 36332628; PMCID: PMC9768582.
  • Bishop CV, Takahashi DL, Luo F, Sidener H, Martin LD, Gao L, Fei SS, Hennebold JD, Slayden OD. The combined impact of testosterone and Western-style diet on endometriosis severity and progression in rhesus macaques. Biol Reprod. 2023 Jan 14;108(1):72-80. PMID: 36173894; PMCID: PMC9843674.
  • Edelman AB, Hennebold JD, Bond K, Lim JY, Cherala G, Archer DF, Jensen JT. Double Dosing Levonorgestrel-Based Emergency Contraception for Individuals With Obesity: A Randomized Controlled Trial. Obstet Gynecol. 2022 Jul 1;140(1):48-54. PMID: 35849455; PMCID: PMC9205298.
  • Edelman AB, Jensen JT, McCrimmon S, Messerle-Forbes M, O'Donnell A, Hennebold JD. Combined oral contraceptive interference with the ability of ulipristal acetate to delay ovulation: A prospective cohort study. Contraception. 2018 Dec;98(6):463-466. doi: 10.1016/j.contraception.2018.08.003. Epub 2018 Aug 14. PMID: 30118684; PMCID: PMC6204102.
  • Ryu J, Statz JP, Chan W, Burch FC, Brigande JV, Kempton B, Porsov EV, Renner L, McGill T, Burwitz BJ, Hanna CB, Neuringer M, Hennebold JD. CRISPR/Cas9 editing of the MYO7A gene in rhesus macaque embryos to generate a primate model of Usher syndrome type 1B. Sci Rep. 2022 Jun 16;12(1):10036. PMID: 35710827; PMCID: PMC9203743.
  • Ryu J, Chan W, Wettengel JM, Hanna CB, Burwitz BJ, Hennebold JD, Bimber BN. Rapid, accurate mapping of transgene integration in viable rhesus macaque embryos using enhanced-specificity tagmentation-assisted PCR. Mol Ther Methods Clin Dev. 2022 Jan 19;24:241-254. PMID: 35211637; PMCID: PMC8829455.
  • Ravisankar S, Murphy MJ, Redmayne-Titley N, Davis B, Luo F, Takahashi D, Hennebold JD, Chavez SL. Long-term Hyperandrogenemia and/or Western-style Diet in Rhesus Macaque Females Impairs Preimplantation Embryogenesis. Endocrinology. 2022 Apr 1;163(4):bqac019.  PMID: 35192701; PMCID: PMC8962721.
  • Ravisankar S, Ting AY, Murphy MJ, Redmayne N, Wang D, McArthur CA, Takahashi DL, Kievit P, Chavez SL, Hennebold JD. Short-term Western-style diet negatively impacts reproductive outcomes in primates. JCI Insight. 2021 Feb 22;6(4):138312. PMID: 33616080.
  • Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, et al.; SCGE Consortium. The NIH Somatic Cell Genome Editing program. Nature. 2021 Apr;592(7853):195-204. PMID: 33828315; PMCID: PMC802639
  • Bishop CV, Takahashi D, Mishler E, Slayden OD, Roberts CT, Hennebold J, True C. Individual and combined effects of 5-year exposure to hyperandrogenemia and Western-style diet on metabolism and reproduction in female rhesus macaques. Hum Reprod. 2021 Jan 25;36(2):444-454. PMID: 33313720; PMCID: PMC7829549.
  • Howland D, Ellederova Z, Aronin N, Fernau D, Gallagher J, Taylor A, Hennebold J, Weiss AR, Gray-Edwards H, McBride J. Large Animal Models of Huntington's Disease: What We Have Learned and Where We Need to Go Next. J Huntingtons Dis. 2020;9(3):201-216. PMID: 32925082; PMCID: PMC7597371.
  • Bishop CV, Reiter TE, Erikson DW, Hanna CB, Daughtry BL, Chavez SL, Hennebold JD, Stouffer RL. Chronically elevated androgen and/or consumption of a Western-style diet impairs oocyte quality and granulosa cell function in the nonhuman primate periovulatory follicle. J Assist Reprod Genet. 2019 Jul;36(7):1497-1511. PMID: 31187329; PMCID: PMC6657409.
  • Fayomi AP, Peters K, Sukhwani M, Valli-Pulaski H, Shetty G, Meistrich ML, Houser L, Robertson N, Roberts V, Ramsey C, Hanna C, Hennebold JD, Dobrinski I, Orwig KE. Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring. Science. 2019 Mar 22;363(6433):1314-1319. PMID: 30898927; PMCID: PMC6598202.
  • Edelman AB, Jensen JT, McCrimmon S, Messerle-Forbes M, O'Donnell A, Hennebold JD. Combined oral contraceptive interference with the ability of ulipristal acetate to delay ovulation: A prospective cohort study. Contraception. 2018 Dec;98(6):463-466. PMID: 30118684; PMCID: PMC6204102.


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