Photo of Joe W. Gray, Ph.D.

Joe W. Gray Ph.D.

  • (503) 418-6500
    • Professor of Biomedical Engineering School of Medicine
    • Gordon Moore Endowed Chair Biomedical Engineering School of Medicine
    • Associate Director for Biophysical Oncology OHSU Knight Cancer Institute School of Medicine
    • Director OHSU Center for Spatial Systems Biomedicine School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine
    • Cancer Biology Graduate Program School of Medicine

Dr. Joe W. Gray, a physicist and an engineer by training, holds positions as Professor and Gordon Moore Endowed Chair, Biomedical Engineering Department; Director, Center for Spatial Systems Biomedicine (OCSSB); and Associate Director for Biophysical Oncology, Knight Cancer Institute at the Oregon Health & Science University. He is also Emeritus Professor, University of California, San Francisco; and Senior Scientist, Lawrence Berkeley National Laboratory.

He was a Staff Scientist in the Biomedical Sciences Division of the Lawrence Livermore National Laboratory (1972-1991), Professor of Laboratory Medicine at the University of California, San Francisco (1991-2011), and Associate Laboratory Director for Biosciences and Life Sciences Division Director at the Lawrence Berkeley National Laboratory (2003-2011).

He is Principal Investigator of the National Cancer Institute/Research Center for Cancer Systems Biology Consortium (CSBC), "Measuring, Modeling and Controlling Heterogeneity" (M2CH) that is aimed at developing a systems level understanding of how intrinsic and extrinsic factors work together to enable triple-negative breast cancer to escape therapeutic control in order to devise robust control strategies; PI of a National Institutes of Health program to contribute to further development of the NIH Library of Integrated Network-based Cellular Signatures program (LINCS) to develop a dataset and computational strategy to elucidate how microenvironmental signals affect cell intrinsic intracellular transcriptional- and protein-defined molecular networks to generate experimentally durable therapies for patients; co-director of the "Serial Measurement of Molecular and Architectural Responses to Therapy" (SMMART) clinical trials program that aims to provide a transformative approach to cancer treatment that focuses on each person who faces cancer to create more effective, durable therapies for treatment of prostate cancer, pancreatic cancer and leukemia; PI of a Brenden Colson Center for Pancreatic Health project that provides support for a broad-based, team approach to finding causes, early detection and improvement of clinical care for pancreatic diseases including pancreatitis and pancreatic cancer; and PI of a Susan G. Komen project to identify the mechanisms by which ERBB2+ breast cancer cells escape inhibition by ERRB2-targeted therapies.

Dr. Gray's work is described in over 500 publications and 80 US patents. He is a Fellow of the American Association for the Advancement of Science and the American Institute for Medical and Biological Engineering; an elected a member of the Institute of Medicine of the National Academy of Sciences; a member of the National Institutes of Health; a Fellow of the American Association of Cancer Research Academy; and Executive Councilor of the Board of Councilors for the Radiation Effects Research Foundation (RERF), Hiroshima, Japan.

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Education

  • Ph.D., Kansas State University, Manhattan Kansas 1972

Memberships and associations

  • American Association for Cancer Research
  • American Association for the Advancement of Science
  • American Society for Human Genetics
  • Human Genome Organization
  • International Society for Analytical Cytology
  • Radiation Research Society

Publications

  • "Chromosome classification and purification using flow cytometry and sorting." Annual Review of Biophysics  1986
  • "Objective aneuploidy detection for fetal and neonatal screening using comparative genomic hybridization (CGH)" Communications in Clinical Cytometry July 1 1997
  • "Digital imaging microscopy for molecular cytogenetics"   1994
  • "Identification of gene regulation patterns underlying both oestrogen- and tamoxifen-stimulated cell growth through global gene expression profiling in breast cancer cells" European Journal of Cancer  2014
  • "Identification of frequent novel genetic alterations in small cell lung carcinoma" Journal of Cancer Research October 1 1994
  • "End-sequence profiling" Proceedings of the National Academy of Sciences of the United States of America June 24 2003
  • "Optimization-based inference for temporally evolving networks with applications in biology" Journal of Computational Biology December 1 2012
  • "Morphometic analysis of TCGA glioblastoma multiforme" BMC Bioinformatics December 20 2011
  • "In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002)" Clinical Cancer Research March 2000
  • "Comparative genomic hybridization." Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] May 2001
  • "C-Src modulates estrogen-induced stress and apoptosis in estrogen-deprived breast cancer cells" Journal of Cancer Research July 15 2013
  • "Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature" BMC Cancer November 21 2008
  • "Integrated analysis of breast cancer cell lines reveals unique signaling pathways" Genome Biology March 25 2009
  • "Effect of methylglyoxal-bis (guanylhydrazone), an inhibitor of spermidine and spermine synthesis, on cell cycle traverse" European journal of cancer  1977
  • "Cytokinetic characterization of the response of the KHT tumor to ara-C" European Journal of Histochemistry  1980
  • "Preface" Indian Journal of Rheumatology  2008
  • "Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination" Proceedings of the National Academy of Sciences of the United States of America September 1 2015
  • "Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture" PLoS Computational Biology February 2010
  • "Measurement of sister chromatid exchanges at very low bromodeoxyuridine substitution levels using a monoclonal antibody in Chinese hamster ovary cells" Journal of Cancer Research  1985
  • "Cycle progression and division of viable and nonviable Chinese hamster ovary cells following acute hyperthermia and their relationship to thermal tolerance decay" Journal of Cancer Research  1984
  • "A primer on regression methods for decoding cis-regulatory logic" PLoS Computational Biology January 2009
  • "Genome-wide methylation analysis identifies genes specific to breast cancer hormone receptor status and risk of recurrence" Journal of Cancer Research October 1 2011
  • "Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges" Nature Structural and Molecular Biology December 2013
  • "Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization" Proceedings of the National Academy of Sciences of the United States of America  1986
  • "Rapid cell cycle analysis. II. Phase durations and dispersions from computer analysis of RC curves." Cell Proliferation September 1983
  • "Purification of the chromosomes of the Indian muntjac by flow sorting" Journal of Histochemistry and Cytochemistry  1976
  • "Segmentation of confocal microscope images of cell nuclei in thick tissue sections" Journal of Microscopy  1999
  • "High resolution chromosome analysis" Chromosoma January 1979
  • "Quantitative karyotyping of human chromosomes by dual beam flow cytometry" Proceedings of the National Academy of Sciences of the United States of America  1982
  • "Genome wide DNA copy number analysis of serous type ovarian carcinomas identifies genetic markers predictive of clinical outcome" PLoS One February 15 2012

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